Skip to main content
Download PDF

Quality of life and its related-influencing factors in patients with cervical cancer based on the scale QLICP-CE(V2.0)

BMC Women's Health volume 24, Article number: 277 (2024) Cite this article

Abstract

Background

Quality of life research can guide clinical workers to adopt more targeted treatment and intervention measures, so as to achieve the purpose of improving patients’ quality of life. The objective of this study was to evaluate health-related quality of life in Chinese patients with cervical cancer and to explore its influencing factors.

Methods

A total of 186 patients with cervical cancer were investigated by using the QLICP-CE (V2.0) scale (Quality of Life Instruments for Cancer Patients-Cervical Cancer) developed by our group in China. The data were analyzed by t-test, one-way ANOVA, univariate analysis, and multivariate linear regression.

Results

The total score of quality of life scale for cervical cancer patients was (62.58 ± 12.69), Univariate analysis of objective clinical indexes showed that creatinine concentration was a negative influence factor in the psychological domain, potassium ion concentration was a negative influence factor in the common symptoms and side effect domain, erythrocyte content was a positive influence factor physical domain and common general domain. Multiple linear regression results suggested that clinical staging was the influencing factor of common symptom and side effect domain, common general module and total score of scale. Marital status has different degrees of influence on the psychological, social, and common general domains. The level of education also influenced scores in the social domain.

Conclusion

The total score of quality of life in patients with cervical cancer who received active treatment was acceptable. Marital status, clinical staging, and educational level are the factors that affect the quality of life of patients with cervical cancer. At the same time, potassium ion concentration, red blood cell count and creatinine concentration also have important effects on quality of life in patients with cervical cancer. Therefore, it is very important to give personalized treatment and nursing to patients based on various factors.

Peer Review reports

Introduction

Cervical cancer is a common gynecological malignant tumor, with a mortality rate of over 50% [1]. It can be a life-long disease that may seriously threaten women’s health and life [2, 3]. According to the IARC (International Agency for Research on Cancer) reports [4], cervical cancer accounted for 3.1% of all malignant tumors, with 604,127 new cases and 341,831 deaths in 2020. Among female malignant tumors worldwide, cervical cancer ranks the fourth in morbidity and mortality, accounting for 6.5% of new cases and 7.7% of deaths, respectively. Cervical cancer is more prevalent in developing countries. In 2020, there were 110,000 new cases of cervical cancer and 590,00 deaths in China. Cervical cancer ranked sixth in the incidence of female malignant tumors, accounting for 5.2% of all female malignant tumors [5].

With the change of modern disease spectrum and biomedical model, the main goal of tumor treatment has been gradually developed from prolonging survival to improving the overall health status of patients [6]. Health-related quality of life (HRQOL) has been used as an indicator to evaluate the overall health status of patients. HRQOL assessment can be applied not only to guide the selection of clinical protocols and evaluate therapeutic effects, but it may also be used to evaluate prognosis and long-term survival status. Although modern treatment methods have largely reduced pain suffered by patients with cervical cancer, there are still problems that seriously affect the quality of life of patients [7, 8]. Before these problems can be addressed, a proper scale for assessing HRQOL is needed. A large number of cervical cancer specific scales have been developed and applied in clinical practice, for example, FACT-CX 24 [9] (Functional Assessment of Cancer Therapy-Cervix) scale in the United States, and EORTC QLQ-CX24 [10] (European Organization for Research and Treatment of Cancer Quality-of-life Matrimony-Cervical Cancer Module).

Considering culture dependence of QOL, the Chinese QOL instruments system called QLICP (Quality of Life Instruments for Cancer patients) was developed by module approach [11, 12]. The updated second version of the system QLICP V2.0 includes the general module QLICP-GM V2.0 and 22 cancer-specific modules such as breast cancer, bladder cancer, prostate cancer, cervical cancer, leukemia and lymphoma, etc. The QLICP-CE (V2.0) (Quality of Life Instruments for Cancer Patients-Cervical Cancer) scale [13, 14] is a specific scale for patients with cervical cancer among this system. And in this paper, the QLICP-CE (V2.0) scale was used to investigate and evaluate the quality of life of patients with cervical cancer and explore its influencing factors. It is a new attempt to use Chinese native scale to measure HRQOL of Chinese patients with cervical cancer, which provides a reference for further research on health status of cervical cancer patients.

