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28 result(s) for 'author#"Christopher P. Denton"' within BMC

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  2. Foot problems associated with Systemic Sclerosis (SSc)/Scleroderma have been reported to be both common and disabling. There are only limited data describing specifically, the mechanical changes occurring in t...

    Authors: Begonya Alcacer-Pitarch, Maya H Buch, Janine Gray, Christopher P Denton, Ariane Herrick, Nuria Navarro-Coy, Howard Collier, Lorraine Loughrey, Sue Pavitt, Heidi J Siddle, Jonathan Wright, Philip S Helliwell, Paul Emery and Anthony C Redmond

    Citation: BMC Musculoskeletal Disorders 2012 13:11

    Content type: Study protocol

    Published on:

  4. Authors: Yunliang Chen, Andrew Leask, David J Abraham, Laura Kennedy, Xu Shi-wen, Christopher P Denton, Carol M Black, Liaquat S Verjee and Mark Eastwood

    Citation: Fibrogenesis & Tissue Repair 2015 8:4

    Content type: Erratum

    Published on:

    The original article was published in Fibrogenesis & Tissue Repair 2011 4:9

  5. Authors: Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask and Mohit Kapoor

    Citation: Arthritis Research & Therapy 2011 13:402

    Content type: Erratum

    Published on:

    The original article was published in Arthritis Research & Therapy 2011 13:R6

  6. Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborat...

    Authors: Lewis J Rubin, Carol M Black, Christopher P Denton and James R Seibold

    Citation: Arthritis Research & Therapy 2007 9(Suppl 2):S10

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  7. Systemic sclerosis (SSc) is an immune-mediated fibrotic disease affecting skin, lung and gut which are all sites with an established microbiome. Altered microbial flora may occur and contribute to the initiati...

    Authors: Christopher P. Denton and Charles Murray

    Citation: Arthritis Research & Therapy 2019 21:81

    Content type: Editorial

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:49

  8. The mechanism underlying the ability of fibroblasts to contract a collagen gel matrix is largely unknown. Fibroblasts from scarred (lesional) areas of patients with the fibrotic disease scleroderma show enhanc...

    Authors: Yunliang Chen, Andrew Leask, David J Abraham, Laura Kennedy, Xu Shi-wen, Christopher P Denton, Carol M Black, Liaquat S Verjee and Mark Eastwood

    Citation: Fibrogenesis & Tissue Repair 2011 4:9

    Content type: Research

    Published on:

    The Erratum to this article has been published in Fibrogenesis & Tissue Repair 2015 8:4

  9. Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease d...

    Authors: David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2021 23:10

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:73

  10. Interstitial lung disease is a major cause of morbidity and mortality in systemic sclerosis (SSc), with insufficiently effective treatment options. Progression of pulmonary fibrosis involves expanding populati...

    Authors: Gisela E Lindahl, Carmel JW Stock, Xu Shi-Wen, Patricia Leoni, Piersante Sestini, Sarah L Howat, George Bou-Gharios, Andrew G Nicholson, Christopher P Denton, Jan C Grutters, Toby M Maher, Athol U Wells, David J Abraham and Elisabetta A Renzoni

    Citation: Respiratory Research 2013 14:80

    Content type: Research

    Published on:

  11. The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have exa...

    Authors: Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong and Christopher P. Denton

    Citation: Arthritis Research & Therapy 2021 23:234

    Content type: Research article

    Published on:

  12. We assessed the profile and frequency of malignancy subtypes in a large single-centre UK cohort for patients with scleroderma (systemic sclerosis; SSc). We evaluated the cancer risk among SSc patients with dif...

    Authors: Pia Moinzadeh, Carmen Fonseca, Martin Hellmich, Ami A Shah, Cecilia Chighizola, Christopher P Denton and Voon H Ong

    Citation: Arthritis Research & Therapy 2014 16:R53

    Content type: Research article

    Published on:

  13. The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that microvascular pericytes constitute a cellular link betwee...

    Authors: Vineeth S Rajkumar, Kevin Howell, Katalin Csiszar, Christopher P Denton, Carol M Black and David J Abraham

    Citation: Arthritis Research & Therapy 2005 7:R1113

    Content type: Research article

    Published on:

  14. Microsomal prostaglandin E2 synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase (COX) to specifically catalyze the conversion of prostaglandin (PG) H2 to PGE2. mPGES-1 plays a key r...

    Authors: Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask and Mohit Kapoor

    Citation: Arthritis Research & Therapy 2011 13:R6

    Content type: Research article

    Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2011 13:402

  15. Patients with mean pulmonary artery pressures (mPAP) of 21 to 24 mm Hg have a so-called borderline elevation of mPAP (BoPAP)—a condition thought to represent early-stage pulmonary arterial vasculopathy. Based ...

    Authors: Scott H Visovatti, Oliver Distler, J Gerry Coghlan, Christopher P Denton, Ekkehard Grünig, Diana Bonderman, Ulf Müller-Ladner, Janet E Pope, Madelon C Vonk, James R Seibold, Juan-Vicente Torres-Martin, Martin Doelberg, Harbajan Chadha-Boreham, Daniel M Rosenberg, Vallerie V McLaughlin and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2014 16:493

    Content type: Research article

    Published on:

  16. Vasculopathy, including altered vasoreactivity and abnormal large vessel biomechanics, is a hallmark of systemic sclerosis (SSc). However, the pathogenic link with other aspects of the disease is less clear. T...

    Authors: Emma C Derrett-Smith, Audrey Dooley, Korsa Khan, Xu Shi-wen, David Abraham and Christopher P Denton

    Citation: Arthritis Research & Therapy 2010 12:R69

    Content type: Research article

    Published on:

  17. Transforming growth factor beta (TGFβ), a multifunctional cytokine, plays a crucial role in the accumulation of extracellular matrix components in lung fibrosis, where lung fibroblasts are considered to play a...

    Authors: Elisabetta A Renzoni, David J Abraham, Sarah Howat, Xu Shi-Wen, Piersante Sestini, George Bou-Gharios, Athol U Wells, Srihari Veeraraghavan, Andrew G Nicholson, Christopher P Denton, Andrew Leask, Jeremy D Pearson, Carol M Black, Kenneth I Welsh and Roland M du Bois

    Citation: Respiratory Research 2004 5:24

    Content type: Research

    Published on:

  18. CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, cl...

    Authors: Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper C Broen, Madelon C Vonk, Raquel Ríos-Fernández, Gerard Espinosa, Patricia Carreira, María T Camps, Maria J Castillo, Miguel A González-Gay, Emma Beltrán, María del Carmen Freire, Javier Narváez, Carlos Tolosa, Torsten Witte…

    Citation: Arthritis Research & Therapy 2012 14:R85

    Content type: Research article

    Published on:

  20. Pulmonary arterial hypertension (PAH) is a serious complication of systemic sclerosis (SSc). In clinical trials PAH-SSc has been grouped with other forms, including idiopathic PAH. The primary endpoint for mos...

    Authors: Christopher P Denton, Jerome Avouac, Frank Behrens, Daniel E Furst, Ivan Foeldvari, Marc Humbert, Doerte Huscher, Otylia Kowal-Bielecka, Marco Matucci-Cerinic, Peter Nash, Christian F Opitz, David Pittrow, Lewis J Rubin, James R Seibold and Oliver Distler

    Citation: Arthritis Research & Therapy 2011 13:114

    Content type: Commentary

    Published on: