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27 result(s) for 'author#Andre J. van Wijnen' within BMC
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Citation: Diagnostic and Prognostic Research 2021 5(Suppl 1):7
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Discussion on the use of taxanes for treatment of breast cancers in BRCA1 mutations carriers
Citation: Hereditary Cancer in Clinical Practice 2007 5:119 -
The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
Citation: Molecular Neurodegeneration 2019 14(Suppl 1):30 -
Thanking our peer reviewers
As 2013 commences I would like to take a moment to reflect and recognize the peer reviewers that made the previous year possible. Listed below are those people who reviewed for Molecular Cancer last year. All are...
Citation: Molecular Cancer 2013 12:10 -
Erratum to: RNA sequencing reveals a depletion of collagen targeting microRNAs in Dupuytren’s disease
Citation: BMC Medical Genomics 2016 9:34 -
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers
Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight ...
Citation: Breast Cancer Research 2012 14:R33 -
Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway
Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties in ch...
Citation: Arthritis Research & Therapy 2021 23:47 -
Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial
Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regenerati...
Citation: Stem Cell Research & Therapy 2021 12:187 -
Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis
Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSC...
Citation: Stem Cell Research & Therapy 2021 12:240 -
The value of nonoperative versus operative treatment of frail institutionalized elderly patients with a proximal femoral fracture in the shade of life (FRAIL-HIP); protocol for a multicenter observational cohort study
Proximal femoral fractures are strongly associated with morbidity and mortality in elderly patients. Mortality is highest among frail institutionalized elderly with both physical and cognitive comorbidities wh...
Citation: BMC Geriatrics 2019 19:301 -
A multi-chamber tissue culture device for load-dependent parallel evaluation of tendon explants
Injuries in the musculoskeletal system, such as tendon and ligament ruptures, are challenging to manage and often require surgical reconstructions with limited long-term success. Thus, characterizations of the...
Citation: BMC Musculoskeletal Disorders 2019 20:549 -
hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3
For treatment and prevention of metastatic disease, one of the premier challenges is the identification of pathways and proteins to target for clinical intervention. Micro RNAs (miRNAs) are short, non-coding R...
Citation: Cancer Cell International 2014 14:73 -
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4 (H3K4me3) located after first exons and around transcription start sites. This epigenetic mark is typically restricted ...
Citation: Clinical Epigenetics 2021 13:138 -
The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain
Degeneration of the interverterbral disk is as a cause of low-back pain is increasing. To gain insight into relationships between biological processes, structural alterations and behavioral pain, we created an...
Citation: Arthritis Research & Therapy 2011 13:R165 -
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility
Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely r...
Citation: Breast Cancer Research 2010 12:R89 -
Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes
Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human ...
Citation: Arthritis Research & Therapy 2011 13:R130 -
Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis
Osteogenesis is a highly regulated developmental process and continues during the turnover and repair of mature bone. Runx2, the master regulator of osteoblastogenesis, directs a transcriptional program essent...
Citation: Genome Biology 2014 15:R52 -
Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production
Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes. A...
Citation: Stem Cell Research & Therapy 2016 7:107 -
The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells
Mesenchymal stem cells (MSCs) perform paracrine functions by releasing extracellular vesicles (EVs) containing microRNA, mRNA, and proteins. We investigated the mRNA content of EVs in metabolic syndrome (MetS)...
Citation: Diabetology & Metabolic Syndrome 2018 10:58 -
Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia
Adipose-derived MSC (AMSCs) possess angiogenic and immunomodulatory properties that may modulate kidney regeneration. Whether these properties are retained in older patients with atherosclerotic vascular disea...
Citation: Stem Cell Research & Therapy 2016 7:128