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20 result(s) for 'author#Douglas J Veale' within BMC
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Citation: Pediatric Rheumatology 2017 15(Suppl 1):44
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Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P49 -
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia
We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell ...
Citation: Arthritis Res Ther 2004 7:R80 -
Correction to: Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups
Following publication of the original article [1], the authors reported an error in the spelling of the ninth author’s name.
Citation: Arthritis Research & Therapy 2018 20:282 -
Remission in psoriatic arthritis: is it possible and how can it be predicted?
Since remission is now possible in psoriatic arthritis (PsA) we wished to examine remission rates in PsA patients following anti tumour necrosis factor alpha (TNFα) therapy and to examine possible predictors o...
Citation: Arthritis Research & Therapy 2010 12:R94 -
Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures
The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells.
Citation: Arthritis Research & Therapy 2011 13:R33 -
Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups
The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG...
Citation: Arthritis Research & Therapy 2018 20:265 -
Comparison of remission criteria in a tumour necrosis factor inhibitor treated rheumatoid arthritis longitudinal cohort: patient global health is a confounder
Our objectives were to assess the frequency and sustainability of American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) and Disease Activity Score (DAS)28(4v)–C-reactive protein (CR...
Citation: Arthritis Research & Therapy 2013 15:R221 -
Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study
With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in ...
Citation: Arthritis Research & Therapy 2011 13:R7 -
Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies
The aim of this study was to examine IL-17A in patients, following anti-TNF-α therapy and the effect of IL-17A on matrix turnover and cartilage degradation.
Citation: Arthritis Research & Therapy 2009 11:R113 -
Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
To examine the effects of tumour necrosis factor (TNF) blocking therapy on the levels of early mitochondrial genome alterations and oxidative stress.
Citation: Arthritis Research & Therapy 2011 13:R121 -
Randomised controlled trial examining the effect of exercise in people with rheumatoid arthritis taking anti-TNFα therapy medication
Substantial progress has been made in the medical management of rheumatoid arthritis (RA) over the past decade with the introduction of biologic therapies, including anti-tumour necrosis factor alpha (anti-TNF...
Citation: BMC Musculoskeletal Disorders 2011 12:11 -
The PD-1:PD-L1 axis in Inflammatory Arthritis
The activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint i...
Citation: BMC Rheumatology 2021 5:1 -
Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus
Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targe...
Citation: Arthritis Research & Therapy 2018 20:85 -
Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis
In this study, we examined the effect of oxidative stress on cellular energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary rheumatoid arthritis synovial fibroblast cells (RASFC) and huma...
Citation: Arthritis Research & Therapy 2018 20:95 -
Toll-like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis
This study investigates the role of Toll-like receptor 2 (TLR2) in the regulation of migratory and invasive mechanisms in rheumatoid arthritis (RA).
Citation: Arthritis Research & Therapy 2015 17:153 -
Long-term remission and biologic persistence rates: 12-year real-world data
Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains ...
Citation: Arthritis Research & Therapy 2021 23:25 -
Genetic determinants of hyaloid and retinal vasculature in zebrafish
The retinal vasculature is a capillary network of blood vessels that nourishes the inner retina of most mammals. Developmental abnormalities or microvascular complications in the retinal vasculature result in ...
Citation: BMC Developmental Biology 2007 7:114 -
ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis—a EUSTAR analysis
To investigate the effect of ACE inhibitors (ACEi) on the incidence of scleroderma renal crisis (SRC) when given prior to SRC in the prospectively collected cohort from the European Scleroderma Trial and Resea...
Citation: Arthritis Research & Therapy 2020 22:59 -
Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database
Patients with diffuse cutaneous systemic sclerosis (dcSSc) have a poor prognosis. The importance of monitoring subjective measures of functioning and disability, such as the Health Assessment Questionnaire-Dis...
Citation: Arthritis Research & Therapy 2020 22:257