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6 result(s) for 'author#"Xiangxiang Zhou"' within BMC

1. Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling

   Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been document...

   Authors: Juan Yang, Ying Li, Ya Zhang, Xiaosheng Fang, Na Chen, Xiangxiang Zhou and Xin Wang

   Citation: Journal of Experimental & Clinical Cancer Research 2020 39:142

   Content type: Research

   Published on: 25 July 2020

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2. The functions and clinical significance of circRNAs in hematological malignancies

   With covalently closed circular structures, circular RNAs (circRNAs) were once misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved, and tissue-specific, circRNAs are recent...

   Authors: Xiangxiang Zhou, Linquan Zhan, Kai Huang and Xin Wang

   Citation: Journal of Hematology & Oncology 2020 13:138

   Content type: Review

   Published on: 17 October 2020

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3. Novel insights into the m⁶A-RNA methyltransferase METTL3 in cancer

   N6-methyladenosine (m⁶A) is a prevalent internal RNA modification in higher eukaryotic cells. As the pivotal m⁶A regulator, RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer in the pr...

   Authors: Yiqing Cai, Rui Feng, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou and Xin Wang

   Citation: Biomarker Research 2021 9:27

   Content type: Review

   Published on: 20 April 2021

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4. Clinical development of phosphatidylinositol 3-kinase inhibitors for non-Hodgkin lymphoma

   Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway is extensively explored in cancers. It functions as an important regulator of cell growth, survival and metabolis...

   Authors: Xiaosheng Fang, Xiangxiang Zhou and Xin Wang

   Citation: Biomarker Research 2013 1:30

   Content type: Review

   Published on: 15 November 2013

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5. Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma

   Hippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism is still poorly understood. At present, the significance of the Hippo-YAP...

   Authors: Xiangxiang Zhou, Na Chen, Hongzhi Xu, Xiaoming Zhou, Jianhong Wang, Xiaosheng Fang, Ya Zhang, Ying Li, Juan Yang and Xin Wang

   Citation: Journal of Hematology & Oncology 2020 13:77

   Content type: Research

   Published on: 16 June 2020

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6. Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

   Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways. T...

   Authors: Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv and Xin Wang

   Citation: Journal of Hematology & Oncology 2017 10:37

   Content type: Research

   Published on: 2 February 2017

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