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1.

106783
Accesses

Review   Open Access Highly Accessed

Nutrient timing revisited: is there a post-exercise anabolic window?

Alan Albert Aragon, Brad Jon Schoenfeld Journal of the International Society of Sports Nutrition 2013, 10:5 (29 January 2013)

Abstract | Full text | PDF | PubMed

2.

106769
Accesses

Review   Open Access Highly Accessed

A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States

Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga, Richard Deth Clinical Epigenetics 2012, 4:6 (10 April 2012)

Abstract | Full text | PDF | PubMed

3.

87930
Accesses

Research article   Open Access Highly Accessed

The weight of nations: an estimation of adult human biomass

Sarah Walpole, David Prieto-Merino, Phil Edwards, John Cleland, Gretchen Stevens, Ian Roberts BMC Public Health 2012, 12:439 (18 June 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

National food energy requirements are primarily determined by the total biomass of the population rather than the population, suggesting that increasing body mass could have the same implications for world energy requirements as an extra 473 million people on earth.

4.

69452
Accesses

Research article   Open Access Highly Accessed

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.

5.

66148
Accesses

Research article   Open Access Highly Accessed

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013)

Abstract | Full text | PDF | PubMed | 2 comments |  Editor’s summary

A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.

6.

64337
Accesses

Review   Open Access Highly Accessed

Childhood obesity, prevalence and prevention

Mahshid Dehghan, Noori Akhtar-Danesh, Anwar T Merchant Nutrition Journal 2005, 4:24 (2 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

7.

57461
Accesses

Research article   Open Access Highly Accessed

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

Michael A Quail, Miriam Smith, Paul Coupland, Thomas D Otto, Simon R Harris, Thomas R Connor, Anna Bertoni, Harold P Swerdlow, Yong Gu BMC Genomics 2012, 13:341 (24 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Sequencing of four microbial genomes with widely differing GC content is compared on performance using three major new platforms: Ion Torrent PGM, Pacific Biosciences RS, and illumina MiSeq versus Illumina HiSeq system.

8.

56330
Accesses

Research   Open Access Highly Accessed

Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis

Christophe Clec'h, Frédéric Gonzalez, Alexandre Lautrette, Molière Nguile-Makao, Maïté Garrouste-Orgeas, Samir Jamali, Dany Golgran-Toledano, Adrien Descorps-Declere, Frank Chemouni, Rebecca Hamidfar-Roy, Elie Azoulay, Jean-François Timsit Critical Care 2011, 15:R128 (17 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

53853
Accesses

Research   Open Access Highly Accessed

The importance of human resources management in health care: a global context

Stefane M Kabene, Carole Orchard, John M Howard, Mark A Soriano, Raymond Leduc Human Resources for Health 2006, 4:20 (27 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

52179
Accesses

Research article   Open Access Highly Accessed

Relationship between Organizational Culture, Leadership Behavior and Job Satisfaction

Yafang Tsai BMC Health Services Research 2011, 11:98 (14 May 2011)

Abstract | Full text | PDF | PubMed

11.

51030
Accesses

Commentary   Open Access Highly Accessed

How Not to Be a Bioinformatician

Manuel Corpas, Segun Fatumo, Reinhard Schneider Source Code for Biology and Medicine 2012, 7:3 (28 May 2012)

Abstract | Full text | PDF | PubMed | 1 comment

12.

47191
Accesses

Review   Open Access Highly Accessed

Ketogenic diets and physical performance

Stephen D Phinney Nutrition & Metabolism 2004, 1:2 (17 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

46240
Accesses

Research article   Open Access Highly Accessed

Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice

Hiroshi Shimoda, Emi Seki, Michio Aitani BMC Complementary and Alternative Medicine 2006, 6:9 (17 March 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

45533
Accesses

Study protocol   Open Access Highly Accessed

Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol

Anouk GW van Norden, Karlijn F de Laat, Rob AR Gons, Inge WM van Uden, Ewoud J van Dijk, Lucas JB van Oudheusden, Rianne AJ Esselink, Bastiaan R Bloem, Baziel GM van Engelen, Machiel J Zwarts, Indira Tendolkar, Marcel G Olde-Rikkert, Maureen J van der Vlugt, Marcel P Zwiers, David G Norris, Frank-Erik de Leeuw BMC Neurology 2011, 11:29 (28 February 2011)

Abstract | Full text | PDF | PubMed

15.

45160
Accesses

Review   Open Access Highly Accessed

Physical education, school physical activity, school sports and academic performance

François Trudeau, Roy J Shephard International Journal of Behavioral Nutrition and Physical Activity 2008, 5:10 (25 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

44504
Accesses

Review   Open Access Highly Accessed

Food Advertising and Marketing Directed at Children and Adolescents in the US

Mary Story, Simone French International Journal of Behavioral Nutrition and Physical Activity 2004, 1:3 (10 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

43138
Accesses

Commentary   Open Access Highly Accessed

The Hospital Anxiety And Depression Scale

R Philip Snaith Health and Quality of Life Outcomes 2003, 1:29 (1 August 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

42735
Accesses

Review   Open Access Highly Accessed

ISSN exercise & sport nutrition review: research & recommendations

Richard B Kreider, Colin D Wilborn, Lem Taylor, Bill Campbell, Anthony L Almada, Rick Collins, Mathew Cooke, Conrad P Earnest, Mike Greenwood, Douglas S Kalman, Chad M Kerksick, Susan M Kleiner, Brian Leutholtz, Hector Lopez, Lonnie M Lowery, Ron Mendel, Abbie Smith, Marie Spano, Robert Wildman, Darryn S Willoughby, Tim N Ziegenfuss, Jose Antonio Journal of the International Society of Sports Nutrition 2010, 7:7 (2 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

42346
Accesses

Research   Open Access Highly Accessed

Sex & vision I: Spatio-temporal resolution

Israel Abramov, James Gordon, Olga Feldman, Alla Chavarga Biology of Sex Differences 2012, 3:20 (4 September 2012)

Abstract | Full text | PDF | PubMed

20.

40784
Accesses

Review   Open Access Highly Accessed

Dietary protein intake and renal function

William F Martin, Lawrence E Armstrong, Nancy R Rodriguez Nutrition & Metabolism 2005, 2:25 (20 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

38036
Accesses

Debate   Open Access Highly Accessed

A theory of organizational readiness for change

Bryan J Weiner Implementation Science 2009, 4:67 (19 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

37776
Accesses

Research   Open Access Highly Accessed

A survey of energy drink consumption patterns among college students

Brenda M Malinauskas, Victor G Aeby, Reginald F Overton, Tracy Carpenter-Aeby, Kimberly Barber-Heidal Nutrition Journal 2007, 6:35 (31 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

37522
Accesses

Commentary   Free Highly Accessed

Prediction of fluid challenge effect: filling pressure when left ventricular function is abnormal, diastolic volume when left ventricular function is normal

Didier Payen Critical Care 2011, 15:139 (24 March 2011)

Abstract | Full text | PDF | PubMed

24.

37093
Accesses

Research article   Open Access Highly Accessed

Relationship between commuting and health outcomes in a cross-sectional population survey in southern Sweden

Erik Hansson, Kristoffer Mattisson, Jonas Björk, Per-Olof Östergren, Kristina Jakobsson BMC Public Health 2011, 11:834 (31 October 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Commuters report poor sleep quality, exhaustion and low self-rated health, with those travelling by public transport also experiencing more financial stress, suggesting that these negative effects should be considered when discussing policies aimed at increasing workforce mobility.

25.

35500
Accesses

Opinion   Open Access Highly Accessed

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.

26.

34179
Accesses

Method   Open Access Highly Accessed

Differential expression analysis for sequence count data

Simon Anders, Wolfgang Huber Genome Biology 2010, 11:R106 (27 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000 Biology |  Editor’s summary

DEseq allows the determination of differential expression of read count data from RNA-seq or ChIP-seq experiments

27.

33876
Accesses

Research article   Open Access Highly Accessed

Mental illness related disparities in diabetes prevalence, quality of care and outcomes: a population-based longitudinal study

Qun Mai, C D'Arcy J Holman, Frank M Sanfilippo, Jonathan D Emery, David B Preen BMC Medicine 2011, 9:118 (1 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Disparities in diabetes prevalence and the quality and outcome of diabetic care of those with mental illness and those without in Australia highlights the need for better, more integrated care for this population.

28.

32544
Accesses

Review   Open Access Highly Accessed

A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef

Cynthia A Daley, Amber Abbott, Patrick S Doyle, Glenn A Nader, Stephanie Larson Nutrition Journal 2010, 9:10 (10 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

32443
Accesses

Review   Open Access Highly Accessed

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Michael S Donaldson Nutrition Journal 2004, 3:19 (20 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

30.

32427
Accesses

Research article   Open Access Highly Accessed

Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study

Riccardo Polosa, Pasquale Caponnetto, Jaymin B Morjaria, Gabriella Papale, Davide Campagna, Cristina Russo BMC Public Health 2011, 11:786 (11 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

31885
Accesses

Software   Open Access Highly Accessed

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg Genome Biology 2009, 10:R25 (4 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes.

32.

31694
Accesses

Research   Open Access Highly Accessed

The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide

Monica H Carlsen, Bente L Halvorsen, Kari Holte, Siv K Bøhn, Steinar Dragland, Laura Sampson, Carol Willey, Haruki Senoo, Yuko Umezono, Chiho Sanada, Ingrid Barikmo, Nega Berhe, Walter C Willett, Katherine M Phillips, David R Jacobs, Rune Blomhoff Nutrition Journal 2010, 9:3 (22 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

31630
Accesses

Review   Open Access Highly Accessed

Applications of nanoparticles in biology and medicine

OV Salata Journal of Nanobiotechnology 2004, 2:3 (30 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

31544
Accesses

Technical advance   Open Access Highly Accessed

A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format

Tanis R Fenton BMC Pediatrics 2003, 3:13 (16 December 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

31518
Accesses

Review   Open Access Highly Accessed

Cutaneous lesions of the external ear

Michael Sand, Daniel Sand, Dominik Brors, Peter Altmeyer, Benno Mann, Falk G Bechara Head & Face Medicine 2008, 4:2 (8 February 2008)

Abstract | Full text | PDF | PubMed

36.

31388
Accesses

Commentary   Open Access Highly Accessed

International Society of Sports Nutrition position stand: creatine supplementation and exercise

Thomas W Buford, Richard B Kreider, Jeffrey R Stout, Mike Greenwood, Bill Campbell, Marie Spano, Tim Ziegenfuss, Hector Lopez, Jamie Landis, Jose Antonio Journal of the International Society of Sports Nutrition 2007, 4:6 (30 August 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

31296
Accesses

Commentary   Open Access Highly Accessed

A tutorial on pilot studies: the what, why and how

Lehana Thabane, Jinhui Ma, Rong Chu, Ji Cheng, Afisi Ismaila, Lorena P Rios, Reid Robson, Marroon Thabane, Lora Giangregorio, Charles H Goldsmith BMC Medical Research Methodology 2010, 10:1 (6 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

31145
Accesses

Research   Open Access Highly Accessed

Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers

Khan Sajid, Kamal Chaouachi, Rubaida Mahmood Harm Reduction Journal 2008, 5:19 (24 May 2008)

Abstract | Full text | PDF | PubMed | 8 comments

39.

30685
Accesses

Review   Open Access Highly Accessed

Molecular dynamics simulations and drug discovery

Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.

40.

30546
Accesses

Research   Open Access Highly Accessed

Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group

Rinaldo Bellomo, Claudio Ronco, John A Kellum, Ravindra L Mehta, Paul Palevsky, the ADQI workgroup Critical Care 2004, 8:R204-R212 (24 May 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000

41.

30425
Accesses

Review   Open Access Highly Accessed

Weight Science: Evaluating the Evidence for a Paradigm Shift

Linda Bacon, Lucy Aphramor Nutrition Journal 2011, 10:9 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

42.

30072
Accesses

Review   Open Access Highly Accessed

Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism

Tyler A Churchward-Venne, Nicholas A Burd, Stuart M Phillips Nutrition & Metabolism 2012, 9:40 (17 May 2012)

Abstract | Full text | PDF | PubMed

43.

29502
Accesses

Research   Open Access Highly Accessed

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman Genome Biology 2002, 3:research0034-research0034.11 (18 June 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of a single gene for normalization leads to relatively large errors in a significant proportion of samples tested.

44.

29391
Accesses

Review   Open Access Highly Accessed

Nutritional therapies for mental disorders

Shaheen E Lakhan, Karen F Vieira Nutrition Journal 2008, 7:2 (21 January 2008)

Abstract | Full text | PDF | PubMed | 1 comment

45.

29128
Accesses

Review   Open Access Highly Accessed

Fructose, insulin resistance, and metabolic dyslipidemia

Heather Basciano, Lisa Federico, Khosrow Adeli Nutrition & Metabolism 2005, 2:5 (21 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

46.

28899
Accesses

Research   Open Access Highly Accessed

The health impacts of globalisation: a conceptual framework

Maud MTE Huynen, Pim Martens, Henk BM Hilderink Globalization and Health 2005, 1:14 (3 August 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

28340
Accesses

Commentary   Open Access Highly Accessed

International Society of Sports Nutrition position stand: protein and exercise

Bill Campbell, Richard B Kreider, Tim Ziegenfuss, Paul La Bounty, Mike Roberts, Darren Burke, Jamie Landis, Hector Lopez, Jose Antonio Journal of the International Society of Sports Nutrition 2007, 4:8 (26 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

28190
Accesses

Review   Open Access Highly Accessed

Protein timing and its effects on muscular hypertrophy and strength in individuals engaged in weight-training

Matthew Stark, Judith Lukaszuk, Aimee Prawitz, Amanda Salacinski Journal of the International Society of Sports Nutrition 2012, 9:54 (14 December 2012)

Abstract | Full text | PDF | PubMed

49.

27863
Accesses

Methodology article   Open Access Highly Accessed

Statistical analysis of real-time PCR data

Joshua S Yuan, Ann Reed, Feng Chen, C Neal Stewart BMC Bioinformatics 2006, 7:85 (22 February 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

27833
Accesses

Review   Open Access Highly Accessed

Rate of complications in scoliosis surgery – a systematic review of the Pub Med literature

Hans-Rudolf Weiss, Deborah Goodall Scoliosis 2008, 3:9 (5 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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