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Yeast biotechnology

Edited by Prof Diethard Mattanovich

Microbial Cell Factories invites submissions to the recently launched thematic series on “Yeast biotechnology”.

Mankind has exploited the metabolic activities of yeasts in baking and brewing for several millennia. The invention of the fed-batch technology for production of bakers' yeast has been a cornerstone of modern biotechnology, enabling the development of efficient production processes for antibiotics, biopharmaceuticals and technical enzymes. Alcoholic fermentation, on the other hand, is a model for microbial metabolite production and has become a major research focus for the manufacturing of biofuels. Expanding from our knowledge on bakers' yeast, diverse yeast species are explored today. The series highlights the latest research to produce biopharmaceuticals, enzymes, alcohols, organic acids, flavours and fine chemicals, underlining the huge potential of yeast biotechnology.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

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  1. Content type: Research

    Cultivation of recombinant Pichia pastoris (Komagataella sp.) under hypoxic conditions has a strong positive effect on specific productivity when the glycolytic GAP promoter is used for recombinant protein expres...

    Authors: Núria Adelantado, Pablo Tarazona, Karlheinz Grillitsch, Xavier García-Ortega, Sergi Monforte, Francisco Valero, Ivo Feussner, Günther Daum and Pau Ferrer

    Citation: Microbial Cell Factories 2017 16:86

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  2. Content type: Research

    Bacterial inclusion bodies (IBs) are non-toxic protein aggregates commonly produced in recombinant bacteria. They are formed by a mixture of highly stable amyloid-like fibrils and releasable protein species wi...

    Authors: Fabián Rueda, Brigitte Gasser, Alejandro Sánchez-Chardi, Mònica Roldán, Sandra Villegas, Verena Puxbaum, Neus Ferrer-Miralles, Ugutz Unzueta, Esther Vázquez, Elena Garcia-Fruitós, Diethard Mattanovich and Antonio Villaverde

    Citation: Microbial Cell Factories 2016 15:166

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  3. Content type: Research

    Glycosylation of flavonoids is a promising approach to improve the pharmacokinetic properties and biological activities of flavonoids. Recently, many efforts such as enzymatic biocatalysis and the engineered Esch...

    Authors: Huimin Wang, Yan Yang, Lin Lin, Wenlong Zhou, Minzhi Liu, Kedi Cheng and Wei Wang

    Citation: Microbial Cell Factories 2016 15:134

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  4. Content type: Research

    The yeast amino acid catabolism plays an important role in flavour generation since higher alcohols and acetate esters, amino acid catabolism end products, are key components of overall flavour and aroma in fe...

    Authors: Jiri Stribny, Gabriele Romagnoli, Roberto Pérez-Torrado, Jean-Marc Daran and Amparo Querol

    Citation: Microbial Cell Factories 2016 15:51

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  5. Content type: Research

    Raspberry ketone is the primary aroma compound found in raspberries and naturally derived raspberry ketone is a valuable flavoring agent. The economic incentives for the production of raspberry ketone, combine...

    Authors: Danna Lee, Natoiya D. R. Lloyd, Isak S. Pretorius and Anthony R. Borneman

    Citation: Microbial Cell Factories 2016 15:49

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  6. Content type: Research

    With increasing concern about the environmental impact of a petroleum based economy, focus has shifted towards greener production strategies including metabolic engineering of microbes for the conversion of pl...

    Authors: Sarah Rodriguez, Charles M. Denby, T. Van Vu, Edward E. K. Baidoo, George Wang and Jay D. Keasling

    Citation: Microbial Cell Factories 2016 15:48

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  7. Content type: Research

    Several plant diterpenes have important biological properties. Among them, forskolin is a complex labdane-type diterpene whose biological activity stems from its ability to activate adenylyl cyclase and to ele...

    Authors: Codruta Ignea, Efstathia Ioannou, Panagiota Georgantea, Fotini A. Trikka, Anastasia Athanasakoglou, Sofia Loupassaki, Vassilios Roussis, Antonios M. Makris and Sotirios C. Kampranis

    Citation: Microbial Cell Factories 2016 15:46

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  8. Content type: Research

    Lactic acid is a versatile chemical platform with many different industrial applications. Yeasts have been demonstrated as attractive alternative to natural lactic acid producers since they can grow at low pH,...

    Authors: Nadia Maria Berterame, Danilo Porro, Diletta Ami and Paola Branduardi

    Citation: Microbial Cell Factories 2016 15:39

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  9. Content type: Research

    Saccharomyces cerevisiae can be engineered to perform a multitude of different chemical reactions that are not programmed in its original genetic code. It has a large potential to func...

