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51.

27292
Accesses

Review   Open Access Highly Accessed

A review of trisomy X (47,XXX)

Nicole R Tartaglia, Susan Howell, Ashley Sutherland, Rebecca Wilson, Lennie Wilson Orphanet Journal of Rare Diseases 2010, 5:8 (11 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

52.

26405
Accesses

Review   Free Highly Accessed

Clinical review: Acid–base abnormalities in the intensive care unit – part II

Lewis J Kaplan, Spiros Frangos Critical Care 2005, 9:198-203 (20 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

53.

26308
Accesses

Question and Answer   Open Access Highly Accessed

Q&A: 'Toxic' effects of sugar: should we be afraid of fructose?

Luc Tappy BMC Biology 2012, 10:42 (21 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Before the colonial era of sugar plantations we consumed, on average, about 15-fold less fructose than we do today. Luc Tappy explains, in question and answer format, the special features of fructose metabolism and discusses the evidence that high fructose intake has contributed to the current epidemic of obesity and metabolic disease.

54.

26257
Accesses

Review   Open Access Highly Accessed

Apple phytochemicals and their health benefits

Jeanelle Boyer, Rui Liu Nutrition Journal 2004, 3:5 (12 May 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

55.

25993
Accesses

Research article   Open Access Highly Accessed

Delta neutrophil index as an early marker of disease severity in critically ill patients with sepsis

Byung Park, Young Kang, Moo Park, Won Jung, Su Lee, Sang Lee, Song Kim, Se Kim, Joon Chang, Ji Jung, Young Kim BMC Infectious Diseases 2011, 11:299 (1 November 2011)

Abstract | Full text | PDF | PubMed

56.

25853
Accesses

Methodology   Open Access Highly Accessed

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Elaine O Petrof, Gregory B Gloor, Stephen J Vanner, Scott J Weese, David Carter, Michelle C Daigneault, Eric M Brown, Kathleen Schroeter, Emma Allen-Vercoe Microbiome 2013, 1:3 (9 January 2013)

Abstract | Full text | PDF |  Editor’s summary

A super-probiotic synthetic stool, composed of 33 different bacterial strains, was developed and used to treat two patients with severe C. difficile infection. The probiotic bacteria could still be detected up to six months after inoculation.

57.

25813
Accesses

Review   Open Access Highly Accessed

The Quality of Life Scale (QOLS): Reliability, Validity, and Utilization

Carol S Burckhardt, Kathryn L Anderson Health and Quality of Life Outcomes 2003, 1:60 (23 October 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

58.

25790
Accesses

Research article   Open Access Highly Accessed

A qualitative study of nursing student experiences of clinical practice

Farkhondeh Sharif, Sara Masoumi BMC Nursing 2005, 4:6 (9 November 2005)

Abstract | Full text | PDF | PubMed

59.

25407
Accesses

Review   Open Access Highly Accessed

Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review

Gabriel J Wilson, Jacob M Wilson, Anssi H Manninen Nutrition & Metabolism 2008, 5:1 (3 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

60.

24997
Accesses

Research   Open Access Highly Accessed

Functional analysis of transcription factor binding sites in human promoters

Troy W Whitfield, Jie Wang, Patrick J Collins, E Christopher Partridge, Shelley Aldred, Nathan D Trinklein, Richard M Myers, Zhiping Weng Genome Biology 2012, 13:R50 (5 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

TFBSs are predicted from ENCODE data, and experiments in four cell lines find 70% to be functional

61.

24953
Accesses

Question and Answer   Open Access Highly Accessed

Q&A: What is the Golgi apparatus, and why are we asking?

Sean Munro BMC Biology 2011, 9:63 (30 September 2011)

Full text | PDF | PubMed | 2 comments |  Editor’s summary

Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.

62.

24756
Accesses

Research   Open Access Highly Accessed

Management of bleeding following major trauma: an updated European guideline

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Philip F Stahel, Jean-Louis Vincent, Donat R Spahn Critical Care 2010, 14:R52 (6 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

63.

24724
Accesses

Debate   Open Access Highly Accessed

Wikis, blogs and podcasts: a new generation of Web-based tools for virtual collaborative clinical practice and education

Maged Boulos, Inocencio Maramba, Steve Wheeler BMC Medical Education 2006, 6:41 (15 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

64.

24331
Accesses

Research   Open Access Highly Accessed

Social and psychological factors affecting eating habits among university students in a Malaysian medical school: a cross-sectional study

Kurubaran Ganasegeran, Sami AR Al-Dubai, Ahmad M Qureshi, Al-abed AA Al-abed, Rizal AM, Syed M Aljunid Nutrition Journal 2012, 11:48 (18 July 2012)

Abstract | Full text | PDF | PubMed

65.

23901
Accesses

Review   Open Access Highly Accessed

Metagenomics - a guide from sampling to data analysis

Torsten Thomas, Jack Gilbert, Folker Meyer Microbial Informatics and Experimentation 2012, 2:3 (9 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

66.

23594
Accesses

Review   Free Highly Accessed

From RNA-seq reads to differential expression results

Alicia Oshlack, Mark D Robinson, Matthew D Young Genome Biology 2010, 11:220 (22 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Many methods and tools are available for preprocessing high-throughput RNA sequencing data and detecting differential expression.

67.

23500
Accesses

Research article   Open Access Highly Accessed

Open access versus subscription journals: a comparison of scientific impact

Bo-Christer Björk, David Solomon BMC Medicine 2012, 10:73 (17 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000 Biology |  Editor’s summary

The scientific impact of articles published in open access (OA) and subscription journals are similar when journal discipline, location of publisher and age of publication are compared, which is particularly true in medicine and health, where OA journals founded in the last 10 years receive on average as many citations as subscription journals launched during the same time.

68.

23220
Accesses

Review   Open Access

Diet induced thermogenesis

Klaas R Westerterp Nutrition & Metabolism 2004, 1:5 (18 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

69.

23022
Accesses

Review   Open Access Highly Accessed

Toxic epidermal necrolysis and Stevens-Johnson syndrome

Thomas Harr, Lars E French Orphanet Journal of Rare Diseases 2010, 5:39 (16 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

70.

22998
Accesses

Research   Open Access Highly Accessed

Associations among 25-year trends in diet, cholesterol and BMI from 140,000 observations in men and women in Northern Sweden

Ingegerd Johansson, Lena Nilsson, Birgitta Stegmayr, Kurt Boman, Göran Hallmans, Anna Winkvist Nutrition Journal 2012, 11:40 (11 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A study of changing diet habits in Northern Sweden, comprising 140,000 observations over 30 years, found that adherence to low carbohydrate-high fat diets increased after heavy promotion in the media, leading to increased serum cholesterol and associated cardiovascular risk.

71.

22935
Accesses

Research article   Open Access Highly Accessed

Genetic variants associated with breast size also influence breast cancer risk

Nicholas Eriksson, Geoffrey M Benton, Chuong B Do, Amy K Kiefer, Joanna L Mountain, David A Hinds, Uta Francke, Joyce Y Tung BMC Medical Genetics 2012, 13:53 (30 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A genomewide association study reveals seven single-nucleotide polymorphisms associated with differences in womens` breast size during normal development, of which two have been previously linked with the risk of breast cancer.

72.

22705
Accesses

Research article   Open Access Highly Accessed

Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews

Beverley J Shea, Jeremy M Grimshaw, George A Wells, Maarten Boers, Neil Andersson, Candyce Hamel, Ashley C Porter, Peter Tugwell, David Moher, Lex M Bouter BMC Medical Research Methodology 2007, 7:10 (15 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

73.

22274
Accesses

Research article   Open Access Highly Accessed

Ketogenic diet does not affect strength performance in elite artistic gymnasts

Antonio Paoli, Keith Grimaldi, Dominic D’Agostino, Lorenzo Cenci, Tatiana Moro, Antonino Bianco, Antonio Palma Journal of the International Society of Sports Nutrition 2012, 9:34 (26 July 2012)

Abstract | Full text | PDF | PubMed | 1 comment

74.

21889
Accesses

Review   Open Access Highly Accessed

Cancer as a metabolic disease

Thomas N Seyfried, Laura M Shelton Nutrition & Metabolism 2010, 7:7 (27 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

75.

21741
Accesses

Research   Open Access Highly Accessed

Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors

Kevin Y Yip, Chao Cheng, Nitin Bhardwaj, James B Brown, Jing Leng, Anshul Kundaje, Joel Rozowsky, Ewan Birney, Peter Bickel, Michael Snyder, Mark Gerstein Genome Biology 2012, 13:R48 (5 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Machine learning analysis of ENCODE data for 100 transcription factors reveals six classes of genomic regions

76.

21674
Accesses

Review   Open Access Highly Accessed

Beta-thalassemia

Renzo Galanello, Raffaella Origa Orphanet Journal of Rare Diseases 2010, 5:11 (21 May 2010)

Abstract | Full text | PDF | PubMed

77.

21530
Accesses

Review   Open Access Highly Accessed

Critical care management of severe traumatic brain injury in adults

Samir H Haddad, Yaseen M Arabi Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:12 (3 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

78.

21162
Accesses

Review   Open Access Highly Accessed

International Society of Sports Nutrition position stand: energy drinks

Bill Campbell, Colin Wilborn, Paul La Bounty, Lem Taylor, Mike T Nelson, Mike Greenwood, Tim N Ziegenfuss, Hector L Lopez, Jay R Hoffman, Jeffrey R Stout, Stephen Schmitz, Rick Collins, Doug S Kalman, Jose Antonio, Richard B Kreider Journal of the International Society of Sports Nutrition 2013, 10:1 (3 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A systematic review on energy drinks, from the International Society of Sports Nutrition.

79.

21046
Accesses

Research   Open Access Highly Accessed

Modeling gene expression using chromatin features in various cellular contexts

Xianjun Dong, Melissa C Greven, Anshul Kundaje, Sarah Djebali, James B Brown, Chao Cheng, Thomas R Gingeras, Mark Gerstein, Roderic Guigó, Ewan Birney, Zhiping Weng Genome Biology 2012, 13:R53 (5 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Models for linking gene expression with chromatin features vary according to cellular context and RNA measurement method

80.

21027
Accesses

Research article   Open Access Highly Accessed

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

John A Babraj, Niels BJ Vollaard, Cameron Keast, Fergus M Guppy, Greg Cottrell, James A Timmons BMC Endocrine Disorders 2009, 9:3 (28 January 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Low-volume, high-intensity exercise improves insulin action in sedentary males and may prove to be an efficient way of reducing risk factors for metabolic disease in those with little time for conventional high volume regimes.

81.

20852
Accesses

Research   Open Access Highly Accessed

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn, Magali Cucchiarini Stem Cell Research & Therapy 2012, 3:22 (28 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Transfer of SOX9 via replication-defective recombinant adeno-associated virus (rAAV) vector enhances the chondrogenic potential of human mesenchymal stem cells, with potential for future therapeutic applications to restore articular cartilage defects.

82.

20839
Accesses

Correspondence   Open Access Highly Accessed

Mistaken Identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics

Barry R Zeeberg, Joseph Riss, David W Kane, Kimberly J Bussey, Edward Uchio, W Marston Linehan, J Carl Barrett, John N Weinstein BMC Bioinformatics 2004, 5:80 (23 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 7 comments

83.

20799
Accesses

Hypothesis   Open Access Highly Accessed

Musical beauty and information compression: Complex to the ear but simple to the mind?

Nicholas J Hudson BMC Research Notes 2011, 4:9 (20 January 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Despite their apparent complexity, many musical masterpieces can be reduced to simple patterns by the brain, and this "compressibility" may play a role in the pleasure we have listening to them, a hypothesis suggests.

84.

20463
Accesses

Research article   Open Access Highly Accessed

Cross-national epidemiology of DSM-IV major depressive episode

Evelyn Bromet, Laura Andrade, Irving Hwang, Nancy A Sampson, Jordi Alonso, Giovanni de Girolamo, Ron de Graaf, Koen Demyttenaere, Chiyi Hu, Noboru Iwata, Aimee N Karam, Jagdish Kaur, Stanislav Kostyuchenko, Jean-Pierre Lépine, Daphna Levinson, Herbert Matschinger, Maria Mora, Mark Browne, Jose Posada-Villa, Maria Viana, David R Williams, Ronald C Kessler BMC Medicine 2011, 9:90 (26 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Major depression is a significant public health problem around the globe which affects women twice as commonly as men and is most strongly correlated with being separated, divorced or widowed.

85.

20342
Accesses

Review   Open Access Highly Accessed

Creatine supplementation with specific view to exercise/sports performance: an update

Robert Cooper, Fernando Naclerio, Judith Allgrove, Alfonso Jimenez Journal of the International Society of Sports Nutrition 2012, 9:33 (20 July 2012)

Abstract | Full text | PDF | PubMed

86.

20157
Accesses

Research article   Open Access Highly Accessed

The purple line as a measure of labour progress: a longitudinal study

Ashley Shepherd, Helen Cheyne, Susan Kennedy, Colette McIntosh, Maggie Styles, Catherine Niven BMC Pregnancy and Childbirth 2010, 10:54 (16 September 2010)

Abstract | Full text | PDF | PubMed

87.

19969
Accesses

Case Report   Open Access Highly Accessed

Overabundant milk supply: an alternative way to intervene by full drainage and block feeding

Caroline GA van Veldhuizen-Staas International Breastfeeding Journal 2007, 2:11 (29 August 2007)

Abstract | Full text | PDF | PubMed | 1 comment

88.

19823
Accesses

Review   Free

Weaning from mechanical ventilation

Inmaculada Alía, Andrés Esteban Critical Care 2000, 4:72-80 (18 February 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

89.

19658
Accesses

Review   Open Access Highly Accessed

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

Rainer J Klement, Ulrike Kämmerer Nutrition & Metabolism 2011, 8:75 (26 October 2011)

Abstract | Full text | PDF | PubMed

90.

19607
Accesses

Research   Open Access Highly Accessed

Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

Cynthia M Kroeger, Monica C Klempel, Surabhi Bhutani, John F Trepanowski, Christine C Tangney, Krista A Varady Nutrition & Metabolism 2012, 9:98 (31 October 2012)

Abstract | Full text | PDF | PubMed

91.

19577
Accesses

Review   Open Access Highly Accessed

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options

Gerhard J Molderings, Stefan Brettner, Jürgen Homann, Lawrence B Afrin Journal of Hematology & Oncology 2011, 4:10 (22 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

92.

19455
Accesses

Review   Open Access Highly Accessed

Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention

Elena Anzivino, Daniela Fioriti, Monica Mischitelli, Anna Bellizzi, Valentina Barucca, Fernanda Chiarini, Valeria Pietropaolo Virology Journal 2009, 6:40 (6 April 2009)

Abstract | Full text | PDF | PubMed

93.

19449
Accesses

Review   Open Access Highly Accessed

The Bhopal disaster and its aftermath: a review

Edward Broughton Environmental Health: A Global Access Science Source 2005, 4:6 (10 May 2005)

Abstract | Full text | PDF | PubMed

94.

19290
Accesses

Brief communication   Open Access Highly Accessed

Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males

Daniel R Moore, Jose Areta, Vernon G Coffey, Trent Stellingwerff, Stuart M Phillips, Louise M Burke, Marilyn Cléroux, Jean-Philippe Godin, John A Hawley Nutrition & Metabolism 2012, 9:91 (16 October 2012)

Abstract | Full text | PDF | PubMed

95.

19246
Accesses

Research   Open Access Highly Accessed

Motivation and job satisfaction among medical and nursing staff in a Cyprus public general hospital

Persefoni Lambrou, Nick Kontodimopoulos, Dimitris Niakas Human Resources for Health 2010, 8:26 (16 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

96.

19191
Accesses

Research   Open Access Highly Accessed

IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation

Judith L Ngondi, Blanche C Etoundi, Christine B Nyangono, Carl MF Mbofung, Julius E Oben Lipids in Health and Disease 2009, 8:7 (2 March 2009)

Abstract | Full text | PDF | PubMed

97.

19185
Accesses

Commentary   Open Access Highly Accessed

A reflection on HIV/AIDS research after 25 years

Robert C Gallo Retrovirology 2006, 3:72 (20 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

98.

19090
Accesses

Method   Open Access Highly Accessed

A scaling normalization method for differential expression analysis of RNA-seq data

Mark D Robinson, Alicia Oshlack Genome Biology 2010, 11:R25 (2 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A novel and empirical method for normalization of RNA-seq data is presented

99.

19088
Accesses

Comment   Subscription Highly Accessed

A 10-step guide to party conversation for bioinformaticians

Alicia Oshlack Genome Biology 2013, 14:104 (29 January 2013)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Alicia Oshlack's 10-step guide to party conversation for bioinformaticians

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