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World Cancer Day 2022

Close the Care Gap

One in two people will develop cancer at some point in their lives. Cancer has become the second-leading cause of death in the world, with 70% of cancer deaths occurring in low-to-middle income countries. Cancer also carries a heavy global economic toll estimated at $1.16 trillion per annum. 

Cancer can be caused by a number of different risk factors. Whilst some risk factors cannot be controlled, such as age and genetics, around one third of cancer cases are preventable through reducing dietary, lifestyle and behavioural risks. These raise the need for effective actions through country-specific plans to reduce and prevent cancer, but unfortunately such programmes are disproportionately underfunded.

Incredible advancements in cancer screening, early detection and treatments mean that more patients with cancer are living longer. Yet, cancer survivors face physical and financial problems associated with cancer treatment as well as psychological and emotional burdens. Cancer recurrence is also a risk.

This year’s theme for World Cancer Day is “Close the Care Gap”. Half of the world’s population lacks access to essential health services, creating an equity gap based on socioeconomics, demographics, age, race, gender and disabilities. Disadvantaged groups are more likely to have increased exposures to modifiable risk factors, delayed diagnoses and limited access to the best cancer treatments and support.

In this spirit, the Editors of BMC Medicine are delighted to share with you a selection of key papers that highlight some of the most proactive research in cancer prevention, screening and control published in the journal, some of which highlight cancer research on underrepresented groups and address inequities to mark World Cancer Day 2022.


World Cancer Day 2022


  1. It is not a rare clinical scenario to have patients presenting with coexisting malignant tumor and tuberculosis. Whether it is feasible to conduct programmed death-(ligand) 1 [PD-(L)1] inhibitors to these pati...

    Authors: Shan Su, Mei-Feng Ye, Xiao-Ting Cai, Xue Bai, Zhi-Hao Huang, Si-Cong Ma, Jian-Jun Zou, Yu-Xiang Wen, Li-Juan Wu, Xue-Jun Guo, Xian-Lan Zhang, Wen-Chang Cen, Duo-Hua Su, Hui-Yi Huang and Zhong-Yi Dong
    Citation: BMC Medicine 2021 19:322
  2. Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we obs...

    Authors: Mathilde His, Vivian Viallon, Laure Dossus, Julie A. Schmidt, Ruth C. Travis, Marc J. Gunter, Kim Overvad, Cecilie Kyrø, Anne Tjønneland, Lucie Lécuyer, Joseph A. Rothwell, Gianluca Severi, Theron Johnson, Verena Katzke, Matthias B. Schulze, Giovanna Masala…
    Citation: BMC Medicine 2021 19:312
  3. Colorectal cancer (CRC) is the leading cause of cancer death worldwide. Screening is a confirmed way to reduce the incidence and mortality rates of CRC. This study aimed to identify a fecal-based, noninvasive,...

    Authors: Lian-Jing Cao, Xiao-Lin Peng, Wen-Qiong Xue, Rong Zhang, Jiang-Bo Zhang, Ting Zhou, Zi-Yi Wu, Gai-Rui Li, Tong-Min Wang, Yong-Qiao He, Da-Wei Yang, Ying Liao, Xia-Ting Tong, Fang Wang, Ke-Xin Chen, Shi-Hong Zhang…
    Citation: BMC Medicine 2021 19:250
  4. Plasma cell-free DNA (cfDNA) methylation has shown promising results in the early detection of multiple cancers recently. Here, we conducted a study to investigate the performance of cfDNA methylation in the e...

    Authors: Guibin Qiao, Weitao Zhuang, Bo Dong, Chengcheng Li, Jiayue Xu, Guoqiang Wang, Liang Xie, Zihao Zhou, Dan Tian, Gang Chen, Jiming Tang, Haiyu Zhou, Dongkun Zhang, Ruiqing Shi, Rixin Chen, Weiqi Nian…
    Citation: BMC Medicine 2021 19:243
  5. To investigate how socioeconomic position (SEP) influences the effectiveness of cancer-directed treatment in premenopausal breast cancer patients in terms of breast cancer recurrence and mortality.

    Authors: Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sørensen and Deirdre Cronin-Fenton
    Citation: BMC Medicine 2021 19:235

    The Correction to this article has been published in BMC Medicine 2023 21:311

  6. Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability,...

    Authors: Pek Kei Im, Iona Y. Millwood, Christiana Kartsonaki, Yu Guo, Yiping Chen, Iain Turnbull, Canqing Yu, Huaidong Du, Pei Pei, Jun Lv, Robin G. Walters, Liming Li, Ling Yang and Zhengming Chen
    Citation: BMC Medicine 2021 19:216
  7. Significant improvements in mortality among patients with non-small cell lung cancer (NSCLC) in the USA over the past two decades have been reported based on Surveillance, Epidemiology, and End Results (SEER) ...

