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Tumor Angiogenesis

Forming efficient vasculature network, also known as tumor angiogenesis, is a critical hallmark in tumor development. Explorations on its underlying molecular mechanisms have resulted in several novel anti-cancer drugs approved by the Food & Drug Administration (FDA) of the United States. However, the modest survival benefits from anti-angiogenic therapy have forced us to revisit our understanding on tumor angiogenesis. In this special issue of the Chinese Journal of Cancer (CJC), the world leading experts in pathology, molecular biology, pharmacology, and clinical study have contributed their critical thoughts and insightful investigations from different angles to reveal the alternative tumor angiogenesis approaches and potential treatment targets. This special issue is therefore initiating a new era in tumor angiogenesis research, aiming to develop next-generation anti-angiogenic targeted therapy.

Edited by Francesco Pezzella and Chao-Nan Qian

  1. Editorial

    Twenty years after: the beautiful hypothesis and the ugly facts

    The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between ve...

    Francesco Pezzella, Kevin Gatter and Chao-Nan Qian

    Chinese Journal of Cancer 2016 35:22

    Published on: 24 February 2016

  2. Review

    Future options of anti-angiogenic cancer therapy

    In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the a...

    Yihai Cao

    Chinese Journal of Cancer 2016 35:21

    Published on: 15 February 2016

  3. Review

    Mechanisms of vascularization in murine models of primary and metastatic tumor growth

    Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; in...

    Edina Bugyik, Ferenc Renyi-Vamos, Vanessza Szabo, Katalin Dezso, Nora Ecker, Andras Rokusz, Peter Nagy, Balazs Dome and Sandor Paku

    Chinese Journal of Cancer 2016 35:19

    Published on: 12 February 2016

  4. Original Article

    Why some tumours trigger neovascularisation and others don’t: the story thus far

    Angiogenesis is not essential for tumours to develop and expand, as cancer can also grow in a non-angiogenic fashion, but why this type of growth occurs is unknown. Surprisingly, our data from mRNA transcripti...

    Omanma Adighibe, Russell D. Leek, Marta Fernandez-Mercado, Jiangting Hu, Cameron Snell, Kevin C. Gatter, Adrian L. Harris and Francesco Pezzella

    Chinese Journal of Cancer 2016 35:18

    Published on: 12 February 2016

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