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25 result(s) for 'author#Michael W. Lawlor' within BMC
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Citation: Journal for ImmunoTherapy of Cancer 2019 7(Suppl 1):283
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33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)
Citation: Journal for ImmunoTherapy of Cancer 2018 6(Suppl 1):115 -
SCTS Annual Meeting 2022 Abstracts
Citation: Journal of Cardiothoracic Surgery 2023 18(Suppl 1):198 -
Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials
Citation: Trials 2017 18(Suppl 1):200 -
Selected Abstracts from Artery 22
Citation: Artery Research 2023 29(Suppl 1):28 -
Ageing and Urbanization: Can Cities be Designed to Foster Active Ageing?
The world is currently experiencing two major demographic transitions: the ageing of populations, particularly in low and middle income countries, and urbanization. This paper briefly summarizes current theori...
Citation: Public Health Reviews 2010 32:BF03391610 -
Gait speed, cognition and falls in people living with mild-to-moderate Alzheimer disease: data from NILVAD
Previous evidence suggests that slower gait speed is longitudinally associated with cognitive impairment, dementia and falls in older adults. Despite this, the longitudinal relationship between gait speed, cog...
Citation: BMC Geriatrics 2020 20:117 -
Meeting Abstracts from the 70th Annual British Thyroid Association Meeting
Citation: Thyroid Research 2022 15(Suppl 1):11 -
Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb
Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden. Most NEB-NM patients have autosomal re...
Citation: Acta Neuropathologica Communications 2020 8:18 -
Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy
Nemaline myopathy (NM) is a congenital muscle disease associated with weakness and the presence of nemaline bodies (rods) in muscle fibers. Mutations in seven genes have been associated with NM, but the most c...
Citation: Skeletal Muscle 2011 1:23 -
Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study
Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothe...
Citation: Critical Care 2019 23:235 -
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Ne...
Citation: Biological Research 2023 56:46 -
Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringi...
Citation: Skeletal Muscle 2020 10:34 -
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs). We inv...
Citation: BMC Medicine 2022 20:210 -
ROR1 and ROR2 expression in pancreatic cancer
The Wnt receptors ROR1 and ROR2 are generating increased interest as cancer therapeutic targets but remain understudied in pancreatic ductal adenocarcinoma (PDAC). Compared to canonical Wnt/ β-catenin signalli...
Citation: BMC Cancer 2021 21:1199 -
Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and ...
Citation: Respiratory Research 2010 11:29 -
Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model
Duchenne muscular dystrophy (DMD) associated cardiomyopathy is a major cause of morbidity and mortality. In an in vitro DMD cardiomyocyte model, nicorandil reversed stress-induced cell injury through multiple ...
Citation: BMC Cardiovascular Disorders 2021 21:302 -
rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy
X-linked myotubular myopathy (XLMTM) is a life-threatening skeletal muscle disease caused by mutations in the MTM1 gene. XLMTM fibres display a population of nuclei mispositioned in the centre. In the present stu...
Citation: Acta Neuropathologica Communications 2020 8:167 -
Detecting type 2 diabetes and prediabetes among asymptomatic adults in the United States: modeling American Diabetes Association versus US Preventive Services Task Force diabetes screening guidelines
Screening to detect prediabetes and diabetes enables early prevention and intervention. This study describes the number and characteristics of asymptomatic, undiagnosed adults in the United States who could be...
Citation: Population Health Metrics 2014 12:12 -
Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination
Over recent years, human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have been associated with monophasic and relapsing central nervous system demyelination involving the optic nerves...
Citation: Acta Neuropathologica Communications 2019 7:145