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Molecular Neurodegeneration: Basic biology and disease pathways

The field of neurodegeneration research has been advancing rapidly over the past few years, and has provided intriguing new insights into the normal physiological functions and pathogenic roles of a wide range of molecules associated with several devastating neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington’s disease, and Down syndrome. Recent developments have also facilitated initial efforts to translate preclinical discoveries toward novel therapeutic approaches and clinical trials in humans.

These recent developments are reviewed in this current Article Collection in a number of state-of-the-art manuscripts that cover themes presented at the Third International Conference on “Molecular Neurodegeneration: Basic biology and disease pathways” held in Cannes, France, September, 2013.

  1. Review

    Structural biology of presenilin 1 complexes

    The presenilin genes were first identified as the site of missense mutations causing early onset autosomal dominant familial Alzheimer's disease. Subsequent work has shown that the presenilin proteins are the ...

    Yi Li, Christopher Bohm, Roger Dodd, Fusheng Chen, Seema Qamar, Gerold Schmitt-Ulms, Paul E Fraser and Peter H St George-Hyslop

    Molecular Neurodegeneration 2014 9:59

    Published on: 18 December 2014

  2. Editorial

    Molecular neurodegeneration: basic biology and disease pathways

    The field of neurodegeneration research has been advancing rapidly over the past few years, and has provided intriguing new insights into the normal physiological functions and pathogenic roles of a wide range...

    Robert Vassar and Hui Zheng

    Molecular Neurodegeneration 2014 9:34

    Published on: 23 September 2014

  3. Review

    Dysregulation of protein trafficking in neurodegeneration

    Intracellular protein trafficking plays an important role in neuronal function and survival. Protein misfolding is a common theme found in many neurodegenerative diseases, and intracellular trafficking machine...

    Xin Wang, Timothy Huang, Guojun Bu and Huaxi Xu

    Molecular Neurodegeneration 2014 9:31

    Published on: 25 August 2014

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