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  1. Review

    Protein function annotation by homology-based inference

    With many genomes now sequenced, computational annotation methods to characterize genes and proteins from their sequence are increasingly important. The BioSapiens Network has developed tools to address all st...

    Yaniv Loewenstein, Domenico Raimondo, Oliver C Redfern, James Watson, Dmitrij Frishman, Michal Linial, Christine Orengo, Janet Thornton and Anna Tramontano

    Genome Biology 2009 10:207

    Published on: 2 February 2009

  2. Review

    Sequence-based feature prediction and annotation of proteins

    A recent trend in computational methods for annotation of protein function is that many prediction tools are combined in complex workflows and pipelines to facilitate the analysis of feature combinations, for ...

    Agnieszka S Juncker, Lars J Jensen, Andrea Pierleoni, Andreas Bernsel, Michael L Tress, Peer Bork, Gunnar von Heijne, Alfonso Valencia, Christos A Ouzounis, Rita Casadio and Søren Brunak

    Genome Biology 2009 10:206

    Published on: 2 February 2009

  3. Review

    Integrating sequence, evolution and functional genomics in regulatory genomics

    With genome analysis expanding from the study of genes to the study of gene regulation, 'regulatory genomics' utilizes sequence information, evolution and functional genomics measurements to unravel how regula...

    Martin Vingron, Alvis Brazma, Richard Coulson, Jacques van Helden, Thomas Manke, Kimmo Palin, Olivier Sand and Esko Ukkonen

    Genome Biology 2009 10:202

    Published on: 30 January 2009

  4. Review

    Identifying protein-coding genes in genomic sequences

    The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequ...

    Jennifer Harrow, Alinda Nagy, Alexandre Reymond, Tyler Alioto, Laszlo Patthy, Stylianos E Antonarakis and Roderic Guigó

    Genome Biology 2009 10:201

    Published on: 30 January 2009