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7 result(s) for 'author#Anna McGlothlin' within BMC
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Citation: Genetics Selection Evolution 2016 48:17
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In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol
ClinicalTrials.​gov: NCT03509350. Registered on 26 April 2018.
Citation: Trials 2020 21:351 -
The design of a Bayesian adaptive clinical trial of tranexamic acid in severely injured children
Trauma is the leading cause of death and disability in children in the USA. Tranexamic acid (TXA) reduces the blood transfusion requirements in adults and children during surgery. Several studies have evaluate...
Citation: Trials 2021 22:769 -
The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial
Sepsis accounts for 30% to 50% of all in-hospital deaths in the United States. Other than antibiotics and source control, management strategies are largely supportive with fluid resuscitation and respiratory, ...
Citation: Trials 2019 20:197 -
Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial
Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock.
Citation: Trials 2019 20:670 -
Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analyses
Coronavirus disease 2019 (COVID-19) has exposed the disproportionate effects of pandemics on frontline workers and the ethical imperative to provide effective prophylaxis. We present a model for a pragmatic ra...
Citation: Trials 2022 23:534 -
Implementation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial in a US health system—lessons learned and recommendations
The Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial is a global adaptive platform trial of hospitalized patients with COVID-19. We describe implementation at the first US ...
Citation: Trials 2021 22:100