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45 result(s) for 'author#Kevin C Kain' within BMC

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  1. Primary Objective: To determine if pre-exposure prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily reduces microbiologically confirmed COVID-19 among front line health care workers at...

    Authors: Julie K. Wright, Darrell H. S. Tan, Sharon L. Walmsley, Jennifer Hulme, Erin O’Connor, Carolyn Snider, Ivy Cheng, Adrienne K. Chan, Bjug Borgundvaag, Shelley McLeod, Michael H. Gollob, Rosemarie J. Clarke, Linda Dresser, Fatima Haji, Tony Mazzulli, Samira Mubareka…
    Citation: Trials 2020 21:647
    Content type: Letter Published on:

  3. Cerebral malaria (CM) Is associated with excessive Inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, infl...

    Authors: Constance A M Finney, Cheryl A Hawkes, Dylan C Kain, Aggrey Dhabangi, Charles Musoke, Christine Cserti-Gazdewich, Tamas Oravecz, W Conrad Liles and Kevin C Kain
    Citation: Molecular Medicine 2011 17:1707717
    Content type: Research Article Published on:

  4. Severe falciparum malaria (SM) pathogenesis has been attributed, in part, to deleterious systemic host inflammatory responses to infection. High mobility group box 1 (HMGB1) protein is an important mediator of...

    Authors: Sarah J Higgins, Katharine Xing, Hani Kim, Dylan C Kain, Feng Wang, Aggrey Dhabangi, Charles Musoke, Christine M Cserti-Gazdewich, Kevin J Tracey, Kevin C Kain and W Conrad Liles
    Citation: Malaria Journal 2013 12:105
    Content type: Research Published on:

  5. Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant acti...

    Authors: Hani Kim, Ilyse Darwish, Maria-Fernanda Monroy, Darwin J Prockop, W Conrad Liles and Kevin C Kain
    Citation: BMC Immunology 2014 15:1
    Content type: Research article Published on:

  6. Despite potent anti-malarial treatment, mortality rates associated with severe falciparum malaria remain high. To attempt to improve outcome, several trials have assessed a variety of potential adjunctive ther...

    Authors: Rosauro Varo, Clara Erice, Sydney Johnson, Quique Bassat and Kevin C. Kain
    Citation: Malaria Journal 2020 19:268
    Content type: Opinion Published on:

  7. Although Fas (CD95) is recognized as a death receptor that induces apoptosis, recent studies indicate that the Fas/FasL system can induce pro-inflammatory cytokine production by macrophages independent of conv...

    Authors: Feng Wang, Ziyue Lu, Michael Hawkes, Huan Yang, Kevin C Kain and W Conrad Liles
    Citation: Journal of Inflammation 2010 7:30
    Content type: Research Published on:

  8. Febrile symptoms in children are a leading cause of health-care seeking behaviour worldwide. The majority of febrile illnesses are uncomplicated and self-limited, without the need for referral or hospital admi...

    Authors: Chloe R. McDonald, Andrea Weckman, Melissa Richard-Greenblatt, Aleksandra Leligdowicz and Kevin C. Kain
    Citation: Malaria Journal 2018 17:353
    Content type: Opinion Published on:

  9. Severe malaria remains a major cause of global morbidity and mortality. Despite the use of potent anti-parasitic agents, the mortality rate in severe malaria remains high. Adjunctive therapies that target the ...

    Authors: Michael Hawkes, Robert O Opoka, Sophie Namasopo, Christopher Miller, Kevin E Thorpe, James V Lavery, Andrea L Conroy, W Conrad Liles, Chandy C John and Kevin C Kain
    Citation: Trials 2011 12:176
    Content type: Study protocol Published on:

  10. Malaria is associated with haemolysis and the release of plasma haem. Plasma haem can cause endothelial injury and organ dysfunction, and is normally scavenged by haemopexin to limit toxicity. It was hypothes...

    Authors: Robyn E. Elphinstone, Frank Riley, Tian Lin, Sarah Higgins, Aggrey Dhabangi, Charles Musoke, Christine Cserti-Gazdewich, Raymond F. Regan, H. Shaw Warren and Kevin C. Kain
    Citation: Malaria Journal 2015 14:511
    Content type: Research Published on:

  11. miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may co...

    Authors: Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles and Kevin C. Kain
    Citation: Molecular Medicine 2017 23:2301024
    Content type: Research Article Published on:

  12. Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa. The pathogenesis and prognostic significance of BWF and AKI are not we...

