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The future of Intensive Care Medicine

New Content Item

This new Thematic Series focus on all aspects related to the future of Intensive Care Medicine, including but not limited to: organization, staffing, monitoring systems, new therapies, future organ support systems, ethical aspects.

Relevant papers can be submitted via the Springer Nature Article Processing Platform (Snapp) by selecting the article category “Thematic Series” and the T.S. title "The future of Intensive Care".

Please note: all submissions will be evaluated for relevance to the “The future of Intensive Care” theme and will also be subject to peer review.

Instructions to authors are available here

Access Thematic Series contents here

  1. There is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase) has been shown to exert reno-protective properties, although it remai...

    Authors: Niklas Bruse, Katerina Pardali, Maarten Kraan, Matthijs Kox and Peter Pickkers
    Citation: Critical Care 2024 28:50
  2. Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site of infection in ...

    Authors: Jayesh Dhanani, Jason A. Roberts, Antoine Monsel, Antoni Torres, Marin Kollef and Jean-Jacques Rouby
    Citation: Critical Care 2024 28:49
  3. Authors: Johannes Grand, Christian Hassager, Jesper Kjaergaard and Jacob E. Møller
    Citation: Critical Care 2023 27:492

    The original article was published in Critical Care 2023 27:410

    The original article was published in Critical Care 2023 27:451

  4. Sepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36 cytokines binding to the IL-36 receptor (IL-36R) in host response during sep...

    Authors: Huachen Wang, Meixiang Wang, Junlan Chen, Hongda Hou, Zheng Guo, Hong Yang, Hua Tang and Bing Chen
    Citation: Critical Care 2023 27:490
  5. There is limited evidence to guide interventions that promote cost-effectiveness in adult intensive care units (ICU). The aim of this consensus statement is to identify globally applicable interventions for be...

    Authors: Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizo Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao and Rajesh Mishra
    Citation: Critical Care 2023 27:487
  6. The effects of awake prone position on the breathing pattern of hypoxemic patients need to be better understood. We conducted a crossover trial to assess the physiological effects of awake prone position in pa...

    Authors: Domenico Luca Grieco, Luca Delle Cese, Luca S. Menga, Tommaso Rosà, Teresa Michi, Gianmarco Lombardi, Melania Cesarano, Valentina Giammatteo, Giuseppe Bello, Simone Carelli, Salvatore L. Cutuli, Claudio Sandroni, Gennaro De Pascale, Antonio Pesenti, Salvatore M. Maggiore and Massimo Antonelli
    Citation: Critical Care 2023 27:315
  7. During the COVID-19 pandemic, several centers had independently reported extending prone positioning beyond 24 h. Most of these centers reported maintaining patients in prone position until significant clinica...

    Authors: Thaïs Walter and Jean-Damien Ricard
    Citation: Critical Care 2023 27:264
  8. Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial d...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder…
    Citation: Critical Care 2023 27:260
  9. Specialized diets enriched with immune nutrients could be an important supplement in patients (pts) with acute traumatic brain injury (TBI). Omega-3 and arginine may interact with immune response and microbiot...

    Authors: A. Cotoia, R. Paradiso, G. Ferrara, G. Borriello, F. Santoro, I. Spina, L. Mirabella, K. Mariano, G. Fusco, G. Cinnella and P. Singer
    Citation: Critical Care 2023 27:244
  10. Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia—the m...

    Authors: Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vázquez, Laia Fernández-Barat…
    Citation: Critical Care 2023 27:239
  11. Multiple organ dysfunction syndrome (MODS) is an important cause of post-operative morbidity and mortality for children undergoing cardiac surgery requiring cardiopulmonary bypass (CPB). Dysregulated inflammat...

    Authors: Alexis L. Benscoter, Jeffrey A. Alten, Mihir R. Atreya, David S. Cooper, Jonathan W. Byrnes, David P. Nelson, Nicholas J. Ollberding and Hector R. Wong
    Citation: Critical Care 2023 27:193
  12. The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the microcirculation of orga...

    Authors: J. Duranteau, D. De Backer, K. Donadello, N. I. Shapiro, S. D. Hutchings, A. Rovas, M. Legrand, A. Harrois and C. Ince
    Citation: Critical Care 2023 27:190

    The Matters Arising to this article has been published in Critical Care 2023 27:352

  13. Use of extracorporeal membrane oxygenation (ECMO) in cardiopulmonary resuscitation, termed eCPR, offers the prospect of improving survival with good neurological function after cardiac arrest. After death, ECM...

    Authors: Tamar Schiff, Christian Koziatek, Erin Pomerantz, Nichole Bosson, Robert Montgomery, Brendan Parent and Stephen P. Wall
    Citation: Critical Care 2023 27:144
  14. Magnetic resonance imaging (MRI) is the preferred neuroimaging technique in pediatric patients. However, in neonates and instable pediatric patients accessibility to MRI is often not feasible due to instabilit...

