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Reviews

Recent Reviews published in Genome Biology

This list will be updated with all our new Reviews. Genome Biology publishes reviews that are open access and therefore free to read and share.

  1. Review

    Genetic–epigenetic interactions in cis: a major focus in the post-GWAS era

    Studies on genetic–epigenetic interactions, including the mapping of methylation quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation (hap-ASM), have become a major focus in ...

    Catherine Do, Alyssa Shearer, Masako Suzuki, Mary Beth Terry, Joel Gelernter, John M. Greally and Benjamin Tycko

    Genome Biology 2017 18:120

    Published on: 19 June 2017

  2. Review

    Multi-omics approaches to disease

    High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which ...

    Yehudit Hasin, Marcus Seldin and Aldons Lusis

    Genome Biology 2017 18:83

    Published on: 5 May 2017

  3. Review

    Software tools for visualizing Hi-C data

    High-throughput assays for measuring the three-dimensional (3D) configuration of DNA have provided unprecedented insights into the relationship between DNA 3D configuration and function. Data interpretation fr...

    Galip Gürkan Yardımcı and William Stafford Noble

    Genome Biology 2017 18:26

    Published on: 3 February 2017

  4. Review

    Methylome evolution in plants

    Despite major progress in dissecting the molecular pathways that control DNA methylation patterns in plants, little is known about the mechanisms that shape plant methylomes over evolutionary time. Drawing on ...

    Amaryllis Vidalis, Daniel Živković, René Wardenaar, David Roquis, Aurélien Tellier and Frank Johannes

    Genome Biology 2016 17:264

    Published on: 20 December 2016

    The Erratum to this article has been published in Genome Biology 2017 18:41

  5. Review

    Closing the loop: 3C versus DNA FISH

    Chromosome conformation capture (3C)-based techniques have revolutionized the field of nuclear organization, partly replacing DNA FISH as the method of choice for studying three-dimensional chromosome architec...

    Luca Giorgetti and Edith Heard

    Genome Biology 2016 17:215

    Published on: 19 October 2016

  6. Review

    Tiny microbes, enormous impacts: what matters in gut microbiome studies?

    Many factors affect the microbiomes of humans, mice, and other mammals, but substantial challenges remain in determining which of these factors are of practical importance. Considering the relative effect size...

    Justine Debelius, Se Jin Song, Yoshiki Vazquez-Baeza, Zhenjiang Zech Xu, Antonio Gonzalez and Rob Knight

    Genome Biology 2016 17:217

    Published on: 19 October 2016

  7. Review

    The epigenome: the next substrate for engineering

    We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness...

    Minhee Park, Albert J. Keung and Ahmad S. Khalil

    Genome Biology 2016 17:183

    Published on: 31 August 2016

  8. Review

    Disease vectors in the era of next generation sequencing

    Almost 20 % of all infectious human diseases are vector borne and, together, are responsible for over one million deaths per annum. Over the past decade, the decreasing costs of massively parallel sequencing t...

    David C. Rinker, R. Jason Pitts and Laurence J. Zwiebel

    Genome Biology 2016 17:95

    Published on: 6 May 2016

  9. Review

    Single-cell sequencing in stem cell biology

    Cell-to-cell variation and heterogeneity are fundamental and intrinsic characteristics of stem cell populations, but these differences are masked when bulk cells are used for omic analysis. Single-cell sequenc...

    Lu Wen and Fuchou Tang

    Genome Biology 2016 17:71

    Published on: 15 April 2016

  10. Review

    Evolution of plant genome architecture

    We have witnessed an explosion in our understanding of the evolution and structure of plant genomes in recent years. Here, we highlight three important emergent realizations: (1) that the evolutionary history of

    Jonathan F. Wendel, Scott A. Jackson, Blake C. Meyers and Rod A. Wing

    Genome Biology 2016 17:37

    Published on: 1 March 2016

  11. Review

    A survey of best practices for RNA-seq data analysis

    RNA-sequencing (RNA-seq) has a wide variety of applications, but no single analysis pipeline can be used in all cases. We review all of the major steps in RNA-seq data analysis, including experimental design, ...

    Ana Conesa, Pedro Madrigal, Sonia Tarazona, David Gomez-Cabrero, Alejandra Cervera, Andrew McPherson, Michał Wojciech Szcześniak, Daniel J. Gaffney, Laura L. Elo, Xuegong Zhang and Ali Mortazavi

    Genome Biology 2016 17:13

    Published on: 26 January 2016

    The Erratum to this article has been published in Genome Biology 2016 17:181

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