Methods design

This was a multi-center cross-sectional study on patients with cervical cancer admitted to the Affiliated Hospital of the Guangdong Medical University and the Yunnan Cancer Hospital from April 2016 to mid-June 2017.

Subjects

186 subjects were included in our study, patients responding to the following criteria were included in our study: (1) Patients adults (≥ 18 years), (2) Patients were diagnosed of cervical cancer, (3) Patients attained primary school education or above to ensure they could self-complete the questionnaire. The exclusion criteria were as follows: (1) Those who had cognitive dysfunction or other mental diseases were excluded, (2) The patients were illiterate and unwilling to participate in the study. Based on previous studies [14], the sample size of this study was about 10–20 times the number of items in the cervical cancer specific scale of the questionnaire, the estimated sample size for this study was 120–240.

An investigator, who was a medical doctor, explained the purpose, content and form-filling requirements of the study to the patient. Consent was sought before a patient would self-complete the study questionnaire.

Survey instruments

We administered the QLICP-CE V2.0 [14, 15], which comprised a cancer generic module QLICP-GM (V2.0) and a cervical cancer specific module. It covers 5 domains including the physical domain (PHD), psychological domain (PSD), social domain (SOD), Common symptoms and side effect domain (SSD), and specific domain (SPD). There were 44 items, each responded on a 5-point Likert scale from 1 to 5 points. The positively expressed items were assigned a score between 1 and 5, whilst the negatively stated items need to be reversed to calculate the score. Each domain score was derived by aggregating the item scores inside the domain. The total score on the scale was the sum of the domain scores. In order to facilitate comparison, the Raw Score (RS) of each dimension/total score was converted into Standard Score (SS) by using the range method, which was formulated as SS= (RS-Min)×100/R, where Min is the minimum score of this dimension/total score, and the higher the score, the better the quality of life. The QLICP-CE was developed based on the Chinese cultural background, and has been demonstrated with good reliability and validity for assessing the QOL in patients with cervical cancer in China [13, 14] .

Moreover, we also collected data on age, ethnicity, occupation, marital status, educational level, family economic status, treatment methods, clinical staging and clinical classification.

Statistical analysis

The IBM SPSS 26.0 was used to establish the database and analyzed the data. Descriptive statistics were used to summarize the socio-demographic and clinical indicators, scores in various domains of the QLICP-CE.

Age, ethnicity and marital status were converted into 2 categorical variables and assigned values of 1 and 2 respectively. Educational level and clinical staging were converted into 3 classification variables and assigned values of 1, 2 and 3 respectively (see Table 1 for specific assignment). The 9 demographic sociological indicators and 49 clinical objective indicators collected were simply correlated with scores of the 6 domains and total score of the scale. We analyzed the association of domain scores with socio-demographic and clinical variables, by t-tests and one-way ANOVA. And then LSD-T test was used for pair comparative analysis.

Table 1 Classification variable assignment table
Full size table

Multiple stepwise linear regression analyses (backward selection method) were performed to screen the influencing factors with the total score and the score of each domain being as the dependent variables respectively with entry standard ɑin ≤ 0.05, exclusion standard ɑout ≥ 0.10, and test level ɑ=0.05. And marital status, educational level and clinical staging, creatinine concentration, potassium content and red blood cell count, which were statistically significant factors in univariate analysis, were used as independent variables in multiple stepwise linear regression. The categorical independent variables were recoded (assignment) before stepwise linear regression analysis (see Table 1 in detail).