    Authors: Andrea L. Conroy, Michael T. Hawkes, Aleksandra Leligdowicz, Ivan Mufumba, Michelle C. Starr, Kathleen Zhong, Sophie Namasopo, Chandy C. John, Robert O. Opoka and Kevin C. Kain
    Citation: BMC Medicine 2022 20:221
    Content type: Research article Published on:

  13. Despite the widespread use and availability of rapidly acting anti-malarials, the fatality rate of severe malaria in sub-Saharan Africa remains high. Adjunctive therapies that target the host response to malar...

    Authors: Rosauro Varo, Valerie M. Crowley, Antonio Sitoe, Lola Madrid, Lena Serghides, Rubao Bila, Helio Mucavele, Alfredo Mayor, Quique Bassat and Kevin C. Kain
    Citation: Malaria Journal 2017 16:215
    Content type: Research Published on:

  14. Inappropriate antibiotics use in lower respiratory tract infections (LRTI) is a major contributor to resistance. We aimed to design an algorithm based on clinical signs and host biomarkers to identify bacteria...

    Authors: Sarika K. L. Hogendoorn, Loïc Lhopitallier, Melissa Richard-Greenblatt, Estelle Tenisch, Zainab Mbarack, Josephine Samaka, Tarsis Mlaganile, Aline Mamin, Blaise Genton, Laurent Kaiser, Valérie D’Acremont, Kevin C. Kain and Noémie Boillat-Blanco
    Citation: BMC Infectious Diseases 2022 22:39
    Content type: Research Published on:

  15. Severe malaria remains a major cause of childhood mortality globally. Decreased endothelial nitric oxide is associated with severe and fatal malaria. The hypothesis was that adjunctive inhaled nitric oxide (iN...

    Authors: Michael T. Hawkes, Andrea L. Conroy, Robert O. Opoka, Laura Hermann, Kevin E. Thorpe, Chloe McDonald, Hani Kim, Sarah Higgins, Sophie Namasopo, Chandy John, Chris Miller, W. Conrad Liles and Kevin C. Kain
    Citation: Malaria Journal 2015 14:421
    Content type: Research Published on:

  16. Members of the CD36 scavenger receptor family have been implicated as sensors of microbial products that mediate phagocytosis and inflammation in response to a broad range of pathogens. We investigated the rol...

    Authors: Michael Hawkes, Xiaoming Li, Maryanne Crockett, Angelina Diassiti, Constance Finney, Gundula Min-Oo, W Conrad Liles, Jun Liu and Kevin C Kain
    Citation: BMC Infectious Diseases 2010 10:299
    Content type: Research article Published on:

  17. Severe and fatal malaria are associated with dysregulated host inflammatory responses to infection. Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein implicated in regulating immune responses. Expression ...

    Authors: Laura K Erdman, Carlene Petes, Ziyue Lu, Aggrey Dhabangi, Charles Musoke, Christine M Cserti-Gazdewich, Chun Geun Lee, Wayne Conrad Liles, Jack A Elias and Kevin C Kain
    Citation: Malaria Journal 2014 13:279
    Content type: Research Published on:

  18. Malaria is a major cause of morbidity and mortality in sub-Saharan Africa, and poor outcomes have been associated with endothelial activation. In this study, biomarkers of endothelial activation, haemostasis, ...

    Authors: Susan M. Graham, Junmei Chen, Dominic W. Chung, Kevin R. Barker, Andrea L. Conroy, Michael T. Hawkes, Sophie Namasopo, Kevin C. Kain, José A. López and W. Conrad Liles
    Citation: Malaria Journal 2016 15:56
    Content type: Research Published on:

  19. The development and outcome of cerebral malaria (CM) reflects a complex interplay between parasite-expressed virulence factors and host response to infection. The murine CM model, Plasmodium berghei ANKA (PbA), w...

    Authors: Fiona E Lovegrove, Lourdes Peña-Castillo, Naveed Mohammad, W Conrad Liles, Timothy R Hughes and Kevin C Kain
    Citation: BMC Genomics 2006 7:295
    Content type: Research article Published on:

  20. Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity. The aim of this study was...

    Authors: Andrea L Conroy, Erin I Lafferty, Fiona E Lovegrove, Srivicha Krudsood, Noppadon Tangpukdee, W Conrad Liles and Kevin C Kain
    Citation: Malaria Journal 2009 8:295
    Content type: Research Published on: