Search

5 result(s) for 'author#"Xu Shiwen"' within BMC

1. Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts

   Platelet-derived growth factor (PDGF) signalling is essential for many key cellular processes in mesenchymal cells. As there is redundancy in signalling between the five PDGF ligand isoforms and three PDGF rec...

   Authors: Johanna Donovan, Xu Shiwen, Jill Norman and David Abraham

   Citation: Fibrogenesis & Tissue Repair 2013 6:10

   Content type: Research

   Published on: 10 May 2013

   • View Full Text
   • View PDF

2. Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues

   Systemic sclerosis (SSc) is a chronic inflammatory autoimmune disease characterised by vascular dysfunction and damage, excess collagen deposition and subsequent organ manifestations. Vasculopathy is an early ...

   Authors: Luke Morgan-Rowe, Joanna Nikitorowicz, Xu Shiwen, Andrew Leask, Janice Tsui, David Abraham and Richard Stratton

   Citation: Fibrogenesis & Tissue Repair 2011 4:13

   Content type: Research

   Published on: 2 June 2011

   • View Full Text
   • View PDF

3. The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis

   The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have exa...

   Authors: Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong and Christopher P. Denton

   Citation: Arthritis Research & Therapy 2021 23:234

   Content type: Research article

   Published on: 6 September 2021

   • View Full Text
   • View PDF

4. Arsenic affects inflammatory cytokine expression in Gallus gallus brain tissues

   The heavy metal arsenic is widely distributed in nature and posses a serious threat to organism’s health. However, little is known about the arsenic-induced inflammatory response in the brain tissues of birds ...

   Authors: Xiao Sun, Ying He, Ying Guo, Siwen Li, Hongjing Zhao, Yu Wang, Jingyu Zhang and Mingwei Xing

   Citation: BMC Veterinary Research 2017 13:157

   Content type: Research article

   Published on: 5 June 2017

   • View Full Text
   • View PDF

5. Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis

   Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial flu...

   Authors: Kristina EN Clark, Henry Lopez, Bahja Ahmed Abdi, Sandra G Guerra, Xu Shiwen, Korsa Khan, Oseme Etomi, George R Martin, David J Abraham, Christopher P Denton and Richard J Stratton

   Citation: Arthritis Research & Therapy 2015 17:73

   Content type: Research article

   Published on: 23 March 2015

   • View Full Text
   • View PDF