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17 result(s) for 'author#Jan H. Veldink' within BMC

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  1. DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identify 818 genes that affect DNA methylati...

    Authors: Paul J. Hop, René Luijk, Lucia Daxinger, Maarten van Iterson, Koen F. Dekkers, Rick Jansen, Joyce B. J. van Meurs, Peter A. C. ’t Hoen, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Dorret I. Boomsma, P. Eline Slagboom, Jan H. Veldink, Erik W. van Zwet and Bastiaan T. Heijmans
    Citation: Genome Biology 2020 21:220
    Content type: Research Published on:

  2. Authors: Sterre C. M. de Boer, Lauren Woolley, Merel O. Mol, Maria Serpente, Lianne M. Reus, Rick van Minkelen, Joke F. A. van Vugt, Federica Sorrentino, Jan H. Veldink, Harro Seelaar, Daniela Galimberti, Fred van Ruissen, Simon Mead, Ekaterina Rogaeva, Yolande A. L. Pijnenburg and Sven J. van der Lee
    Citation: Acta Neuropathologica Communications 2022 10:141
    Content type: Letter to the Editor Published on:

    The Letter to the Editor to this article has been published in Acta Neuropathologica Communications 2022 10:173

    The original article was published in Acta Neuropathologica Communications 2020 8:187

  3. Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methyl...

    Authors: Koen F. Dekkers, Maarten van Iterson, Roderick C. Slieker, Matthijs H. Moed, Marc Jan Bonder, Michiel van Galen, Hailiang Mei, Daria V. Zhernakova, Leonard H. van den Berg, Joris Deelen, Jenny van Dongen, Diana van Heemst, Albert Hofman, Jouke J. Hottenga, Carla J. H. van der Kallen, Casper G. Schalkwijk…
    Citation: Genome Biology 2016 17:138
    Content type: Research Published on:

  4. Chromosome 17q21.31 contains a common inversion polymorphism of approximately 900 kb in populations with European ancestry. Two divergent MAPT haplotypes, H1 and H2 are described with distinct linkage disequilibr...

    Authors: Simone de Jong, Iouri Chepelev, Esther Janson, Eric Strengman, Leonard H van den Berg, Jan H Veldink and Roel A Ophoff
    Citation: BMC Genomics 2012 13:458
    Content type: Research article Published on:

  5. Aging is a multifactorial process that affects multiple tissues and is characterized by changes in homeostasis over time, leading to increased morbidity. Whole blood gene expression signatures have been associ...

    Authors: Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra and Lude Franke
    Citation: BMC Genomics 2021 22:184
    Content type: Research article Published on:

  6. Repeat expansions are responsible for over 40 monogenic disorders, and undoubtedly more pathogenic repeat expansions remain to be discovered. Existing methods for detecting repeat expansions in short-read sequ...

    Authors: Egor Dolzhenko, Mark F. Bennett, Phillip A. Richmond, Brett Trost, Sai Chen, Joke J. F. A. van Vugt, Charlotte Nguyen, Giuseppe Narzisi, Vladimir G. Gainullin, Andrew M. Gross, Bryan R. Lajoie, Ryan J. Taft, Wyeth W. Wasserman, Stephen W. Scherer, Jan H. Veldink, David R. Bentley…
    Citation: Genome Biology 2020 21:102
    Content type: Method Published on:

  7. The predominant model for regulation of gene expression through DNA methylation is an inverse association in which increased methylation results in decreased gene expression levels. However, recent studies sug...

    Authors: Kristel R van Eijk, Simone de Jong, Marco PM Boks, Terry Langeveld, Fabrice Colas, Jan H Veldink, Carolien GF de Kovel, Esther Janson, Eric Strengman, Peter Langfelder, René S Kahn, Leonard H van den Berg, Steve Horvath and Roel A Ophoff
    Citation: BMC Genomics 2012 13:636
    Content type: Research article Published on:

  8. Amyotrophic Lateral Sclerosis (ALS) is a lethal disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Diagnosis is mainly based on clinical symptoms, and there is cu...

