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51.

3198
Accesses

Research   Open Access Highly Accessed

Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers

Khan Sajid, Kamal Chaouachi, Rubaida Mahmood Harm Reduction Journal 2008, 5:19 (24 May 2008)

Abstract | Full text | PDF | PubMed | 8 comments

52.

3189
Accesses

Software   Open Access Highly Accessed

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg Genome Biology 2009, 10:R25 (4 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes.

53.

3162
Accesses

Commentary   Open Access Highly Accessed

International Society of Sports Nutrition position stand: creatine supplementation and exercise

Thomas W Buford, Richard B Kreider, Jeffrey R Stout, Mike Greenwood, Bill Campbell, Marie Spano, Tim Ziegenfuss, Hector Lopez, Jamie Landis, Jose Antonio Journal of the International Society of Sports Nutrition 2007, 4:6 (30 August 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

54.

3170
Accesses

Research   Open Access Highly Accessed

CRISPR-Cas systems target a diverse collection of invasive mobile genetic elements in human microbiomes

Quan Zhang, Mina Rho, Haixu Tang, Thomas G Doak, Yuzhen Ye Genome Biology 2013, 14:R40 (29 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Analysis of CRISPR sequences contained in human metagenomic datasets reveals a variety of different targeted mobile genetic elements

55.

3161
Accesses

Correspondence   Open Access Highly Accessed

A decadal view of biodiversity informatics: challenges and priorities

Alex Hardisty, Dave Roberts, The Biodiversity Informatics Community BMC Ecology 2013, 13:16 (15 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Alex Hardisty and Dave Roberts outline a grand vision for the future of biodiversity research that is based on a fully integrated e-infrastructure, following a huge community consultation effort with the Biodiversity Informatics Community.

56.

3150
Accesses

Review   Open Access Highly Accessed

A novel coronavirus capable of lethal human infections: an emerging picture

Gulfaraz Khan Virology Journal 2013, 10:66 (28 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This timely review summarises the ongoing outbreak of a novel coronavirus (HCoV-EMC), which has caused a number of fatal cases in the UK and Middle East.

57.

3134
Accesses

Review   Open Access Highly Accessed

Apple phytochemicals and their health benefits

Jeanelle Boyer, Rui Liu Nutrition Journal 2004, 3:5 (12 May 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

58.

3138
Accesses

Research   Open Access Highly Accessed

Effect of fruit restriction on glycemic control in patients with type 2 diabetes – a randomized trial

Allan S Christensen, Lone Viggers, Kjeld Hasselström, Søren Gregersen Nutrition Journal 2013, 12:29 (5 March 2013)

Abstract | Full text | PDF | PubMed

59.

3133
Accesses

Debate   Open Access Highly Accessed

Wikis, blogs and podcasts: a new generation of Web-based tools for virtual collaborative clinical practice and education

Maged Boulos, Inocencio Maramba, Steve Wheeler BMC Medical Education 2006, 6:41 (15 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

60.

3133
Accesses

Study protocol   Open Access Highly Accessed

Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol

Anouk GW van Norden, Karlijn F de Laat, Rob AR Gons, Inge WM van Uden, Ewoud J van Dijk, Lucas JB van Oudheusden, Rianne AJ Esselink, Bastiaan R Bloem, Baziel GM van Engelen, Machiel J Zwarts, Indira Tendolkar, Marcel G Olde-Rikkert, Maureen J van der Vlugt, Marcel P Zwiers, David G Norris, Frank-Erik de Leeuw BMC Neurology 2011, 11:29 (28 February 2011)

Abstract | Full text | PDF | PubMed

61.

3134
Accesses

Research article   Open Access Highly Accessed

Ancient origin of somatic and visceral neurons

Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet BMC Biology 2013, 11:53 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The great American palaeontologist and anatomist Alfred Romer speculated that early in animal life, an emerging somatic nervous system, focused on the outside world, struggled to dominate the visceral nervous system that takes care of the internal systems that keep us alive. Jean-François Brunet and colleagues identify the molecular signatures that tell the evolutionary tale of this duality.

62.

3130
Accesses

Review   Open Access Highly Accessed

The Bhopal disaster and its aftermath: a review

Edward Broughton Environmental Health: A Global Access Science Source 2005, 4:6 (10 May 2005)

Abstract | Full text | PDF | PubMed

63.

