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Understanding the links between sex/gender and autism

Series Editor: Meng-Chuan Lai

The male-predominance in the prevalence of autism has many inter-linked implications for understanding the emergence and development of autism. This series, published in Molecular Autism, aims to jointly disentangle the complex relationships between sex/gender differences and autism.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editor declares no competing interests.

  1. Commentary

    Commentary: sex difference differences? A reply to Constantino

    Messinger et al. found a 3.18 odds ratio of male to female ASD recurrence in 1241 prospectively followed high-risk (HR) siblings. Among high-risk siblings (with and without ASD), as well as among 583 low-risk ...

    Daniel S. Messinger, Gregory S. Young, Sara Jane Webb, Sally Ozonoff, Susan E. Bryson, Alice Carter, Leslie Carver, Tony Charman, Katarzyna Chawarska, Suzanne Curtin, Karen Dobkins, Irva Hertz-Picciotto, Ted Hutman, Jana M. Iverson, Rebecca Landa, Charles A. Nelson…

    Molecular Autism 2016 7:31

    Published on: 29 June 2016

  2. Research

    Examining social competence, self-perception, quality of life, and internalizing and externalizing symptoms in adolescent females with and without autism spectrum disorder: a quantitative design including between-groups and correlational analyses

    Adolescent females with an autism spectrum disorder (ASD) are an understudied population, yet are also quite vulnerable, due to the increased complexities of social interaction and increased risk for internali...

    T. Rene Jamison and Jessica Oeth Schuttler

    Molecular Autism 2015 6:53

    Published on: 17 September 2015

  3. Research

    Sex differences in cortical volume and gyrification in autism

    Male predominance is a prominent feature of autism spectrum disorders (ASD), with a reported male to female ratio of 4:1. Because of the overwhelming focus on males, little is known about the neuroanatomical b...

    Marie Schaer, John Kochalka, Aarthi Padmanabhan, Kaustubh Supekar and Vinod Menon

    Molecular Autism 2015 6:42

    Published on: 4 July 2015

  4. Viewpoint

    Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority

    One of the most consistent findings in autism spectrum disorder (ASD) research is a higher rate of ASD diagnosis in males than females. Despite this, remarkably little research has focused on the reasons for t...

    Alycia K Halladay, Somer Bishop, John N Constantino, Amy M Daniels, Katheen Koenig, Kate Palmer, Daniel Messinger, Kevin Pelphrey, Stephan J Sanders, Alison Tepper Singer, Julie Lounds Taylor and Peter Szatmari

    Molecular Autism 2015 6:36

    Published on: 13 June 2015

  5. Research

    Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders

    The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However,...

    Yasuhiro Masuya, Yuko Okamoto, Keisuke Inohara, Yukiko Matsumura, Toru Fujioka, Yuji Wada and Hirotaka Kosaka

    Molecular Autism 2015 6:34

    Published on: 9 June 2015

  6. Review

    Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism

    Several observations support the hypothesis that differences in synaptic and regional cerebral plasticity between the sexes account for the high ratio of males to females in autism. First, males are more susce...

    Laurent Mottron, Pauline Duret, Sophia Mueller, Robert D Moore, Baudouin Forgeot d’Arc, Sebastien Jacquemont and Lan Xiong

    Molecular Autism 2015 6:33

    Published on: 5 June 2015

  7. Research

    Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study

    The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence of sex differences in ASD symptoms and cognitive functioning. The female protective effect hypothesis posi...

    Daniel S. Messinger, Gregory S. Young, Sara Jane Webb, Sally Ozonoff, Susan E. Bryson, Alice Carter, Leslie Carver, Tony Charman, Katarzyna Chawarska, Suzanne Curtin, Karen Dobkins, Irva Hertz-Picciotto, Ted Hutman, Jana M. Iverson, Rebecca Landa, Charles A. Nelson…

    Molecular Autism 2015 6:32

    Published on: 4 June 2015

  8. Research

    Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder

    Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion...

    Christine Wu Nordahl, Ana-Maria Iosif, Gregory S Young, Lee Michael Perry, Robert Dougherty, Aaron Lee, Deana Li, Michael H Buonocore, Tony Simon, Sally Rogers, Brian Wandell and David G Amaral

    Molecular Autism 2015 6:26

    Published on: 13 May 2015

    The Erratum to this article has been published in Molecular Autism 2015 6:39

  9. Research

    Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

    Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and r...

    Valerie W Hu, Tewarit Sarachana, Rachel M Sherrard and Kristen M Kocher

    Molecular Autism 2015 6:7

    Published on: 13 May 2015

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