    Authors: Christiaan GJ Saris, Steve Horvath, Paul WJ van Vught, Michael A van Es, Hylke M Blauw, Tova F Fuller, Peter Langfelder, Joseph DeYoung, John HJ Wokke, Jan H Veldink, Leonard H van den Berg and Roel A Ophoff
    Citation: BMC Genomics 2009 10:405
    Content type: Research article Published on:

  9. Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to disease liability. Genome-wide association studies (GWAS) have identified ten risk loci to...

    Authors: Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe…
    Citation: Genome Medicine 2022 14:7
    Content type: Research Published on:

  10. Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathoge...

    Authors: Catarina Salgado, Nelleke Gruis, Bastiaan T. Heijmans, Jan Oosting and Remco van Doorn
    Citation: Clinical Epigenetics 2020 12:43
    Content type: Short report Published on:

  11. People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm...

    Authors: Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva…
    Citation: Genome Biology 2021 22:90
    Content type: Research Published on:

  12. Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG dinucleotides to accurately predict individual chronological age. A popular application of these clocks is to explore whether the dev...

    Authors: Thomas H. Jonkman, Koen F. Dekkers, Roderick C. Slieker, Crystal D. Grant, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Lude Franke, Jan H. Veldink, Dorret I. Boomsma, P. Eline Slagboom, B. I. O. S. Consortium and Bastiaan T. Heijmans
    Citation: Genome Biology 2022 23:24
    Content type: Research Published on:

  13. Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation change...

    Authors: Roderick C. Slieker, Maarten van Iterson, René Luijk, Marian Beekman, Daria V. Zhernakova, Matthijs H. Moed, Hailiang Mei, Michiel van Galen, Patrick Deelen, Marc Jan Bonder, Alexandra Zhernakova, André G. Uitterlinden, Ettje F. Tigchelaar, Coen D. A. Stehouwer, Casper G. Schalkwijk, Carla J. H. van der Kallen…
    Citation: Genome Biology 2016 17:191
    Content type: Research Published on:

  14. Worldwide, the prevalence of obesity and insulin resistance has grown dramatically. Gene expression profiling in blood represents a powerful means to explore disease pathogenesis, but the potential impact of i...

    Authors: Marianthi Kalafati, Martina Kutmon, Chris T. Evelo, Carla J. H. van der Kallen, Casper G. Schalkwijk, Coen D. A. Stehouwer, B. I. O. S. Consortium, Ellen E. Blaak, Marleen M. J. van Greevenbroek and Michiel Adriaens
    Citation: Genes & Nutrition 2021 16:22
    Content type: Research Published on:

  15. The genetic underpinning of sexual dimorphism is very poorly understood. The prevalence of many diseases differs between men and women, which could be in part caused by sex-specific genetic effects. Neverthele...

    Authors: Eleonora Porcu, Annique Claringbould, Antoine Weihs, Kaido Lepik, Tom G. Richardson, Uwe Völker, Federico A. Santoni, Alexander Teumer, Lude Franke, Alexandre Reymond and Zoltán Kutalik
    Citation: Genome Medicine 2022 14:89
    Content type: Research Published on:

  16. Population-scale expression profiling studies can provide valuable insights into biological and disease-underlying mechanisms. The availability of phenotypic traits is essential for studying clinical effects. ...

    Authors: Anna Niehues, Daniele Bizzarri, Marcel J.T. Reinders, P. Eline Slagboom, Alain J. van Gool, Erik B. van den Akker and Peter A.C. ’t Hoen
    Citation: BMC Genomics 2022 23:546
    Content type: Research Published on:

  17. We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if le...

    Authors: Maarten van Iterson, Erik W. van Zwet and Bastiaan T. Heijmans
    Citation: Genome Biology 2017 18:19
    Content type: METHOD Published on: