High protein diets, obesity protects against dying from sepsis, treatment for Alzheimer’s disease moves a step closer
18 Apr 2013
1. High protein diets have no long term beneficial effects on weight loss
A meta-analysis of 15 studies looking into the results of high protein vs low protein diets found that there were no long term differences in weight, waist circumference, fat mass, cholesterol levels, C-reactive protein, blood pressure, or fasting glucose and glycosylated hemoglobin. The high protein diet did seem to improve fasting insulin levels, but overall there were no beneficial (or detrimental) effects to a high protein diet.
Nutrition Journal 2013, 12:48 doi:10.1186/1475-2891-12-48
2. Obesity protects patients dying from sepsis
The obesity paradox, where the very obese have a lower mortality, also applies in sepsis. The reason for this is not clear but the type of infection tended to be different - obese patients with sepsis are more likely to have skin and soft tissue infections and less likely to have pneumonia. Additionally both underweight and obese patients have fewer hemodynamic disturbances and consequently require lower doses of vasopressors.
Critical Care 2013, 17:R72 doi:10.1186/cc12680
3. SPI-1865 treatment for Alzheimer’s disease moves a step closer
SPI-1865 is a small molecule gamma-secretase modulator (GSM). It is bioavailable when taken orally and crosses the blood-brain barrier. It is able to reduce the production of (amyloid b) Ab42 in a dose dependent manner in brain, plasma and CSF, without altering the production of other types of Ab, in both normal mice and a model of Alzheimer’s disease.
Alzheimer's Research & Therapy 2013, 5:19 doi:10.1186/alzrt173
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