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14 result(s) for 'author#Kjeld Schmiegelow' within BMC

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  1. A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-lo...

    Authors: Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty…
    Citation: BMC Cancer 2022 22:483
    Content type: Study protocol Published on:

  2. We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was ...

    Authors: Jessica Nordlund, Christofer L Bäcklin, Vasilios Zachariadis, Lucia Cavelier, Johan Dahlberg, Ingegerd Öfverholm, Gisela Barbany, Ann Nordgren, Elin Övernäs, Jonas Abrahamsson, Trond Flaegstad, Mats M Heyman, Ólafur G Jónsson, Jukka Kanerva, Rolf Larsson, Josefine Palle…
    Citation: Clinical Epigenetics 2015 7:11
    Content type: Research Published on:

  3. Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal. Not least within oncology, where many pa...

    Authors: Jacob Nersting, Louise Borst and Kjeld Schmiegelow
    Citation: Clinical Proteomics 2011 8:8
    Content type: Review Published on:

  4. Children with cancer experience impaired cardiorespiratory fitness and physical function during and after treatment restricting their possibilities to engage in social activities including sport, leisure activ...

    Authors: Martin Kaj Fridh Nielsen, Jesper Frank Christensen, Thomas Leth Frandsen, Troels Thorsteinsson, Lars Bo Andersen, Karl Bang Christensen, Peder Skov Wehner, Henrik Hasle, Lis Ørgaard Adamsen, Kjeld Schmiegelow and Hanne Bækgaard Larsen
    Citation: BMC Medicine 2020 18:175
    Content type: Research article Published on:

  5. Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterat...

    Authors: Magnus Borssén, Jessica Nordlund, Zahra Haider, Mattias Landfors, Pär Larsson, Jukka Kanerva, Kjeld Schmiegelow, Trond Flaegstad, Ólafur Gísli Jónsson, Britt-Marie Frost, Josefine Palle, Erik Forestier, Mats Heyman, Magnus Hultdin, Gudmar Lönnerholm and Sofie Degerman
    Citation: Clinical Epigenetics 2018 10:31
    Content type: Short report Published on:

  6. Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on...

    Authors: Jessica Nordlund, Christofer L Bäcklin, Per Wahlberg, Stephan Busche, Eva C Berglund, Maija-Leena Eloranta, Trond Flaegstad, Erik Forestier, Britt-Marie Frost, Arja Harila-Saari, Mats Heyman, Ólafur G Jónsson, Rolf Larsson, Josefine Palle, Lars Rönnblom, Kjeld Schmiegelow…
    Citation: Genome Biology 2013 14:r105
    Content type: Research Published on:

  7. Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of poste...

    Authors: Morten Wibroe, Johan Cappelen, Charlotte Castor, Niels Clausen, Pernilla Grillner, Thora Gudrunardottir, Ramneek Gupta, Bengt Gustavsson, Mats Heyman, Stefan Holm, Atte Karppinen, Camilla Klausen, Tuula Lönnqvist, René Mathiasen, Pelle Nilsson, Karsten Nysom…
    Citation: BMC Cancer 2017 17:439
    Content type: Study protocol Published on:

  8. Ependymoma is the second most common malignant brain tumor in children. The etiology is largely unknown and germline DNA sequencing studies focusing on childhood ependymoma are limited. We therefore performed ...

    Authors: Jon Foss-Skiftesvik, Ulrik Kristoffer Stoltze, Thomas van Overeem Hansen, Lise Barlebo Ahlborn, Erik Sørensen, Sisse Rye Ostrowski, Solvej Margrete Aldringer Kullegaard, Adrian Otamendi Laspiur, Linea Cecilie Melchior, David Scheie, Bjarne Winther Kristensen, Jane Skjøth-Rasmussen, Kjeld Schmiegelow, Karin Wadt and René Mathiasen
    Citation: Acta Neuropathologica Communications 2022 10:123
    Content type: Research Published on:

  9. Next-generation sequencing (NGS) based population screening holds great promise for disease prevention and earlier diagnosis, but the costs associated with screening millions of humans remain prohibitive. New ...

    Authors: Ulrik Kristoffer Stoltze, Christian Munch Hagen, Thomas van Overeem Hansen, Anna Byrjalsen, Anne-Marie Gerdes, Victor Yakimov, Simon Rasmussen, Marie Bækvad-Hansen, David Michael Hougaard, Kjeld Schmiegelow, Henrik Hjalgrim, Karin Wadt and Jonas Bybjerg-Grauholm
    Citation: Genome Medicine 2023 15:17
    Content type: Research Published on:

  10. Interprofessional education in childhood cancer is a multifaceted field involving multiple healthcare professionals with general and specialised knowledge and skills. Complex treatment, care and rehabilitation...

    Authors: Martha Krogh Topperzer, Marianne Hoffmann, Hanne Bækgaard Larsen, Susanne Rosthøj, Jacob Nersting, Louise Ingerslev Roug, Peter Pontoppidan, Liv Andrés-Jensen, Birgitte Lausen, Kjeld Schmiegelow and Jette Led Sørensen
    Citation: BMC Health Services Research 2020 20:1124
    Content type: Study protocol Published on:

  11. Early diagnosis is crucial for the treatment of childhood cancer as it in some cases can prevent progression of disease and improve prognoses. However, childhood cancer can be difficult to diagnose and barrier...

    Authors: Line Hjøllund Pedersen, Ayo Wahlberg, Marie Cordt, Kjeld Schmiegelow, Susanne Oksbjerg Dalton and Hanne Bækgaard Larsen
    Citation: BMC Health Services Research 2020 20:969
    Content type: Research article Published on:

  12. While underlying mechanisms and pathways of social inequalities in cancer survival have been extensively examined in adults, this is less so for children with cancer. Hypothesized mechanisms include prediagnos...

    Authors: Line Hjøllund Pedersen, Friederike Erdmann, Gitte Lerche Aalborg, Lisa Lyngsie Hjalgrim, Hanne Bækgaard Larsen, Kjeld Schmiegelow, Jeanette Falck Winther and Susanne Oksbjerg Dalton
    Citation: BMC Cancer 2021 21:1104
    Content type: Research Published on:

  13. During cancer treatment children have reduced contact with their social network of friends, and have limited participation in education, sports, and leisure activities. During and following cancer treatment, c...

    Authors: Troels Thorsteinsson, Anne Sofie Helms, Lis Adamsen, Lars Bo Andersen, Karen Vitting Andersen, Karl Bang Christensen, Henrik Hasle, Carsten Heilmann, Nete Hejgaard, Christoffer Johansen, Marianne Madsen, Svend Aage Madsen, Venka Simovska, Birgit Strange, Lone Friis Thing, Peder Skov Wehner…
    Citation: BMC Cancer 2013 13:544
    Content type: Study protocol Published on:

  14. Methotrexate (MTX) eradicates leukemic cells by disrupting de novo nucleotide biosynthesis and DNA replication, resulting in cell death. Since its introduction in 1947, MTX-containing chemotherapeutic regimens...

    Authors: Anna Wojtuszkiewicz, Godefridus J. Peters, Nicole L. van Woerden, Boas Dubbelman, Gabriele Escherich, Kjeld Schmiegelow, Edwin Sonneveld, Rob Pieters, Peter M. van de Ven, Gerrit Jansen, Yehuda G. Assaraf, Gertjan J. L. Kaspers and Jacqueline Cloos
    Citation: Journal of Hematology & Oncology 2015 8:61
    Content type: Research Article Published on: