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Neurometals

Edited by Dr Michael Aschner

Metals have many essential functions in the brain and a large body of evidence supports important roles for altered metal stasis in many brain disorders. Despite this evidence, acceptance of metals as key mediators of brain dysfunction is largely lacking in mainstream biomedicine. The publication of this series on neurometals is a timely recognition of the need to provide focused and highly visible platforms to disseminate the concept of metals in brain function and disease. This is an exciting opportunity to bring neurometals to the forefront of brain research and support our advocacy for metals as key players in all aspects of brain processes, from molecular activity to cognitive function. We hope that this thematic series will provide a node for other researchers across diverse fields to access brain metal research and integrate this into their own programs.


  1. Research article

    Effects on and transfer across the blood-brain barrier in vitro—Comparison of organic and inorganic mercury species

    Transport of methylmercury (MeHg) across the blood-brain barrier towards the brain side is well discussed in literature, while ethylmercury (EtHg) and inorganic mercury are not adequately characterized regardi...

    Hanna Lohren, Julia Bornhorst, Romy Fitkau, Gabriele Pohl, Hans-Joachim Galla and Tanja Schwerdtle

    BMC Pharmacology and Toxicology 2016 17:63

    Published on: 15 December 2016

  2. Editorial

    A greater focus on metals in biomedicine and neuroscience is needed

    Metals have many essential functions in the brain and a large body of evidence supports important roles for altered metal stasis in many brain disorders. However, despite this evidence, acceptance of metals as...

    Anthony R. White

    BMC Pharmacology and Toxicology 2016 17:53

    Published on: 5 November 2016

  3. Review

    “Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

    Manganese (Mn) is an essential heavy metal. However, Mn’s nutritional aspects are paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent advances in identifying me...

    Tanara V. Peres, Maria Rosa C. Schettinger, Pan Chen, Fabiano Carvalho, Daiana S. Avila, Aaron B. Bowman and Michael Aschner

    BMC Pharmacology and Toxicology 2016 17:57

    Published on: 4 November 2016

  4. Research article

    Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans

    All living cells display a rapid molecular response to adverse environmental conditions, and the heat shock protein family reflects one such example. Hence, failing to activate heat shock proteins can impair t...

    Daiana Silva Avila, Alexandre Benedetto, Catherine Au, Julia Bornhorst and Michael Aschner

    BMC Pharmacology and Toxicology 2016 17:54

    Published on: 2 November 2016

  5. Research article

    Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses

    Lead (Pb2+) exposure has been shown to impair presynaptic neurotransmitter release in both in vivo and in vitro model systems. The mechanism by which Pb2+ impairs neurotransmitter release has not been fully eluci...

    Sara Rose Guariglia, Kirstie H. Stansfield, Jennifer McGlothan and Tomas R. Guilarte

    BMC Pharmacology and Toxicology 2016 17:56

    Published on: 2 November 2016

  6. Research article

    Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice

    Metallothioneins (MT) are small proteins, which are crucial for the distribution of heavy and transition metals. Previously, we found in mice that knockout of MT 1 and 2 genes (MTKO) impaired spatial learning ...

    Ann Petro, Hannah G. Sexton, Caroline Miranda, Anit Rastogi, Jonathan H. Freedman and Edward D. Levin

    BMC Pharmacology and Toxicology 2016 17:55

    Published on: 2 November 2016

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