    Authors: Sreeram Ramagopalan, Thomas P. Leahy, Joshua Ray, Samantha Wilkinson, Cormac Sammon and Vivek Subbiah
    Citation: BMC Medicine 2021 19:209
  8. Current methods for cervical cancer screening result in an increased number of referrals and unnecessary diagnostic procedures. This study aimed to develop and evaluate a more accurate model for cervical cance...

    Authors: Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao and Wen Chen
    Citation: BMC Medicine 2021 19:197
  9. The optimal posttreatment surveillance strategy for nasopharyngeal carcinoma (NPC) remains unclear. Circulating cell-free Epstein-Barr virus (cfEBV) DNA has been recognized as a promising biomarker to facilita...

    Authors: Chen-Fei Wu, Li Lin, Yan-Ping Mao, Bin Deng, Jia-Wei Lv, Wei-Hong Zheng, Dan-Wan Wen, Jia Kou, Fo-Ping Chen, Xing-Li Yang, Si-Si Xu, Jun Ma, Guan-Qun Zhou and Ying Sun
    Citation: BMC Medicine 2021 19:193
  10. The risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences in vitro gene expression and cancer cell growth. We sought to determin...

    Authors: P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington and M. G. Dunlop
    Citation: BMC Medicine 2021 19:174
  11. Glucocorticoids could theoretically decrease breast cancer risk through their anti-inflammatory effects or increase risk through immunosuppression. However, epidemiological evidence is limited regarding the as...

    Authors: Manon Cairat, Marie Al Rahmoun, Marc J. Gunter, Pierre-Etienne Heudel, Gianluca Severi, Laure Dossus and Agnès Fournier
    Citation: BMC Medicine 2021 19:186

    The Commentary to this article has been published in BMC Medicine 2021 19:187

  12. Randomized controlled trials have shown a higher sensitivity and longer negative predictive value of high-risk human papillomavirus (HPV) testing than cytology for cervical cancer screening; however, little is...

    Authors: Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang and Jiuling Wu
    Citation: BMC Medicine 2021 19:164

    The Commentary to this article has been published in BMC Medicine 2021 19:165

  13. Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with...

    Authors: Ce Sun, Ke Li, Huan Xu, Xiangjun Wang, Pengzhe Qin, Suixiang Wang, Boheng Liang and Lin Xu
    Citation: BMC Medicine 2021 19:158
  14. The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two o...

    Authors: Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, José María Huerta, Anne Tjønneland, Jytte Halkjær…
    Citation: BMC Medicine 2021 19:101
  15. Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone recepto...

    Authors: Michèle Matta, Inge Huybrechts, Carine Biessy, Corinne Casagrande, Sahar Yammine, Agnès Fournier, Karina Standahl Olsen, Marco Lukic, Inger Torhild Gram, Eva Ardanaz, Maria-José Sánchez, Laure Dossus, Renée T. Fortner, Bernard Srour, Franziska Jannasch, Matthias B. Schulze…
    Citation: BMC Medicine 2021 19:81
  16. Although a potential inverse association between vegetable intake and bladder cancer risk has been reported, epidemiological evidence is inconsistent. This research aimed to elucidate the association between v...

    Authors: Evan Yi-Wen Yu, Anke Wesselius, Siamak Mehrkanoon, Mieke Goosens, Maree Brinkman, Piet van den Brandt, Eric J. Grant, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc J. Gunter, Inge Huybrechts, Elio Riboli, Anne Tjonneland, Giovanna Masala, Graham G. Giles…
    Citation: BMC Medicine 2021 19:56
  17. Artificial intelligence (AI) in diagnostic radiology is undergoing rapid development. Its potential utility to improve diagnostic performance for cardiopulmonary events is widely recognized, but the accuracy a...

    Authors: Jordan Chamberlin, Madison R. Kocher, Jeffrey Waltz, Madalyn Snoddy, Natalie F. C. Stringer, Joseph Stephenson, Pooyan Sahbaee, Puneet Sharma, Saikiran Rapaka, U. Joseph Schoepf, Andres F. Abadia, Jonathan Sperl, Phillip Hoelzer, Megan Mercer, Nayana Somayaji, Gilberto Aquino…
    Citation: BMC Medicine 2021 19:55
  18. The World Health Assembly has adopted a global strategy to eliminate cervical cancer. However, neither the optimal pathway nor the corresponding economic and health benefits have been evaluated. We take China ...

    Authors: Changfa Xia, Xiaoqian Xu, Xuelian Zhao, Shangying Hu, Youlin Qiao, Yong Zhang, Raymond Hutubessy, Partha Basu, Nathalie Broutet, Mark Jit and Fanghui Zhao
    Citation: BMC Medicine 2021 19:62
  19. Sex hormones have been suggested to play a role in colorectal cancer (CRC), but their influence on early initiation of CRC remains unknown.

