Search

4 result(s) for 'author#Dalu Mancama' within BMC

1. In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

   Discovery of novel gametocytocidal molecules is a major pharmacological strategy in the elimination and eradication of malaria. The high patronage of the aqueous root extract of the popular West African anti-m...

   Authors: Arnold Donkor Forkuo, Charles Ansah, Kwesi Boadu Mensah, Kofi Annan, Ben Gyan, Anjo Theron, Dalu Mancama and Colin W. Wright

   Citation: Malaria Journal 2017 16:496

   Content type: Research Published on: 28 December 2017

   • View Full Text
   • View PDF

2. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

   Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiati...

   Authors: John VW Becker, Marina M van der Merwe, Anna C van Brummelen, Pamisha Pillay, Bridget G Crampton, Edwin M Mmutlane, Chris Parkinson, Fanie R van Heerden, Neil R Crouch, Peter J Smith, Dalu T Mancama and Vinesh J Maharaj

   Citation: Malaria Journal 2011 10:295

   Content type: Research Published on: 11 October 2011

   • View Full Text
   • View PDF

3. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

   Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most notably chloroquine and the antifolates. The prevalen...

   Authors: John VW Becker, Linda Mtwisha, Bridget G Crampton, Stoyan Stoychev, Anna C van Brummelen, Shaun Reeksting, Abraham I Louw, Lyn-Marie Birkholtz and Dalu T Mancama

   Citation: BMC Genomics 2010 11:235

   Content type: Research article Published on: 12 April 2010

   • View Full Text
   • View PDF

4. Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

   The discovery of malaria transmission-blocking compounds is seen as key to malaria elimination strategies and gametocyte-screening platforms are critical filters to identify active molecules. However, unlike a...

   Authors: Janette Reader, Mariëtte Botha, Anjo Theron, Sonja B Lauterbach, Claire Rossouw, Dewaldt Engelbrecht, Melanie Wepener, Annél Smit, Didier Leroy, Dalu Mancama, Theresa L Coetzer and Lyn-Marie Birkholtz

   Citation: Malaria Journal 2015 14:213

   Content type: Research Published on: 22 May 2015

   • View Full Text
   • View PDF