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Global Assays in thrombosis, what are they and why do we need them?

Prof Coenraad Hemker, Prof Mikhail Panteleev

This series, published in Thrombosis Journal, aims to bring together the latest information about global assays, to describe their action and to review their medical usefulness.

The standard assays currently used to assess the risk level of a patient suffering from thrombosis or bleeding, are not sensitive enough. Thrombosis can arise from a range of disorders affecting vessel walls, blood flow and blood composition, thus a simple "coagulability" will often fall short. It is therefore necessary to be able to assess the overall interaction; a global integral assay to assess hemostatic risks.

Global assays are an experimental, in vitro model of hemostasis/thrombosis that aim to mimic all aspects of the system.

Our hope in that this collection of reviews will increase knowledge of global assays and lead to their further development.

  1. Review

    Global assays and the management of oral anticoagulation

    Coagulation tests range from global or overall tests to assays specific to individual clotting factors and their inhibitors. Whether a particular test is influenced by an oral anticoagulant depends on the prin...

    Herm Jan M Brinkman

    Thrombosis Journal 2015 13:9

    Published on: 10 February 2015

  2. Review

    Assays of different aspects of haemostasis – what do they measure?

    Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibr...

    Nahreen Tynngård, Tomas L Lindahl and Sofia Ramström

    Thrombosis Journal 2015 13:8

    Published on: 5 February 2015

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