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5 result(s) for 'author#"Svetlana A Shabalina"' within BMC

1. A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

   All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated (cas) genes that have been previously implicated in a...

   Authors: Kira S Makarova, Nick V Grishin, Svetlana A Shabalina, Yuri I Wolf and Eugene V Koonin

   Citation: Biology Direct 2006 1:7

   Content type: Research

   Published on: 16 March 2006

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2. Computational models with thermodynamic and composition features improve siRNA design

   Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large functional genomics projects.

   Authors: Svetlana A Shabalina, Alexey N Spiridonov and Aleksey Y Ogurtsov

   Citation: BMC Bioinformatics 2006 7:65

   Content type: Methodology article

   Published on: 12 February 2006

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3. Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides: application to HIV genome

   Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequence variants. However, even for regions that are equa...

   Authors: Olga V Matveeva, Brian T Foley, Vladimir A Nemtsov, Raymond F Gesteland, Senya Matsufuji, John F Atkins, Aleksey Y Ogurtsov and Svetlana A Shabalina

   Citation: BMC Bioinformatics 2004 5:44

   Content type: Methodology article

   Published on: 29 April 2004

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4. The mammalian transcriptome and the function of non-coding DNA sequences

   For decades, researchers have focused most of their attention on protein-coding genes and proteins. With the completion of the human and mouse genomes and the accumulation of data on the mammalian transcriptom...

   Authors: Svetlana A Shabalina and Nikolay A Spiridonov

   Citation: Genome Biology 2004 5:105

   Content type: Opinion

   Published on: 25 March 2004

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5. Evolution of alternative and constitutive regions of mammalian 5'UTRs

   Alternative splicing (AS) in protein-coding sequences has emerged as an important mechanism of regulation and diversification of animal gene function. By contrast, the extent and roles of alternative events in...

   Authors: Alissa M Resch, Aleksey Y Ogurtsov, Igor B Rogozin, Svetlana A Shabalina and Eugene V Koonin

   Citation: BMC Genomics 2009 10:162

   Content type: Research article

   Published on: 16 April 2009

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