In regard to regression diagnosis on mode assumptions, VIF was used in this study for checking the presence of multi-collinearity among variables in multiple linear regression with the results indicating no multi-collinearity because of all VIF<5. There was no heteroscedasticity with Levene Statistic = 1.760, P > 0.05. The DW (Durbin- Watson) statistic was used to test the autocorrelation of the errors with the results showing no autocorrelation (DW = 1.090).

Results

Sample characteristics

A total of 186 cervical cancer patients consented to participate in the study. Their average age was 44.6 years (SD = 8.62, range = 24 to 64). Table 2 summarizes the demographics. There were 121 (65.1%) patients only received surgical treatment, 113 (60.8%) were farmers, and 155 (83.3%) were ethnic Han, 150 (80.6%) were married patients, 135 (72.6%) were squamous cell carcinoma, 79 (42.5%) patients and 88 (47.3%) patients were in clinical staging I and II, respectively, 127 (68.28%) patients had junior high school education level or below. Table 3 summarizes scores of the QLICP-CE.

Table 2 Socio-demographic and clinical characteristics of the Sample (n = 186)
Full size table
Table 3 Summary of domains of the QLICP-CE V2.0 among 186 patients with cervical cancer
Full size table

Univariable analysis of factors associated with quality of life

Tables 4 and 5 show results of the univariable analysis and simple correlation analysis of factors associated with QOL. With the exception of scores of PHD and SPD, the differences of scores in other dimensions and total scale were statistically significant (Pmax ≤ 0.02) in different marital status, with married people score being higher in these dimensions than single (Divorced/separated/widowed). The patients who attained high school education or above had significantly higher scores in PHD, SOD, CGD and TOT (Pmax ≤ 0.02) than those patients with primary school education. Patients with higher education had higher quality of life scores. Those with primary school education scored lower than those with junior high school education, and those with junior high school education scored lower than those with senior high school or above. There were statistically significant differences in PHD, SOD, SSD, CGD and TOT scores among different clinical staging (P < 0.05). Patients with clinical staging I had higher scores in the five domains mentioned above than patients with staging II, while patients with staging II had higher scores than patients with staging III. The lower the clinical staging, the higher the scores in each domain and the total quality of life. In addition, a significantly negative correlation was observed between creatinine concentrations and the PSD (r = -0.151), and between potassium ion concentration and SSD (r = -0.177). In contrast, a RBC count was significantly and positively correlated with PHD (r = 0.180) and CGD (r = 0.145).

Table 4 Univariable analysis of the effects of socio-demographic characteristics on the quality of life of cervical cancer patients
Full size table
Table 5 Simple correlation analysis of clinical objective indexes in patients with cervical cancer
Full size table

Multiple linear regression on influencing factors of quality of life

Table 6 shows the results of multiple linear regression on influencing factors of quality of life. It can be seen that patients with higher PHD were those who attained a higher educational level, or a higher RBC. Patients with higher PSD were those who were married, or a lower CRE. Patients with higher SOD were those who were married, or a higher educational level. Patients with higher SSD were those who were in a lower clinical staging of the disease, or a lower potassium ion concentration. Patients with higher CGD were those who were married, or a lower clinical staging of the disease. Furthermore, patients with higher TOT were those who were in a lower clinical staging of the disease.

Table 6 Multiple linear regression analysis of factors associated with quality of life in patients with cervical cancer
Full size table

Discussions

Main findings of the study

The present study evaluated the Quality of Life (QOL) in patients with cervical cancer, and the association between socio-demographic variables, clinical objective indicators and QOL in the Chinese population.

The total score of the QLICP-CE scale for cervical cancer patients was (62.58 ± 12.69). Univariate analysis of objective clinical indexes showed that creatinine concentration was a negative influence factor in the psychological domain, potassium ion concentration was a negative influence factor in the common symptoms and side effect domain, erythrocyte content was a positive influence factor physical domain and common/general domain. Multiple linear regression results displayed that clinical staging was the influencing factor of common symptom and side effect domain, common/general module and total score of scale. Marital status has different degrees of influence on the psychological, social, and common/ general domains. The level of education also influenced scores in the social domain.

Implications and comparison with Literatures

In the process of reading a large number of literatures, we learned that age, occupation, ethnicity and pathological types were regularly distributed in patients with cervical cancer, and our findings also showed this phenomenon. The age at which cervical cancer occurs varied from country to country. Early foreign data showed that the incidence of cervical cancer in women aged 25–35 years had a significant upward trend. In China, cervical cancer was mostly seen after the age of 35, and the most frequent age was between 45 and 50 [16, 17]. Among the 186 patients with cervical cancer in this survey, 81.2% (151/186) were > 35 years old, which was consistent with the situation of the age of cervical cancer in China reported previously. In terms of occupation, most of the patients were farmers, which was mainly related to their low income and limited access to health information. In terms of ethnicity, Han nationality was the most affected in this study, followed by other minority groups, which could be related to the fact that most of the local permanent residents were Han. In terms of pathological types of cervical cancer, there were also differences among different countries and nationalities, but the differences were not significant [18, 19]. Among the subjects of this survey, squamous cell carcinoma accounted for a large proportion (72.6%), which was consistent with the fact that squamous cell carcinoma was also the most common cancer in China [20, 21].

According to the scores of cervical cancer patients in various domains, the decreasing order is SPD, SSD, TOT, SOD, CGD, PSD and PHD. PHD reflects the physical function of patients. In addition to the impact of cervical cancer itself on patients, the adverse reactions left by radiotherapy and chemotherapy may have a significant impact on the patient’s body, and affect the long-term quality of life of patients, so the score of PHD is not high. PSD reflects the psychological function of patients. The average age of patients in this study is (44.62 ± 8.62) years old, whose menopausal symptoms and sexual dysfunction will lead to fatigue, anxiety and even depression [22, 23], and cervical cancer patients have lower scores in PSD compared with other cancer patients [24].

Creatinine concentration was a negative factor of mental function. Creatinine is one type of muscles that produces toxins, mainly by renal clearance. A high concentration of creatinine in the body may cause a series of electrolyte metabolism disorder or even multiple system function disorder, resulting in the manifestation of clinical symptoms that increases the patient’s mental load, and poor quality of life [25]. RBC count was a positive factor for PHD. High red blood cell count is beneficial to supply enough oxygen to the tissues and organs, the higher the red blood cell count, the stronger the blood oxygen carrying capacity, and the higher the PHD score, the better the patient’s quality of life. Increase in serum potassium level was associated with reduced scores in the SSD. Potassium ion is the main caution to maintain the physiological activities of cells [26]. When tumor occurs, abnormally increased potassium ion concentration desaturates the osmotic pressure and acid-base balance of cells in the body, leading to a series of metabolic disorders in the body [27], and in a variety of treatment side effects and poor quality of life.

In this study, marital status was dichotomized by married and single (divorced/separated/widowed). Multiple linear regression results indicated that the factor of marital status was included in the regression model with PSD, SOD and CGD as dependent variables respectively. And marriage was a protective factor of quality of life in these three domains, which was consistent with some published research results and reported in domestic and foreign literature [28,29,30,31]. Patients that are married can get more family support during the treatment process, with more satisfaction in emotional comfort and financial support. Cancer patients undergo a long treatment cycle, during which may suffer from physical and mental pain. As the disease progresses, patients who are single (divorced/separated/widowed) are more likely to suffer from psychological problems such as depression, anxiety and loneliness, which will affect the quality of life [32, 33].

After stepwise multiple linear regression, in the PHD and SOD domains, educational level was included in the regression model, affecting the social function of patients with cervical cancer, the higher the educational level, the higher the score, the better the quality of life; Studies have shown that patients with higher educational level have more active thinking in dealing with affairs, more ways to find spiritual support, more harmonious ways to communicate with friends and family, and can accept and deal with social interpersonal communication with a more open perspective and mentality [34]. All of these are conducive to cancer patients to relieve the negative psychology caused by illness and depression and lack of social role.

The results of this study suggested that CGD and TOT scores of patients in stage I were higher than those in stage II, while the scores of patients in stage II were higher than those in stage III, this result was consistent with the existing research conclusions. Zhao [35] showed that the quality of life of patients with intermediate and advanced cervical cancer, who was treated for six months, was still lower than that of patients with early cervical cancer. Further multivariate analysis showed that clinical staging of cervical cancer was a factor influencing the total score of multiple domains and scales. It has an important influence on the quality of life of patients with cervical cancer, and the patients with late cervical cancer stage have a poor quality of life. However, some studies suggest that stage has little influence on quality of life in patients with cervical cancer [36]. Cervical cancer patients are clinically characterized by irregular vaginal bleeding and abnormal leucorrhea. Untreated, these symptoms can worsen as the cancer progresses to an advanced stage. Advanced patients are often accompanied by metastasis and cachexia, and the patient’s physique will be significantly reduced compared to the early stage. All these will bring unpleasant physical and mental experience to patients, and they worry that the progress of the disease will endanger life, thus affecting the quality of life. The scale used in this study was self-completed. Thus, illiterate patients who did not attain primary school education were excluded.

Strengths and limitations of the study

This study was based on the quality of life scale for cervical cancer patients (QLICP-CE V2.0) and explored the indicative roles of general demographic factors and some clinical indicators on their quality of life. The QLICP-CE(V2.0) was developed by modular approach with combination of the general module QLICD-GM and a specific module for cervical cancer. Contrast to other QOL instruments, the QLICP-CE(V2.0) has several advantages [13, 14]. First, it can compare HRQOL across diseases by the general module and also capture the symptoms and side effects by the specific module, demonstrating both generic and specific properties. Second, it consists of a moderate number of items with a clear hierarchical structure (items→ facets→ domains→ overall) so that mean scores can be computed not only at the domain and the overall levels but also at the different facet levels to detect changes in greater detail. Therefore, it could better reflect the quality of life in patients with cervical cancer and is sensitive to the affecting factors.

There are some limitations to this study. First, the patients were sampled only in Guangdong and Yunnan provinces, and the sample may not be fully representative of the general population of Chinese breast cancer patients. Second, there may be other potential factors that affect the QOL of breast cancer patients, which were not comprehensively explored in this study. Besides, only statistically significant variables in the single factor analysis were included in the multiple linear regression model considering there were too many independent variables relative to the sample size and the selection of too many variables would have resulted in a decrease in precision due to the excessive amount of calculations. And thus it could have resulted in omission of some variables with a large interaction and a small individual effect. Last but not least, this study focused on an initial exploration of the demographic and clinical characteristics of factors that may influence the QOL of breast cancer patients, the mechanisms of QOL influencing factors remain unclear especially clinical biochemical indexes, which still need to be further studied.

Suggestions for further research

On the basis of this study, the multi-center large-sample survey will continue to be conducted to explore more factors. Future studies should investigate why quality of life is linked to socio-demographic and clinical factors, and also explore their mechanisms. In future studies, we will try our best to take objective factors and subjective factors (such as personality characteristics, psychological resilience, etc.) into account to explore the factors affecting the quality of life of patients with cervical cancer. It will provide theoretical support for improving the quality of life of patients with cervical cancer.

Conclusions

In this study, the total score of the scale was moderate, suggesting that the overall quality of life of patients with cervical cancer who received active treatment after the disease was fairly good. Both the disease and its treatment cause prolonged and inevitable physical pain, patients had the lowest quality-of-life scores in the PHD. The quality of life is related to many factors, not only with the characteristics of demographic sociology, but also with some objective clinical indicators. Marital status, clinical staging, and educational level are the factors that affect the quality of life of patients with cervical cancer. The study also found that potassium ion concentration, red blood cell count and creatinine concentration also had important effects on quality of life in patients with cervical cancer, which are biochemical indicators that have not been reported before. However, in this study, external factors such as clinical staging and education level were mainly considered, while the influence of internal factors such as personality and hobbies on patients’ quality of life was not considered. The results of this study can set the ground work to adopt more targeted individual treatment and intervention measures, so as to improve the quality of life of patients with cervical cancer.

Data availability

The datasets generated and/or analysed during the current study are not publicly available due to confidentiality and privacy, but are available from the corresponding author on reasonable request.

Abbreviations

QLICP-GM:

Quality of Life Instruments for Cancer Patients-General Module

QLICP-CE:

Quality of Life Instruments for Cancer Patients-Cervical Cancer

TOT:

Total

PHD:

Physical domain

PSD:

Psychological domain

SOD:

Social domain

SSD:

Common symptoms and side effect domain

SPD:

Specific domain

CGD:

Common general domain

FACT-Cx:

Functional Assessment of Cancer Therapy-Cervix

EORTC QLQ-Cx:

European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire-Cervical Cancer Module

References

  1. Tang M. Research progress on epidemiology and risk factors of cervical cancer. Cardiovasc Disease Electron J Integr Traditional Chin Western Med. 2017;5:18–9.

    Google Scholar 

  2. Huang J, Deng Y, Boakye D, Tin MS, Lok V, Zhang L, Lucero-Prisno DE 3rd, Xu W, Zheng ZJ, Elcarte E, Withers M, Wong MCS. Global distribution, risk factors, and recent trends for cervical cancer: a worldwide country-level analysis. Gynecol Oncol. 2022;164(1):85–92.

    Article  PubMed  Google Scholar 

  3. Bray F, Ferlay J, Soerjomataram I,Siegel RL, Torre LA,Jemal A. Global cancer statistics 2018: GLOB OCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer Clin. 2018;68:394–424.

    Article  Google Scholar 

  4. Liu ZC, Li ZX, Zhang Y, Zhou T, Zhang JY, You WC,Pan KF, Li WQ. Interpretation of global cancer statistics report 2020. J Integr Oncol. 2021;7:1–14.

    Google Scholar 

  5. Cai HL, Yuan WG,Sun HX. Prevalence and prevention strategies of cervical cancer in the world and China. Chin Clin Oncol. 2023;28(01):90–3.

    Google Scholar 

  6. Laili R, Tuti P, ,Kusman I, ,Nurhiday K, Agustina H. Social support and quality of life in cancer patients: a study of palliative shelters in West Java. Matrix Sci Med. 2022;6(2):40–7.

    Article  Google Scholar 

  7. Vikas G, Sameer R, Kaushal K,Bhoriwa S, Barwad A,Dhamija E,Upadhyay A,Gamangatti S. Health-related quality of life (HRQoL), anxiety, and depression in patients with desmoid type fibromatosis. Supportive care cancer 2022;30(12):10089–98.

  8. Hare CJ, Crangle C, McGarragle K, Ferguson SE, Hart TL. Change in cancer-related fatigue over time predicts health-related quality of life in ovarian cancer patients. Gynecol Oncol. 2022;166(3):487–93.

    Article  PubMed  Google Scholar 

  9. Hanprasertpong J, Geater A,Jiamset I A,Padungkul L,Hirunkajonpan P,Songhong N. Fear of cancer recurrence and its predictors among cervical cancer survivors. Journal of Gynecologic Oncology. 2017;28:e72.

  10. Yumi L, Myong CL,Se IK, Jungnam J, Dong L, Sang-Yoon P. Comparison of quality of life and sexuality between cervical cancer survivors and healthy women. Cancer Res Treat. 2016;4 8:1321–9.

    Google Scholar 

  11. Wan C, Yang Z, Meng Q, Feng C, Wang H, Tang X, et al. Development and validation of the general module of the system of quality of life instruments for cancer patients. Int J Cancer. 2008;122(1):190–6.

    Article  CAS  PubMed  Google Scholar 

  12. Li F, Zhou J, Wan C, Yang Z, Liang Q, Li W, et al. Development and validation of the breast Cancer Scale QLICP-BR V2.0 based on classical test theory and generalizability theory. Front Oncol. 2022;12:915103.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Zhang XQ, Wan CH,LU YB, Yang HY, LUO JH, Huang Y, Meng Q. Development and evaluation of quality of life instruments for cancer patients with cervical cancer. China Cancer. 2009;18:183–6.

    CAS  Google Scholar 

  14. Zhou JL, Zhou L, Yang Z,Wan CH,Yang HY,Chen HW, Meng Q,Hou XF. Quality of life in patients with cervical cancer and their clinical objective indicators based on QLICP-CE(2.0):a canonical correlation analysis. Mod Prev Med. 2020;47:3243–6.

    CAS  Google Scholar 

  15. Chen HY, Wan CH, Yang zheng,Liao JR, Cun YL, Liang QL. Item analysis on quality of life instruments for cervical cancer patients-QLICP-CE-(V2.0) based on classical test theory and item response theory. Mod Prev Med 2021;48(09):1586–91.

  16. Chen HF, Li Z, Zhao M, Ding SR, Zhang JP,gu, RY,Luo L. Guo R,Chen B. Factors influencing Quality of Life of Patients with Cervical Cancer. Chinese Primary Health Care. 2022;36(03):57–59.

  17. Ruan F, Yuan Y, Liu M, Chen X. Analysis of life quality and influencing factors of women with two cancers in rural areas. Chin J Health Stat. 2020;37(06):802–4.

    Google Scholar 

  18. GBD 2019 Diseases and Injuries GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study. Lancet. 2020;396(10258):1204–22.

    Article  Google Scholar 

  19. Maria L, Ioannis T, Dimitra P, Athanasioset K, Stefanos T, Konstantinos V, Angeliki K, Konstantinos A. Quality of life in oral Cancer patients in Greek clinical practice: a Cohort Study. J Clin Med 2022;11(23):7235–7235.

  20. Zhang N. Yuan Y.National guidelines for diagnosis and treatment of cervical cancer 2022 in China(English version.) Chin J Cancer Res 2022;34(03):256–69.

  21. Jin RR, Qian HZ,Yong S, Yuan DL,Bao JJ,Zhou HL,Chen M, Huang JX, Yu H. The prevalence and genotype distribution of human papillomaviruses among women in Taizhou. China Med. 2019;98(39):e17293.

    Google Scholar 

  22. MSN SSK, MdPhd HSE, MBBS GD. Health-related quality of life in prostate cancer patients’ – treatment comparisons. Int J Urol Nurs 2017,11(2):98–105.

  23. Yeon KP, Minju K, Ok YY. Factors relating to quality of life in Korean breast Cancer patients: systematic review and Meta-analysis. J Korean Acad Fundamentals Nurs 2017,24(2):95–105.

  24. Dias SDD, Gosalbez B, Alves L, Luz P,Madureira T. EP277 special considerations in quality of life of locally advanced cervical cancer patients. Int J Gynecologic Cancer 2019,29(Suppl 4):A208.

  25. Zhang XR. Correlation study of psychological status, quality of life and cognitive function in patie nts with maintenance hemodialysis [D]. Anhui: Anhui Medical University; 2011.

    Google Scholar 

  26. Liao JY, Yang Z, Yang HY,Wu H. The quality of life in patients with ovarian cancer and correlation analysis with the clinical objective index based on QLICP-OV questionnaire. Mod Prev Med. 2017;44:60–3.

    Google Scholar 

  27. Xu QA, Chang LH,Wan CH,Sun FQ,Xu CZ,Liu Z. Association analysis on clinical objective indicators and patient-reported outcomes in patients with stroke based on the SF-36 Scale. Chin Gene Ral Pract. 2018;21(06):643–7.

    Google Scholar 

  28. Jitender S, Mahajan R, Rathore V, Choudhary R. Quality of life of cancer patients. J Exp Ther Oncol. 2018;12(3):217–21.

    PubMed  Google Scholar 

  29. Hara T, Kogure E, Kubo A. Factors influencing early postoperative health-related quality of life in patients with alimentary system cancer. Support Care Cancer. 2021;29(10):6145–54.