    Authors: Dong Hang, Xiaosheng He, Ane Sørlie Kværner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci and Mingyang Song
    Citation: BMC Medicine 2021 19:18
  20. A high body mass index (BMI) has been associated with increased risk of several cancers; however, whether BMI is related to a larger number of cancers than currently recognized is unclear. Moreover, whether wa...

    Authors: Martina Recalde, Veronica Davila-Batista, Yesika Díaz, Michael Leitzmann, Isabelle Romieu, Heinz Freisling and Talita Duarte-Salles
    Citation: BMC Medicine 2021 19:10
  21. Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relatio...

    Authors: Solange Parra-Soto, Emma S. Cowley, Leandro F. M. Rezende, Catterina Ferreccio, John C. Mathers, Jill P. Pell, Frederick K. Ho and Carlos Celis-Morales
    Citation: BMC Medicine 2021 19:7
  22. Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle ...

    Authors: Krasimira Aleksandrova, Robin Reichmann, Rudolf Kaaks, Mazda Jenab, H. Bas Bueno-de-Mesquita, Christina C. Dahm, Anne Kirstine Eriksen, Anne Tjønneland, Fanny Artaud, Marie-Christine Boutron-Ruault, Gianluca Severi, Anika Hüsing, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Salvatore Panico…
    Citation: BMC Medicine 2021 19:1
  23. Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adi...

    Authors: Caroline J. Bull, Joshua A. Bell, Neil Murphy, Eleanor Sanderson, George Davey Smith, Nicholas J. Timpson, Barbara L. Banbury, Demetrius Albanes, Sonja I. Berndt, Stéphane Bézieau, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Andrea Burnett-Hartman, Graham Casey, Sergi Castellví-Bel…
    Citation: BMC Medicine 2020 18:396
  24. Clinical studies indicate chemotherapy agents used in childhood cancer treatment regimens may impact future fertility. However, effects of individual agents on prepubertal human testis, necessary to identify l...

    Authors: Melissa D. Tharmalingam, Gabriele Matilionyte, William H. B. Wallace, Jan-Bernd Stukenborg, Kirsi Jahnukainen, Elizabeth Oliver, Anne Goriely, Sheila Lane, Jingtao Guo, Bradley Cairns, Anne Jorgensen, Caroline M. Allen, Federica Lopes, Richard A. Anderson, Norah Spears and Rod T. Mitchell
    Citation: BMC Medicine 2020 18:374
  25. Improved survival means that cancer is increasingly becoming a chronic disease. Understanding and improving functional outcomes are critical to optimising survivorship. We quantified physical and mental health...

    Authors: Grace Joshy, Joanne Thandrayen, Bogda Koczwara, Phyllis Butow, Rebekah Laidsaar-Powell, Nicole Rankin, Karen Canfell, John Stubbs, Paul Grogan, Louise Bailey, Amelia Yazidjoglou and Emily Banks
    Citation: BMC Medicine 2020 18:372
  26. Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potent...

    Authors: Maria Escala-Garcia, Anna Morra, Sander Canisius, Jenny Chang-Claude, Siddhartha Kar, Wei Zheng, Stig E. Bojesen, Doug Easton, Paul D. P. Pharoah and Marjanka K. Schmidt
    Citation: BMC Medicine 2020 18:327
  27. Malaria is associated with Burkitt lymphoma among children in Sub-Saharan Africa. No longitudinal studies have assessed the long-term risk of other lymphoma or cancer overall. Here, we investigated the risk of...

    Authors: Katja Wyss, Fredrik Granath, Andreas Wångdahl, Therese Djärv, Michael Fored, Pontus Naucler and Anna Färnert
    Citation: BMC Medicine 2020 18:296
  28. Novel biological and precision therapies and their associated predictive biomarker tests offer opportunities for increased tumor response, reduced adverse effects, and improved survival. This systematic review...

    Authors: Ruth P. Norris, Rosie Dew, Linda Sharp, Alastair Greystoke, Stephen Rice, Kristina Johnell and Adam Todd
    Citation: BMC Medicine 2020 18:282
  29. High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc...

    Authors: Salam Bashir, Leopold K. Fezeu, Shani Leviatan Ben-Arye, Sharon Yehuda, Eliran Moshe Reuven, Fabien Szabo de Edelenyi, Imen Fellah-Hebia, Thierry Le Tourneau, Berthe Marie Imbert-Marcille, Emmanuel B. Drouet, Mathilde Touvier, Jean-Christian Roussel, Hai Yu, Xi Chen, Serge Hercberg, Emanuele Cozzi…
    Citation: BMC Medicine 2020 18:262
  30. A national endoscopic screening program for gastric cancer was rolled out in Japan in 2015. We used a microsimulation model to estimate the cost-effectiveness of current screening guidelines and alternative sc...

