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Wiring the brain

Wiring the brain is a series of articles aimed at exploring how brain connectivity is established, what happens to circuit and network function when the underlying processes go wrong, and how this can lead to psychiatric and neurological disease. Articles will also cover key issues in brain research, from the suitability of our model organisms to the impact of technological advances.

  1. Research article

    Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

    Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism. Included among...

    Claude M Schofield, Ruby Hsu, Alison J Barker, Caitlyn C Gertz, Robert Blelloch and Erik M Ullian

    Neural Development 2011 6:11

    Published on: 5 April 2011

  2. Research

    A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

    Genome-wide Association Studies (GWAS) have proved invaluable for the identification of disease susceptibility genes. However, the prioritization of candidate genes and regions for follow-up studies often prov...

    John P Hussman, Ren-Hua Chung, Anthony J Griswold, James M Jaworski, Daria Salyakina, Deqiong Ma, Ioanna Konidari, Patrice L Whitehead, Jeffery M Vance, Eden R Martin, Michael L Cuccaro, John R Gilbert, Jonathan L Haines and Margaret A Pericak-Vance

    Molecular Autism 2011 2:1

    Published on: 19 January 2011

  3. Research article

    A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype

    The dorsal thalamus acts as a gateway and modulator for information going to and from the cerebral cortex. This activity requires the formation of reciprocal topographic axon connections between thalamus and c...

    Noelle D Dwyer, Danielle K Manning, Jennifer L Moran, Raksha Mudbhary, Michael S Fleming, Carlita B Favero, Vita M Vock, Dennis DM O'Leary, Christopher A Walsh and David R Beier

    Neural Development 2011 6:3

    Published on: 7 January 2011

  4. Commentary

    Screening for genes that wire the cerebral cortex

    Thalamocortical projections convey visual, somatosensory and auditory information to the cerebral cortex. A recent report in Neural Development shows how a forward genetic screen has enabled the identification of...

    Ludmilla Lokmane and Sonia Garel

    BMC Biology 2011 9:1

    Published on: 7 January 2011

  5. Research

    Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

    SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-...

    Ozlem Bozdagi, Takeshi Sakurai, Danae Papapetrou, Xiaobin Wang, Dara L Dickstein, Nagahide Takahashi, Yuji Kajiwara, Mu Yang, Adam M Katz, Maria Luisa Scattoni, Mark J Harris, Roheeni Saxena, Jill L Silverman, Jacqueline N Crawley, Qiang Zhou, Patrick R Hof…

    Molecular Autism 2010 1:15

    Published on: 17 December 2010