    Authors: Jan Dines Knudsen, Cecilia Hägglöf, Nora Weber and Magnus Carlquist

    Citation: Microbial Cell Factories 2016 15:37

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  10. Content type: Research

    Fermentative aromas play a key role in the organoleptic profile of young wines. Their production depends both on yeast strain and fermentation conditions. A present-day trend in the wine industry consists in d...

    Authors: Stéphanie Rollero, Jean-Roch Mouret, Isabelle Sanchez, Carole Camarasa, Anne Ortiz-Julien, Jean-Marie Sablayrolles and Sylvie Dequin

    Citation: Microbial Cell Factories 2016 15:32

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  11. Content type: Research

    Imidazolium ionic liquids (IILs) underpin promising technologies that generate fermentable sugars from lignocellulose for future biorefineries. However, residual IILs ar...

    Authors: Quinn Dickinson, Scott Bottoms, Li Hinchman, Sean McIlwain, Sheena Li, Chad L. Myers, Charles Boone, Joshua J. Coon, Alexander Hebert, Trey K. Sato, Robert Landick and Jeff S. Piotrowski

    Citation: Microbial Cell Factories 2016 15:17

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  12. Content type: Commentary

    Promoters are indispensable elements of a standardized parts collection for synthetic biology. Regulated promoters of a wide variety of well-defined induction ratios and expression strengths are highly interes...

    Authors: Brigitte Gasser, Matthias G. Steiger and Diethard Mattanovich

    Citation: Microbial Cell Factories 2015 14:196

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  13. Content type: Research

    Lignocellulosic substrates and pulping process streams are of increasing relevance to biorefineries for second generation biofuels and biochemical production. They are known to be rich in sugars and inhibitors...

    Authors: Peter Temitope Adeboye, Maurizio Bettiga, Fredrik Aldaeus, Per Tomas Larsson and Lisbeth Olsson

    Citation: Microbial Cell Factories 2015 14:149

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  14. Content type: Research

    Glutathione (GSH), a pivotal non-protein thiol, can be biosynthesized through three pathways in different organisms: (1) two consecutive enzymatic reactions catalyzed by γ-glutamylcysteine synthetase (Gsh1 or ...

    Authors: Liang Tang, Weiwei Wang, Wenlong Zhou, Kai Cheng, Yan Yang, Minzhi Liu, Kedi Cheng and Wei Wang

    Citation: Microbial Cell Factories 2015 14:139

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  15. Content type: Research

    Monoterpenes are important contributors to grape and wine aroma. Moreover, certain monoterpenes have been shown to display health benefits with antimicrobial, anti-inflammatory, anticancer or hypotensive prope...

    Authors: Ester Pardo, Juan Rico, José Vicente Gil and Margarita Orejas

    Citation: Microbial Cell Factories 2015 14:136

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  16. Content type: Research

    Saccharomyces cerevisiae has become a popular host for production of non-native compounds. The metabolic pathways involved generally require a n...

    Authors: Tim Vos, Pilar de la Torre Cortés, Walter M. van Gulik, Jack T. Pronk and Pascale Daran-Lapujade

    Citation: Microbial Cell Factories 2015 14:133

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  17. Content type: Research

    Aroma is one of the most important attributes defining wine quality in which yeasts play a crucial role, synthesizing aromatic compounds or releasing odourless conjugate...

    Authors: Amparo Gamero, Carmela Belloch and Amparo Querol

    Citation: Microbial Cell Factories 2015 14:128

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  18. Content type: Research

    The introduction of yeast starter cultures consisting in a blend of Saccharomyces cerevisiae and non-Saccharomyces yeast strains is emerging for...

    Authors: Catarina Barbosa, Arlete Mendes-Faia, Patrícia Lage, Nuno P. Mira and Ana Mendes-Ferreira

    Citation: Microbial Cell Factories 2015 14:124

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  19. Content type: Research

    A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase (PDC) genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for the production of pyruv...

    Authors: Yiming Zhang, Guodong Liu, Martin K M Engqvist, Anastasia Krivoruchko, Björn M Hallström, Yun Chen, Verena Siewers and Jens Nielsen

    Citation: Microbial Cell Factories 2015 14:116

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  20. Content type: Research

    Sugar alcohols have been widely applied in the fields of food and medicine owing to their unique properties. Compared to chemical production, microbial production of sugar alcohols has become attractive becaus...

    Authors: Guoqiang Zhang, Yuping Lin, Xianni Qi, Lixian Wang, Peng He, Qinhong Wang and Yanhe Ma

    Citation: Microbial Cell Factories 2015 14:112

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  21. Content type: Research

    Membrane proteins are important drug targets in many human diseases and gathering structural information regarding these proteins encourages the pharmaceutical industry ...

    Authors: Augusto Q Pedro, Luís M Martins, João M L Dias, Maria J Bonifácio, João A Queiroz and Luís A Passarinha

    Citation: Microbial Cell Factories 2015 14:113

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