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15 result(s) for 'author#Hiroyuki Aburatani' within BMC

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  2. Hepatocyte nuclear factor-4α (HNF4α; NR2A1) is an orphan member of the nuclear receptor superfamily involved in various processes that could influence endoderm development, glucose and lipid metabolism. A loss...

    Authors: Shuying Jiang, Toshiya Tanaka, Hiroko Iwanari, Hiromitsu Hotta, Hisahiko Yamashita, Junko Kumakura, Yuichiro Watanabe, Yasutoshi Uchiyama, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko Kodama and Makoto Naito
    Citation: Nuclear Receptor 2003 1:5
    Content type: Research Published on:

  3. Pseudomyxoma peritonei is a rare disease condition mainly caused by primary mucinous tumors from the appendix and rarely from the ovary, such as when mucinous ovarian tumors arise from within a teratoma. Molec...

    Authors: Ayumi Taguchi, Hirofumi Rokutan, Katsutoshi Oda, Michihiro Tanikawa, Saki Tanimoto, Kenbun Sone, Mayuyo Mori, Tetsushi Tsuruga, Shinji Kohsaka, Kenji Tatsuno, Aya Shinozaki-Ushiku, Kiyoshi Miyagawa, Hiroyuki Mano, Hiroyuki Aburatani, Tetsuo Ushiku and Yutaka Osuga
    Citation: BMC Medical Genomics 2022 15:51
    Content type: Case report Published on:

  4. The changes in the liver in nonalcoholic fatty liver disease (NAFLD) range over a wide spectrum, extending from steatosis to steatohepatitis (NASH). However it has remained difficult to differentiate between N...

    Authors: Masato Yoneda, Takashi Uchiyama, Shingo Kato, Hiroki Endo, Koji Fujita, Kyoko Yoneda, Hironori Mawatari, Hiroshi Iida, Hirokazu Takahashi, Hiroyuki Kirikoshi, Masahiko Inamori, Yuichi Nozaki, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Shiro Maeyama…
    Citation: BMC Gastroenterology 2008 8:53
    Content type: Research article Published on:

  5. Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets f...

    Authors: Shingo Tsuji, Takeshi Hase, Ayako Yachie-Kinoshita, Taiko Nishino, Samik Ghosh, Masataka Kikuchi, Kazuro Shimokawa, Hiroyuki Aburatani, Hiroaki Kitano and Hiroshi Tanaka
    Citation: Alzheimer's Research & Therapy 2021 13:92
    Content type: Research Published on:

  6. DNA copy number alterations are one of the main characteristics of the cancer cell karyotype and can contribute to the complex phenotype of these cells. These alterations can lead to gains in cellular oncogene...

    Authors: Jing Huang, Wen Wei, Joyce Chen, Jane Zhang, Guoying Liu, Xiaojun Di, Rui Mei, Shumpei Ishikawa, Hiroyuki Aburatani, Keith W Jones and Michael H Shapero
    Citation: BMC Bioinformatics 2006 7:83
    Content type: Methodology article Published on:

  7. In the functional genomics analysis domain, various methodologies are available for interpreting the results produced by high-throughput biological experiments. These methods commonly use a list of genes as an...

    Authors: Shingo Tsuji, Sigeo Ihara and Hiroyuki Aburatani
    Citation: BMC Systems Biology 2012 6:124
    Content type: Methodology article Published on:

  8. Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. T...

    Authors: Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki, Genta Nagae, Yuki Katou, Shuichi Tsutsumi, Natsu Nakajima, Hiroshi Fukuhara, Atsushi Iguchi, Takahide Kohro, Yasuharu Kanki, Yutaka Saito, Mika Kobayashi, Akashi Izumi-Taguchi, Naoki Osato, Kenji Tatsuno…
    Citation: Epigenetics & Chromatin 2019 12:77
    Content type: Research Published on:

  9. Synergistic transcriptional activation by different stimuli has been reported along with a diverse array of mechanisms, but the full scope of these mechanisms has yet to be elucidated.

    Authors: Tsuyoshi Inoue, Takahide Kohro, Toshiya Tanaka, Yasuharu Kanki, Guoliang Li, Huay-Mei Poh, Imari Mimura, Mika Kobayashi, Akashi Taguchi, Takashi Maejima, Jun-ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Hirofumi Aruga, Shoulian Dong, Junko F Stevens…
    Citation: Genome Biology 2014 15:R63
    Content type: Research Published on:

  10. Microarray technology has unveiled transcriptomic differences among tumors of various phenotypes, and, especially, brought great progress in molecular understanding of phenotypic diversity of breast tumors. Ho...

    Authors: Atsushi Niida, Andrew D Smith, Seiya Imoto, Shuichi Tsutsumi, Hiroyuki Aburatani, Michael Q Zhang and Tetsu Akiyama
    Citation: BMC Bioinformatics 2008 9:404
    Content type: Research article Published on:

  11. Although microarray-based studies have revealed global view of gene expression in cancer cells, we still have little knowledge about regulatory mechanisms underlying the transcriptome. Several computational me...

    Authors: Atsushi Niida, Andrew D Smith, Seiya Imoto, Hiroyuki Aburatani, Michael Q Zhang and Tetsu Akiyama
    Citation: BMC Bioinformatics 2009 10:71
    Content type: Research article Published on:

  12. Single-cell RNA sequencing is fast becoming one the standard method for gene expression measurement, providing unique insights into cellular processes. A number of methods, based on general dimensionality redu...

    Authors: David A. duVerle, Sohiya Yotsukura, Seitaro Nomura, Hiroyuki Aburatani and Koji Tsuda
    Citation: BMC Bioinformatics 2016 17:363
    Content type: Software Published on:

  13. Among diffuse gliomas, oligodendrogliomas show relatively better prognosis, respond well to radiotherapy and chemotherapy, and seldom progress to very aggressive tumors. To elucidate the genetic and epigenetic...

    Authors: Koki Aihara, Akitake Mukasa, Genta Nagae, Masashi Nomura, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Junji Shibahara, Miwako Takahashi, Toshimitsu Momose, Shota Tanaka, Shunsaku Takayanagi, Shunsuke Yanagisawa, Takahide Nejo, Satoshi Takahashi, Mayu Omata…
    Citation: Acta Neuropathologica Communications 2017 5:18
    Content type: Research Published on:

  14. Cancer microenvironment plays a vital role in cancer development and progression, and cancer-stromal interactions have been recognized as important targets for cancer therapy. However, identifying relevant and...

    Authors: Daisuke Komura, Takayuki Isagawa, Kazuki Kishi, Ryohei Suzuki, Reiko Sato, Mariko Tanaka, Hiroto Katoh, Shogo Yamamoto, Kenji Tatsuno, Masashi Fukayama, Hiroyuki Aburatani and Shumpei Ishikawa
    Citation: BMC Genomics 2016 17:899
    Content type: Methodology article Published on:

  15. Although advanced esophageal squamous-cell carcinoma (ESCC) is treated using a multidisciplinary approach, outcomes remain unsatisfactory. The microenvironment of cancer cells has recently been shown to strong...

    Authors: Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda and Toshiro Niki
    Citation: BMC Cancer 2015 15:82
    Content type: Research article Published on: