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Antibiotic resistance in the ICU

Edited by: Professor Steven Opal

The progressive loss of antibiotic activity as a result of dissemination of antibacterial resistance genes is increasingly recognized as global threat to humankind. Critical Care is therefore introducing a series of papers that examine the problem of progressive antibiotic resistance in the ICU. These articles will focus on the mechanisms of resistance, spread of antibiotic resistance genes, efforts to limit the further spread of MDR pathogens, and novel current and future therapeutic approaches to respond to the challenge of antibiotic resistance. We hope that this thematic series will inform the clinician about steps that we can take to confront the threat of antibiotic resistance.

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Series Editor, with final decisions made by the Editor in Chief. The Series Editor and Editor in Chief declare no competing interests.

  1. Review

    Selective decontamination and antibiotic resistance in ICUs

    Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) have been associated with reduced mortality and lower ICU-acquired bacteremia and ventilator-associated pneumonia rat...

    Nienke L. Plantinga and Marc JM Bonten

    Critical Care 2015 19:259

    Published on: 24 June 2015

  2. Review

    Antibiotic stewardship in the intensive care unit

    The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs worldwide constitute a problem of crisis dimensions. The root causes of this problem are multifactorial, but the core iss...

    Charles-Edouard Luyt, Nicolas Bréchot, Jean-Louis Trouillet and Jean Chastre

    Critical Care 2014 18:480

    Published on: 13 August 2014

  3. Review

    The future of antibiotics

    Antibiotic resistance continues to spread even as society is experiencing a market failure of new antibiotic research and development (R&D). Scientific, economic, and regulatory barriers all contribute to the ...

    Brad Spellberg

    Critical Care 2014 18:228

    Published on: 27 June 2014

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