    Authors: Hemmen Sabir, Florian Kipfmueller, Soyhan Bagci, Till Dresbach, Tamara Grass, Patrizia Nitsch-Felsecker, Christos Pantazis, Joachim Schmitt, Lukas Schroeder and Andreas Mueller
    Citation: Critical Care 2023 27:134
  15. Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of organ systems, medical interventions and a myriad of other factors. This together results in a complex, dynamic and d...

    Authors: Alex R. Schuurman, Peter M. A. Sloot, W. Joost Wiersinga and Tom van der Poll
    Citation: Critical Care 2023 27:102
  16. This paper discusses the use of Artificial Intelligence Chatbot in scientific writing. ChatGPT is a type of chatbot, developed by OpenAI, that uses the Generative Pre-trained Transformer (GPT) language model t...

    Authors: Michele Salvagno, Fabio Silvio Taccone and Alberto Giovanni Gerli
    Citation: Critical Care 2023 27:75

    The Correction to this article has been published in Critical Care 2023 27:99

    The Correspondence to this article has been published in Critical Care 2023 27:180

    The Comment to this article has been published in Critical Care 2023 27:148

    The Correspondence to this article has been published in Critical Care 2023 27:120

  17. Critically ill patients undergo early impairment of their gut microbiota (GM) due to routine antibiotic therapies and other environmental factors leading to intestinal dysbiosis. The GM establishes connections...

    Authors: Alberto Corriero, Raffaella Maria Gadaleta, Filomena Puntillo, Francesco Inchingolo, Antonio Moschetta and Nicola Brienza
    Citation: Critical Care 2022 26:379
  18. Since the advent of critical care in the twentieth century, the core elements that are the foundation for critical care systems, namely to care for critically ill and injured patients and to save lives, have e...

    Authors: Annette M. Esper, Yaseen M. Arabi, Maurizio Cecconi, Bin Du, Evangelos J. Giamarellos-Bourboulis, Nicole Juffermans, Flavia Machado, Sandra Peake, Jason Phua, Kathryn Rowan, Gee Young Suh and Greg S. Martin
    Citation: Critical Care 2022 26:366
  19. Molecular Adsorbent Recirculating System (MARS®) is a non-biological artificial liver device. The benefit risk ratio between uncertain clinical effects and potential adverse events remains difficult to assess....

    Authors: Clément Monet, Audrey De Jong, Yassir Aarab, Lauranne Piron, Albert Prades, Julie Carr, Fouad Belafia, Gérald Chanques, Boris Guiu, Georges-Philippe Pageaux and Samir Jaber
    Citation: Critical Care 2022 26:282
  20. To compare the safety and effects of unrestricted visiting policies (UVPs) and restricted visiting policies (RVPs) in intensive care units (ICUs) with respect to outcomes related to delirium, infection, and mo...

    Authors: Yuchen Wu, Guoqiang Wang, Zhigang Zhang, Luo Fan, Fangli Ma, Weigang Yue, Bin Li and Jinhui Tian
    Citation: Critical Care 2022 26:267
  21. Although lung protective strategy and adjunctive intervention are associated with improved survival in patients with acute respiratory distress syndrome (ARDS), the implementation of effective therapies remain...

    Authors: How-Yang Tseng, Chieh-Lung Chen, Yu-Chao Lin, Ming-Che Chuang, Wu-Huei Hsu, Wan-Yun Hsiao, Tung-Mei Chen, Min-Tzu Wang, Wei-Chun Huang, Chih-Yu Chen, Biing-Ru Wu, Chih-Yen Tu, Shinn-Jye Liang and Wei-Cheng Chen
    Citation: Critical Care 2022 26:253
  22. There is no formal diagnostic criterion for sepsis-induced cardiomyopathy (SICM), but left ventricular ejection fraction (LVEF) < 50% was the most commonly used standard. Tissue motion annular displacement (TM...

    Authors: Jieqiong Song, Yao Yao, Shilong Lin, Yizhou He, Duming Zhu and Ming Zhong
    Citation: Critical Care 2022 26:220
  23. Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of those at risk of death and persistent organ dysfunctions is necessary to e...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Christopher J. Lindsell…
    Citation: Critical Care 2022 26:210
  24. In the ideal intensive care unit (ICU) of the future, all patients are free from delirium, a syndrome of brain dysfunction frequently observed in critical illness and associated with worse ICU-related outcomes...

    Authors: Katarzyna Kotfis, Irene van Diem-Zaal, Shawniqua Williams Roberson, Marek Sietnicki, Mark van den Boogaard, Yahya Shehabi and E. Wesley Ely
    Citation: Critical Care 2022 26:200

    The Correction to this article has been published in Critical Care 2022 26:285

    The Correspondence to this article has been published in Critical Care 2022 26:334

    The Correspondence to this article has been published in Critical Care 2022 26:332