    Authors: Hsi-Lan Huang, Chi Yan Leung, Eiko Saito, Kota Katanoda, Chin Hur, Chung Yin Kong, Shuhei Nomura and Kenji Shibuya
    Citation: BMC Medicine 2020 18:257
  31. Cancer patients have a highly increased risk of psychiatric disorders following diagnosis, compared with cancer-free individuals. Inflammation is involved in the development of both cancer and psychiatric diso...

    Authors: Kejia Hu, Arvid Sjölander, Donghao Lu, Adam K. Walker, Erica K. Sloan, Katja Fall, Unnur Valdimarsdóttir, Per Hall, Karin E. Smedby and Fang Fang
    Citation: BMC Medicine 2020 18:238
  32. Despite the biological link between thyroid hormones and breast cancer cell proliferation shown in experimental studies, little is known about the association between hyperthyroidism and breast cancer, as well...

    Authors: Haomin Yang, Natalie Holowko, Felix Grassmann, Mikael Eriksson, Per Hall and Kamila Czene
    Citation: BMC Medicine 2020 18:225
  33. Hitherto only studies with selected populations have found an increased all-cause mortality of some selected opioids compared to selected non-opioids for chronic non-cancer pain (CNCP). We have examined the al...

    Authors: Winfried Häuser, Tino Schubert, Tobias Vogelmann, Christoph Maier, Mary-Ann Fitzcharles and Thomas Tölle
    Citation: BMC Medicine 2020 18:162
  34. Children with cancer experience impaired cardiorespiratory fitness and physical function during and after treatment restricting their possibilities to engage in social activities including sport, leisure activ...

    Authors: Martin Kaj Fridh Nielsen, Jesper Frank Christensen, Thomas Leth Frandsen, Troels Thorsteinsson, Lars Bo Andersen, Karl Bang Christensen, Peder Skov Wehner, Henrik Hasle, Lis Ørgaard Adamsen, Kjeld Schmiegelow and Hanne Bækgaard Larsen
    Citation: BMC Medicine 2020 18:175
  35. The clinical pathway to detect and diagnose prostate cancer has been revolutionised by the use of multiparametric MRI (mpMRI pre-biopsy). mpMRI however remains a resource-intensive test and is highly operator ...

    Authors: Lois Kim, Nicholas Boxall, Anne George, Keith Burling, Pete Acher, Jonathan Aning, Stuart McCracken, Toby Page and Vincent J. Gnanapragasam
    Citation: BMC Medicine 2020 18:95
  36. Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely inv...

    Authors: Heinz Freisling, Vivian Viallon, Hannah Lennon, Vincenzo Bagnardi, Cristian Ricci, Adam S. Butterworth, Michael Sweeting, David Muller, Isabelle Romieu, Pauline Bazelle, Marina Kvaskoff, Patrick Arveux, Gianluca Severi, Christina Bamia, Tilman Kühn, Rudolf Kaaks…
    Citation: BMC Medicine 2020 18:5
  37. Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some establis...

    Authors: Nena Karavasiloglou, Anika Hüsing, Giovanna Masala, Carla H. van Gils, Renée Turzanski Fortner, Jenny Chang-Claude, Inge Huybrechts, Elisabete Weiderpass, Marc Gunter, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Anne Tjønneland, Cecilie Kyrø, Christina C. Dahm, Helene Tilma Vistisen…
    Citation: BMC Medicine 2019 17:221
  38. Although long-term alcohol and tobacco use have widely been recognised as important risk factors for cancer, the impacts of alcohol and tobacco health policies on cancer mortality have not been examined in pre...

    Authors: Heng Jiang, Michael Livingston, Robin Room, Yong Gan, Dallas English and Richard Chenhall
    Citation: BMC Medicine 2019 17:213
  39. Studies have suggested sex differences in the mortality rate associated with diabetes. We conducted a meta-analysis to estimate the relative effect of diabetes on the risk of all-cause, cancer, cardiovascular ...

    Authors: Yafeng Wang, Adrienne O’Neil, Yurui Jiao, Lijun Wang, Jingxin Huang, Yutao Lan, Yikun Zhu and Chuanhua Yu
    Citation: BMC Medicine 2019 17:136
  40. Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Here we used healthcare records of 18 m...

    Authors: Myriam Alexander, A. Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M. Waterworth, Stuart Kendrick, Naveed Sattar and William Alazawi
    Citation: BMC Medicine 2019 17:95

    The Commentary to this article has been published in BMC Medicine 2019 17:123