    Article  PubMed  Google Scholar 

  30. Huang LJ, Zhong R. Influence factors of qualities of life in patients with cervical cancer based on QLS-CCP. China J Mod Med. 2021;31:21–6.

    Google Scholar 

  31. Seol KH, Bong SH, Kang DH, Kim JW. Factors Associated with the quality of life of patients with Cancer Undergoing Radiotherapy. Psychiatry Investig. 2021;18(1):80–7.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Zhao M, Pu X, Yan YJ, Zhang S, Long X,Luo L,Li Z. The quality of life in women with cervical cancer and precancerous lesions of Han and ethnic minorities in Southwest China. BMC Cancer. 2021;21(1):1110.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Kumar S, Rana LM, ,Verma K, Sing N,Sharma KA. PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients. PLoS ONE 2017;9(2):e89851.

  34. Xuan H, Yang Z,Wan CH,Liu JP, Yang DL,Luo JH,Meng Q. Analysis of influence factors on quality of life in patients with bladder cancer: applications of QLO-C30 and QLQ-BLM30. J Practical Med. 2015;31:302–6.

    Google Scholar 

  35. Zhao M, Luo L, Zhang CH, Zhang JP, Yuan JY. Healthy-related quality of life in patients with cervical cancer in Southwest China: a cross-sectional study. BMC Health Serv Res. 2021;21(1):841–841.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Tosic Golubovic S, Binic I, Krtinic D, Djordjevic V, Conic I, Gugleta U, Andjelkovic Apostolovic M. Stanojevic M,Kostic J. Risk factors and predictive value of depression and anxiety in Cervical Cancer patients. Med (Kaunas). 2022;58(4):507.

    Google Scholar 

Download references

Acknowledgements

In carrying out this research project, we have received substantial assistance from Prof. Gary Lyman from Hutchinson Institute for Cancer Outcomes Research, and Prof. David Cella, Benjamin J. Arnold at the Center on Outcomes, Research, and Education (CORE), and many staffs at the Central Hospital of Guangdong Nongken, Yunnan Tumor Hospital. We sincerely acknowledge all the support.

Funding

This study is supported by the National Natural Science Foundation of China (71974040, 81273185), the Features Innovative Projects of Key Platform and Major Scientific Research Project of Universities in Guangdong Province (2016KTSCX046, 2017KZDXM040).

Author information

Authors and Affiliations

  1. Key Laboratory for Quality of Life and Psychological Assessment and Intervention, The First Dongguan Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Dongguan, 523808, China

    Huiyan Chen & Chonghua Wan

  2. School of Public Health, Guangdong Medical University, Dongguan, 523808, China

    Lin Zhou & Zheng Yang

  3. School of Nursing, The University of Hong Kong, Hong Kong, China

    Daniel Fong

  4. Yunnan Tumor Hospital, Kunming, 650106, Yunnan Province, China

    Yingli Cun

Authors
  1. Huiyan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lin Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel Fong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yingli Cun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zheng Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chonghua Wan
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

CHW, ZY designed the study. LZ, YLC performed the data collection. HYC performed data analysis and drafted the manuscript. CHW, DF revised the manuscript deeply. All authors contribute to interpreting the data, and have read and approved the final manuscript.

Corresponding authors

Correspondence to Zheng Yang or Chonghua Wan.

Ethics declarations

Ethics approval and consent to participate

The study protocol was approved by the Institutional Review Board (IRB) of the affiliated hospital of Guangdong Medical University (YS2019010). The respondents were voluntary and provided informed’ written consent for participation. All methods were performed in accordance with the relevant guidelines and regulations.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, H., Zhou, L., Fong, D. et al. Quality of life and its related-influencing factors in patients with cervical cancer based on the scale QLICP-CE(V2.0). BMC Women's Health 24, 277 (2024). https://doi.org/10.1186/s12905-024-03068-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12905-024-03068-1

Keywords

BMC Women's Health

ISSN: 1472-6874

Contact us