Citation: Trials 2017 18(Suppl 1):200
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30 result(s) for 'author#"Corinne Alberti"' within BMC
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Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia
High-dose steroid therapy has been proven effective in AIDS-related Pneumocystis pneumonia (PCP) but not in non-AIDS-related cases. We evaluated the effects on survival of steroids in HIV-negative patients wit...
Citation: Respiratory Research 2013 14:87
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Experimental designs for small randomised clinical trials: an algorithm for choice
Small clinical trials are necessary when there are difficulties in recruiting enough patients for conventional frequentist statistical analyses to provide an appropriate answer. These trials are often necessar...
Citation: Orphanet Journal of Rare Diseases 2013 8:48
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Identifying potential indicators to measure the outcome of translational cancer research: a mixed methods approach
In a context where there is an increasing demand to evaluate the outcome of bio-medical research, our work aims to develop a set of indicators to measure the impact of translational cancer research. The object...
Citation: Health Research Policy and Systems 2015 13:72
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Reliability of ultrasound measurements of quadriceps muscle thickness in critically ill patients
Muscle wasting in critically ill patients is associated with negative clinical outcomes. Ultrasound quadriceps femoris muscle assessment may constitute a convenient tool to evaluate muscle wasting. Nevertheless, ...
Citation: BMC Anesthesiology 2018 18:205
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How to collect non-medical data in a pediatric trial: diaries or interviews
Non-medical data, such as the amount of time that patients and caregivers spend managing their condition, may be relevant when assessing therapeutic strategies. For chronic pediatric conditions, the time that ...
Citation: Trials 2020 21:36
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Cognitive status of patients judged fit for discharge from the post-anaesthesia care unit after general anaesthesia: a randomized comparison between desflurane and propofol
The Aldrete’s score is used to determine when a patient can safely leave the Post-Anaesthesia Care Unit (PACU) and be transferred to the surgical ward. The Aldrete score is based on the evaluation of vital sig...
Citation: BMC Anesthesiology 2021 21:76
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VITamin D supplementation in renAL transplant recipients (VITALE): a prospective, multicentre, double-blind, randomized trial of vitamin D estimating the benefit and safety of vitamin D3 treatment at a dose of 100,000 UI compared with a dose of 12,000 UI in renal transplant recipients: study protocol for a double-blind, randomized, controlled trial
In addition to their effects on bone health, high doses of cholecalciferol may have beneficial non-classic effects including the reduction of incidence of type 2 diabetes mellitus, cardiovascular disease, and ...
Citation: Trials 2014 15:430
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Comparison of two data collection processes in clinical studies: electronic and paper case report forms
Electronic Case Report Forms (eCRFs) are increasingly chosen by investigators and sponsors of clinical research instead of the traditional pen-and-paper data collection (pCRFs). Previous studies suggested that...
Citation: BMC Medical Research Methodology 2014 14:7
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Stature is an essential predictor of muscle strength in children
Children with growth retardation or short stature generally present with lower strength than children of the same chronological age. The aim of the study was to establish if strength was dependent on variables...
Citation: BMC Musculoskeletal Disorders 2012 13:176
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A Bayesian non-inferiority approach using experts’ margin elicitation – application to the monitoring of safety events
When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have be...
Citation: BMC Medical Research Methodology 2019 19:187
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Oral health related quality of life of children and adolescents affected by rare orofacial diseases: a questionnaire-based cohort study
Rare diseases affecting the teeth, the oral cavity and the face are numerous, each of them present specific characteristics, and is a life-long condition. The aim of the study was to assess the association bet...
Citation: Orphanet Journal of Rare Diseases 2019 14:124
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Abnormal bone mineral density and content in girls with early-onset anorexia nervosa
Early-onset anorexia nervosa (EO-AN) represents a significant clinical burden to paediatric and mental health services. The impact of EO-AN on bone mineral abnormalities has not been thoroughly investigated du...
Citation: Journal of Eating Disorders 2021 9:9
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Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE)
Although antenatal betamethasone is recommended worldwide for women at risk of preterm delivery, concerns persist regarding the long-term effects associated with this treatment. Indeed, adverse events, mainly ...
Citation: BMC Pregnancy and Childbirth 2019 19:67
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Outcomes used in randomised controlled trials of nutrition in the critically ill: a systematic review
No evidence exists to date on which to base the selection of outcome measures for assessing nutritional interventions in critically ill patients. We conducted a systematic literature review to describe the out...
Citation: Critical Care 2019 23:12
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Academic pediatric clinical research: factors associated with study implementation duration
The ethical, methodological, and technical aspects of pediatric research, often results in complications and delays in implementation. Our objective was to identify factors associated with the implementation d...
Citation: BMC Medical Research Methodology 2016 16:36
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How can we optimise inhaled beta2 agonist dose as ‘reliever’ medicine for wheezy pre-school children? Study protocol for a randomised controlled trial
Asthma is a common problem in children and, if inadequately controlled, may seriously diminish their quality of life. Inhaled short-acting beta2 agonists such as salbutamol are usually prescribed as ‘reliever’...
Citation: Trials 2016 17:541
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A governmental program to encourage medical students to deliver primary prevention: experiment and evaluation in a French faculty of medicine
A public health student service was set up by the French government in 2018 with the aim of increasing awareness of primary health promotion among the 47,000 students of medicine and other health professions. ...
Citation: BMC Medical Education 2021 21:47
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The PRINTEMPS study: protocol of a cluster-randomized controlled trial of the local promotion of a smartphone application and associated website for the prevention of suicidal behaviors in the adult general population in France
Suicide constitutes a cause of death which could be prevented by e-health programs accessible to the general population. Effective promotion has the potential to maximize the uptake of such programs. However, ...
Citation: Trials 2020 21:553
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A methodological framework for drug development in rare diseases
Developing orphan drugs is challenging because of their severity and the requisite for effective drugs. The small number of patients does not allow conducting adequately powered randomized controlled trials (R...
Citation: Orphanet Journal of Rare Diseases 2014 9:164