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The actinin family proteins: biological function and clinical implications

Guest edited by Dr Hung-Ying Kao

This collection of reviews from Cell & Bioscience explores the alpha actinin (ACTN) family proteins; actin-binding proteins that regulate cytokinesis, cell adhesion, spreading, migration and signaling to control cell function. Recent studies have revealed the potential of ACTN4 as a biomarker for metastatic cancers and the associations of genetic disorders and athletic performance with mutations in ACTN genes. These findings highlight the physiological significance of the ACTN protein family. This review series provides evolutionary aspects and biochemical characteristics of ACTN proteins and features related clinical implications of basic research.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editor declares no competing interests.

View all collections published in Cell & Bioscience.

  1. Review

    The role of alpha-actinin-4 in human kidney disease

    Mutations in the Alpha-actinin-4 gene (ACTN4) cause a rare form of familial focal segmental glomerulosclerosis in humans. Individuals with kidney disease-associated ACTN4 mutations tend to have mild to moderat...

    Di Feng, Clark DuMontier and Martin R Pollak

    Cell & Bioscience 2015 5:44

    Published on: 18 August 2015

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