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5 result(s) for 'author#"Hiroshi Yatsuhashi"' within BMC

1. Genetic risk factors for autoimmune hepatitis: implications for phenotypic heterogeneity and biomarkers for drug response

   Autoimmune hepatitis (AIH) is a rare chronic progressive liver disease with autoimmune features. It mainly affects middle-aged women. AIH is occasionally complicated with liver cirrhosis that worsens the progn...

   Authors: Takashi Higuchi, Shomi Oka, Hiroshi Furukawa, Shigeto Tohma, Hiroshi Yatsuhashi and Kiyoshi Migita

   Citation: Human Genomics 2021 15:6

   Content type: Review

   Published on: 28 January 2021

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2. JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells

   Innate immune cells play a crucial role in the pathophysiology of rheumatoid arthritis (RA) via release of cytokines. Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients wi...

   Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Furuya-Yashiro, Tomoyuki Asano, Shuzo Sato, Haruki Matsumoto, Hiroshi Watanabe, Hideko Kozuru, Hiroshi Yatsuhashi, Atsushi Kawakami and Kiyoshi Migita

   Citation: BMC Immunology 2020 21:35

   Content type: Research article

   Published on: 15 June 2020

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3. Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils

   Granulocyte–macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine that activates myeloid cells to initiate tissue inflammation. However, the molecular actions of GM-CSF against innate...

   Authors: Makiko Yashiro Furuya, Tomoyuki Asano, Yuya Sumichika, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Hiromasa Ohira, Hideharu Sekine, Atsushi Kawakami and Kiyoshi Migita

   Citation: Arthritis Research & Therapy 2018 20:196

   Content type: Research article

   Published on: 29 August 2018

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4. Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils

   Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is involved in autoinflammation.

   Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Takeshi Urano, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita

   Citation: Arthritis Research & Therapy 2019 21:250

   Content type: Research article

   Published on: 27 November 2019

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5. Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population

   Previous genome-wide association studies have evaluated the impact of common genetic variants and identified several non-HLA risk loci associated with autoimmune liver diseases. More recent genome-wide associa...

   Authors: Kiyoshi Migita, Yuka Jiuchi, Hiroshi Furukawa, Minoru Nakamura, Atsumasa Komori, Michio Yasunami, Hideko Kozuru, Seigo Abiru, Kazumi Yamasaki, Shinya Nagaoka, Satoru Hashimoto, Shigemune Bekki, Kaname Yoshizawa, Masaaki Shimada, Hiroshi Kouno, Hiroshi Kamitsukasa…

   Citation: BMC Research Notes 2015 8:777

   Content type: Short Report

   Published on: 12 December 2015

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