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Articles from the Drug Safety and Effectiveness Network (DSEN)

A thematic series published in Systematic Reviews.

The Canadian Institute of Health Research (CIHR), along with Health Canada and other stakeholders, established the DSEN to identify gaps in knowledge about drug effectiveness and safety. This series includes a number of articles from the network investigating a range of drugs used in various conditions, including heart disease and diabetes.

  1. Protocol

    Safety, effectiveness, and cost of long-acting versus intermediate-acting insulin for type 1 diabetes: Protocol for a systematic review and network meta-analysis

    Type 1 diabetes mellitus (T1DM) causes progressive destruction of pancreatic beta cells leading to absolute insulin deficiency. Treatment of T1DM requires insulin, and some evidence suggests that longer acting...

    Andrea C Tricco, Huda M Ashoor, Charlene Soobiah, Brenda Hemmelgarn, David Moher, Brian Hutton, Catherine H Yu, Sumit R Majumdar and Sharon E Straus

    Systematic Reviews 2013 2:73

    Published on: 10 September 2013

  2. Protocol

    Interventions to decrease the risk of adverse cardiac events for post-surgery or chemotherapy patients taking serotonin (5-HT3) receptor antagonists: protocol for a systematic review and network meta-analysis

    Patients undergoing surgery or chemotherapy often experience nausea and vomiting. To increase their quality of life and treatment satisfaction, antiemetic medication, such as serotonin receptor antagonists, is...

    Andrea C Tricco, Charlene Soobiah, Jesmin Antony, Brenda Hemmelgarn, David Moher, Brian Hutton and Sharon E Straus

    Systematic Reviews 2013 2:45

    Published on: 28 June 2013

  3. Protocol

    Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis

    Type 2 diabetes mellitus (T2DM) results from insulin resistance and relative insulin deficiency. T2DM treatment is a step-wise approach beginning with lifestyle modifications (for example, diet, exercise), fol...

    Andrea C Tricco, Jesmin Antony, Charlene Soobiah, Brenda Hemmelgarn, David Moher, Brian Hutton, Catherine H Yu, Sumit R Majumdar and Sharon E Straus

    Systematic Reviews 2013 2:47

    Published on: 28 June 2013

  4. Protocol

    Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis

    Serotonin (5-HT3) receptor antagonists are a class of antiemetic medications often used to prevent nausea and vomiting among patients undergoing chemotherapy, radiotherapy or surgery. However, recent studies s...

    Andrea C Tricco, Charlene Soobiah, Jesmin Antony, Brenda Hemmelgarn, David Moher, Brian Hutton and Sharon E Straus

    Systematic Reviews 2013 2:46

    Published on: 28 June 2013

  5. Protocol

    Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses

    Hypertension has been cited as the most common attributable risk factor for death worldwide, and in Canada more than one of every five adults had this diagnosis in 2007. In addition to different lifestyle modi...

    Brian Hutton, Jennifer Tetzlaff, Fatemeh Yazdi, Justin Thielman, Salmaan Kanji, Dean Fergusson, Lise Bjerre, Edward Mills, Kristian Thorlund, Andrea Tricco, Sharon Straus, David Moher and Frans HH Leenen

    Systematic Reviews 2013 2:44

    Published on: 28 June 2013

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