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11 result(s) for 'author#Sara Hägg' within BMC
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Citation: Human Genomics 2018 12(Suppl 1):9
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Relative deprivation and mortality – a longitudinal study in a Swedish population of 4,7 million, 1990–2006
Relative deprivation has previously been discussed as a possible mechanism underlying the income-health relation. The idea is that income matters to the individual’s health, over and above the increased comman...
Citation: BMC Public Health 2012 12:664 -
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy
Statins are lipid-lowering drugs and starting treatment has been associated with DNA methylation changes at genes related to lipid metabolism. However, the longitudinal pattern of how statins affect DNA methyl...
Citation: Clinical Epigenetics 2022 14:153 -
DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-qu...
Citation: Clinical Epigenetics 2020 12:49 -
Dementia and psychotropic medications are associated with significantly higher mortality in geriatric patients hospitalized with COVID-19: data from the StockholmGeroCovid project
Dementia and psychotropic medications are discussed as risk factors for severe/lethal outcome of the coronavirus disease 2019 (COVID-19). We aimed to explore the associations between the presence of dementia a...
Citation: Alzheimer's Research & Therapy 2023 15:5 -
The epigenetic etiology of cardiovascular disease in a longitudinal Swedish twin study
Studies on DNA methylation have the potential to discover mechanisms of cardiovascular disease (CVD) risk. However, the role of DNA methylation in CVD etiology remains unclear.
Citation: Clinical Epigenetics 2021 13:129 -
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life
Epigenetic mechanisms are important in aging and may be involved in late-life changes in cognitive abilities. We conducted an epigenome-wide association study of leukocyte DNA methylation in relation to level ...
Citation: Clinical Epigenetics 2021 13:85 -
Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?
Frailty has been identified as a risk factor for cognitive impairment and dementia. However, it is not known whether familial factors, such as genetics and shared environmental factors, underlie this associati...
Citation: BMC Medicine 2021 19:248 -
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation i...
Citation: Genome Biology 2021 22:194 -
Comprehensive longitudinal study of epigenetic mutations in aging
The role of DNA methylation in aging has been widely studied. However, epigenetic mutations, here defined as aberrant methylation levels compared to the distribution in a population, are less understood. Hence...
Citation: Clinical Epigenetics 2019 11:187 -
The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study
Frailty index (FI) is a well-established predictor of all-cause mortality, but less is known for cause-specific mortality and whether familial effects influence the associations. Middle-aged individuals are al...
Citation: BMC Medicine 2019 17:94