3132
Accesses

Method   Open Access Highly Accessed

Differential expression analysis for sequence count data

Simon Anders, Wolfgang Huber Genome Biology 2010, 11:R106 (27 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000 Biology |  Editor’s summary

DEseq allows the determination of differential expression of read count data from RNA-seq or ChIP-seq experiments

64.

3122
Accesses

Review   Open Access Highly Accessed

Nutritional therapies for mental disorders

Shaheen E Lakhan, Karen F Vieira Nutrition Journal 2008, 7:2 (21 January 2008)

Abstract | Full text | PDF | PubMed | 1 comment

65.

3108
Accesses

Methodology   Open Access Highly Accessed

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Elaine O Petrof, Gregory B Gloor, Stephen J Vanner, Scott J Weese, David Carter, Michelle C Daigneault, Eric M Brown, Kathleen Schroeter, Emma Allen-Vercoe Microbiome 2013, 1:3 (9 January 2013)

Abstract | Full text | PDF |  Editor’s summary

A super-probiotic synthetic stool, composed of 33 different bacterial strains, was developed and used to treat two patients with severe C. difficile infection. The probiotic bacteria could still be detected up to six months after inoculation.

66.

3074
Accesses

Review   Open Access Highly Accessed

A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef

Cynthia A Daley, Amber Abbott, Patrick S Doyle, Glenn A Nader, Stephanie Larson Nutrition Journal 2010, 9:10 (10 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

67.

3008
Accesses

Review   Open Access Highly Accessed

Applications of nanoparticles in biology and medicine

OV Salata Journal of Nanobiotechnology 2004, 2:3 (30 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

68.

3000
Accesses

Research article   Open Access Highly Accessed

Relationship between Organizational Culture, Leadership Behavior and Job Satisfaction

Yafang Tsai BMC Health Services Research 2011, 11:98 (14 May 2011)

Abstract | Full text | PDF | PubMed

69.

2986
Accesses

Review   Open Access Highly Accessed

Fructose, insulin resistance, and metabolic dyslipidemia

Heather Basciano, Lisa Federico, Khosrow Adeli Nutrition & Metabolism 2005, 2:5 (21 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

70.

2952
Accesses

Research   Open Access Highly Accessed

A human Dravet syndrome model from patient induced pluripotent stem cells

Norimichi Higurashi, Taku Uchida, Christoph Lossin, Yoshio Misumi, Yohei Okada, Wado Akamatsu, Yoichi Imaizumi, Bo Zhang, Kazuki Nabeshima, Masayuki X Mori, Shutaro Katsurabayashi, Yukiyoshi Shirasaka, Hideyuki Okano, Shinichi Hirose Molecular Brain 2013, 6:19 (2 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Induced pluripotent stem cells from the skin of patients with Dravet syndrome show Dravet-like functional impairment when they are converted into neurons, providing an unparalleled insight into the mechanism behind this rare form of infantile-onset epilepsy.

71.

2934
Accesses

Research   Open Access Highly Accessed

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman Genome Biology 2002, 3:research0034-research0034.11 (18 June 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of a single gene for normalization leads to relatively large errors in a significant proportion of samples tested.

72.

2933
Accesses

Research   Open Access

Continuous on-line glucose measurement by microdialysis in a central vein. A pilot study

Christina Blixt, Olav Rooyackers, Bengt Isaksson, Jan Wernerman Critical Care 2013, 17:R87 (11 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A potential new tool for intravascular continuous glucose monitoring in intensive care patients could prevent hypoglycaemia or high glucose variability. 

73.

2902
Accesses

Commentary   Open Access Highly Accessed

It is time to rethink tactics in the fight against malaria

Laurence Slutsker, S Kachur Malaria Journal 2013, 12:140 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

On world malaria day, renowned malariologists from CDC discuss dangers and resilience, despite successful control in many areas, and how we may need to rethink our strategy in order to defeat the parasite.

74.

2874
Accesses

Review   Open Access Highly Accessed

The Quality of Life Scale (QOLS): Reliability, Validity, and Utilization

Carol S Burckhardt, Kathryn L Anderson Health and Quality of Life Outcomes 2003, 1:60 (23 October 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

75.

2873
Accesses

Research   Open Access Highly Accessed

How to interpret the transmissibility of novel influenza A(H7N9): an analysis of initial epidemiological data of human cases from China

Hiroshi Nishiura, Kenji Mizumoto, Keisuke Ejima Theoretical Biology and Medical Modelling 2013, 10:30 (4 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

76.

