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28 result(s) for 'author#Geoffrey S Dow' within BMC
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Citation: Journal for ImmunoTherapy of Cancer 2018 6(Suppl 1):114
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Effects of short-term ambient PM2.5 exposure on cardiovascular disease incidence and mortality among U.S. hemodialysis patients: a retrospective cohort study
Ambient PM2.5 is a ubiquitous air pollutant with demonstrated adverse health impacts in population. Hemodialysis patients are a highly vulnerable population and may be particularly susceptible to the effects of P...
Citation: Environmental Health 2022 21:33 -
Cancer Imaging reviewer acknowledgement 2015
The Editor of Cancer Imaging would like to thank all reviewers who have contributed their time and expertise to the journal in Volume 15 (2015).
Citation: Cancer Imaging 2016 16:2 -
Vegetation fire smoke, indigenous status and cardio-respiratory hospital admissions in Darwin, Australia, 1996–2005: a time-series study
Air pollution in Darwin, Northern Australia, is dominated by smoke from seasonal fires in the surrounding savanna that burn during the dry season from April to November. Our aim was to study the association be...
Citation: Environmental Health 2008 7:42 -
The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg)
Tafenoquine (TQ) is an 8-aminoquinoline anti-malarial being developed for malaria prophylaxis. It has been generally assumed that TQ, administered prophylactically, acts primarily on the developing exoerythroc...
Citation: Malaria Journal 2017 16:209 -
A retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area
In 2000/2001, the Australian Defense Forces (ADF), in collaboration with SmithKline Beecham and the United States Army, conducted a field trial to evaluate the safety, tolerability and efficacy of tafenoquine ...
Citation: Malaria Journal 2014 13:49 -
The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of mefloquine might be mediated through a disruptive effect of ...
Citation: Malaria Journal 2003 2:14 -
Summary of anti-malarial prophylactic efficacy of tafenoquine from three placebo-controlled studies of residents of malaria-endemic countries
Tafenoquine is a long half-life primaquine analog being developed for malaria prophylaxis. The US Army recently performed a unified analysis of efficacy in preparation for a regulatory submission, utilizing le...
Citation: Malaria Journal 2015 14:473 -
Exploring arts-based interventions for youth substance use prevention: a scoping review of literature
There is a rise in problematic substance use among Canadian youth, which is precipitating a public health crisis. Interventions are needed to empower youth to mitigate substance use risks. Active youth involve...
Citation: BMC Public Health 2022 22:2281 -
Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine
There is no known biochemical basis for the adverse neurological events attributed to mefloquine. Identification of genes modulated by toxic agents using microarrays may provide sufficient information to gener...
Citation: Malaria Journal 2003 2:4 -
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice
The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same exte...
Citation: Malaria Journal 2011 10:150 -
Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)
Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance t...
Citation: Malaria Journal 2011 10:212 -
Preliminary study on the effects of treatment for breast cancer: immunological markers as they relate to quality of life and neuropsychological performance
Immunological biomarkers were related to quality of life and neuropsychological performance in women recently diagnosed with breast cancer through the first six months of treatment. A comparison group of breas...
Citation: BMC Women's Health 2020 20:109 -
BMC Medical Education reviewer acknowledgement 2015
The editors of BMC Medical Education would like to thank all our reviewers who have contributed to the journal in Volume 15 (2015).
Citation: BMC Medical Education 2016 16:57 -
Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
The clinical utility for mefloquine has been eroded due to its association with adverse neurological effects. Better-tolerated alternatives are required. The objective of the present study was the identificati...
Citation: Malaria Journal 2010 9:51 -
A Sorghum bicolorexpression atlas reveals dynamic genotype-specific expression profiles for vegetative tissues of grain, sweet and bioenergy sorghums
Effective improvement in sorghum crop development necessitates a genomics-based approach to identify functional genes and QTLs. Sequenced in 2009, a comprehensive annotation of the sorghum genome and the devel...
Citation: BMC Plant Biology 2014 14:35 -
Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus
Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source o...
Citation: BMC Systems Biology 2011 5:68 -
Quantification of the variation in percentage identity for protein sequence alignments
Percentage Identity (PID) is frequently quoted in discussion of sequence alignments since it appears simple and easy to understand. However, although there are several different ways to calculate percentage id...
Citation: BMC Bioinformatics 2006 7:415 -
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (...
Citation: Critical Care 2022 26:276 -
PNAC: a protein nucleolar association classifier
Although primarily known as the site of ribosome subunit production, the nucleolus is involved in numerous and diverse cellular processes. Recent large-scale proteomics projects have identified thousands of hu...
Citation: BMC Genomics 2011 12:74