Edited by Professor Marek Kimmel
Cancer is, in some sense, a condensed-time laboratory of evolution. Dedifferentiated cells form colonies that survive in a hostile environment, and they evolve new metabolic circuits and aggression and resistance mechanisms. They also can muster cooperation of fibroblasts and lymphocytes, and attract blood vessels. Modeling of these phenomena, well underway, will also help understand basic mechanisms of life.
Taken together, the articles in this thematic series illustrate the substantial progress that occurred over the past decade. Qualitative and quantitative understanding of cancer is a necessary condition for engineering approaches to fight it. The latter are still scarce.
A sequel to this series was published in 2016.