2862
Accesses

Research   Open Access Highly Accessed

Motor recovery monitoring using acceleration measurements in post acute stroke patients

Jayavardhana Gubbi, Aravinda S. Rao, Kun Fang, Bernard Yan, Marimuthu Palaniswami BioMedical Engineering OnLine 2013, 12:33 (16 April 2013)

Abstract | Provisional PDF | PubMed

77.

2823
Accesses

Research   Open Access Highly Accessed

Noninvasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure: a randomized controlled trial

Susana R Ornico, Suzana M Lobo, Helder S Sanches, Maristela Deberaldini, Luciane T Tófoli, Ana M Vidal, Guilherme P Schettino, Marcelo B Amato, Carlos R Carvalho, Carmen S Barbas Critical Care 2013, 17:R39 (4 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A randomized controlled trial shows that non-invasive ventilation applied immediately after extubation prevents re-intubation and decreases hospital mortality when compared to oxygen mask therapy.

78.

2822
Accesses

Research   Open Access Highly Accessed

Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group

Rinaldo Bellomo, Claudio Ronco, John A Kellum, Ravindra L Mehta, Paul Palevsky, the ADQI workgroup Critical Care 2004, 8:R204-R212 (24 May 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment | F1000

79.

2827
Accesses

Method   Open Access Highly Accessed

jMOSAiCS: joint analysis of multiple ChIP-seq datasets

Xin Zeng, Rajendran Sanalkumar, Emery H Bresnick, Hongda Li, Qiang Chang, Sunduz Keles Genome Biology 2013, 14:R38 (29 April 2013)

Abstract | Provisional PDF |  Editor’s summary

A novel probabilistic method for jointly analyzing multiple ChIP-seq datasets offers an improvement over chromHMM

80.

2812
Accesses

Review   Subscription Highly Accessed

Clinical review: Does it matter which hemodynamic monitoring system is used?

Davinder Ramsingh, Brenton Alexander, Maxime Cannesson Critical Care 2012, 17:208 (5 March 2013)

Abstract | Full text | PDF

81.

2787
Accesses

Research   Open Access Highly Accessed

The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide

Monica H Carlsen, Bente L Halvorsen, Kari Holte, Siv K Bøhn, Steinar Dragland, Laura Sampson, Carol Willey, Haruki Senoo, Yuko Umezono, Chiho Sanada, Ingrid Barikmo, Nega Berhe, Walter C Willett, Katherine M Phillips, David R Jacobs, Rune Blomhoff Nutrition Journal 2010, 9:3 (22 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

82.

2770
Accesses

Research   Open Access Highly Accessed

Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

Cynthia M Kroeger, Monica C Klempel, Surabhi Bhutani, John F Trepanowski, Christine C Tangney, Krista A Varady Nutrition & Metabolism 2012, 9:98 (31 October 2012)

Abstract | Full text | PDF | PubMed

83.

2742
Accesses

Research   Open Access Highly Accessed

Sex & vision I: Spatio-temporal resolution

Israel Abramov, James Gordon, Olga Feldman, Alla Chavarga Biology of Sex Differences 2012, 3:20 (4 September 2012)

Abstract | Full text | PDF | PubMed

84.

2741
Accesses

Case Report   Open Access Highly Accessed

Torsion of ovarian cyst during pregnancy: a case report

Vasavi Kolluru, Rekha Gurumurthy, Venkatasujatha Vellanki, Deshpande Gururaj Cases Journal 2009, 2:9405 (31 December 2009)

Abstract | Full text | PDF | PubMed

85.

2690
Accesses

Research   Open Access Highly Accessed

Systematic biases in DNA copy number originate from isolation procedures

Sebastiaan van Heesch, Michal Mokry, Veronika Boskova, Wade Junker, Rajdeep Mehon, Pim Toonen, Ewart de Bruijn, James D Shull, Timothy J Aitman, Edwin Cuppen, Victor Guryev Genome Biology 2013, 14:R33 (24 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A new study pinpoints the sources of copy number variation biases, highlighting the important issue of sample preparation

86.

2673
Accesses

Research   Open Access Highly Accessed

Long-term effects of low-fat diets either low or high in protein on cardiovascular and metabolic risk factors: a systematic review and meta-analysis

Lukas Schwingshackl, Georg Hoffmann Nutrition Journal 2013, 12:48 (15 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

87.

2673
Accesses

Research   Open Access Highly Accessed

The health impacts of globalisation: a conceptual framework

Maud MTE Huynen, Pim Martens, Henk BM Hilderink Globalization and Health 2005, 1:14 (3 August 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

88.

2666
Accesses

Research article   Open Access Highly Accessed

Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study

Riccardo Polosa, Pasquale Caponnetto, Jaymin B Morjaria, Gabriella Papale, Davide Campagna, Cristina Russo BMC Public Health 2011, 11:786 (11 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

89.

2655
Accesses

Review   Open Access Highly Accessed

Weight Science: Evaluating the Evidence for a Paradigm Shift

Linda Bacon, Lucy Aphramor Nutrition Journal 2011, 10:9 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

90.

2650
Accesses

Research article   Open Access Highly Accessed

Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium

Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen, Mohamed Bentires-Alj Breast Cancer Research 2013, 15:R36 (29 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Early parity in mice alters the genomic signature of a distinct subset of mammary epithelial cells by inducing differentiation and reducing proliferation, ultimately protecting against breast cancer.

91.

2616
Accesses

Research article   Open Access Highly Accessed

Effects of supplemental fish oil on resting metabolic rate, body composition, and salivary cortisol in healthy adults

Eric E Noreen, Michael J Sass, Megan L Crowe, Vanessa A Pabon, Josef Brandauer, Lindsay K Averill Journal of the International Society of Sports Nutrition 2010, 7:31 (8 October 2010)

Abstract | Full text | PDF | PubMed

92.

2597
Accesses

Review   Open Access Highly Accessed

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Michael S Donaldson Nutrition Journal 2004, 3:19 (20 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

93.

2591
Accesses

Research   Open Access Highly Accessed

Volumetric three-dimensional intravascular ultrasound visualization using shape-based nonlinear interpolation

Yonghoon Rim, David D McPherson, Hyunggun Kim BioMedical Engineering OnLine 2013, 12:39 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

94.

2587
Accesses

Commentary   Open Access Highly Accessed

Somatic and visceral nervous systems - an ancient duality

Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.

95.

2580
Accesses

Review   Open Access Highly Accessed

Toxic epidermal necrolysis and Stevens-Johnson syndrome

Thomas Harr, Lars E French Orphanet Journal of Rare Diseases 2010, 5:39 (16 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

96.

2576
Accesses

Research   Open Access Highly Accessed

Consumption of low-fat dairy foods for 6 months improves insulin resistance without adversely affecting lipids or bodyweight in healthy adults: a randomized free-living cross-over study

Todd C Rideout, Christopher P F Marinangeli, Heather Martin, Richard W Browne, Curtis B Rempel Nutrition Journal 2013, 12:56 (2 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

97.

2560
Accesses

Research   Open Access Highly Accessed

Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing

Jason O'Rawe, Tao Jiang, Guangqing Sun, Yiyang Wu, Wei Wang, Jingchu Hu, Paul Bodily, Lifeng Tian, Hakon Hakonarson, W Evan Johnson, Zhi Wei, Kai Wang, Gholson J Lyon Genome Medicine 2013, 5:28 (27 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Head-to-head comparison of widely used variant calling pipelines including SOAP, GATK and Complete Genomics using default parameters reveals discrepancies between the pipelines.

98.

2543
Accesses

Research   Open Access Highly Accessed

Renaissance of base deficit for the initial assessment of trauma patients: a base deficit-based classification for hypovolemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU®

Manuel Mutschler, Ulrike Nienaber, Thomas Brockamp, Arasch Wafaisade, Tobias Fabian, Thomas Paffrath, Bertil Bouillon, Marc Maegele, the TraumaRegister DGU Critical Care 2013, 17:R42 (6 March 2013)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Base deficit (BD)-based shock classification better discriminates the need for early blood transfusion and mortality in severely injured patients than the current Advanced Trauma Life Support (ATLS) protocol.

99.

2526
Accesses

Research article   Open Access

Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study

Dietmar Alf, Michael E Schmidt, Stefan C Siebrecht Journal of the International Society of Sports Nutrition 2013, 10:24 (29 April 2013)

Abstract | Full text | PDF | PubMed

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