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Wiring the brain

Wiring the brain is a series of articles aimed at exploring how brain connectivity is established, what happens to circuit and network function when the underlying processes go wrong, and how this can lead to psychiatric and neurological disease. Articles will also cover key issues in brain research, from the suitability of our model organisms to the impact of technological advances.

  1. Content type: Research article

    Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism. Included among...

    Authors: Claude M Schofield, Ruby Hsu, Alison J Barker, Caitlyn C Gertz, Robert Blelloch and Erik M Ullian

    Citation: Neural Development 2011 6:11

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  2. Content type: Research

    Genome-wide Association Studies (GWAS) have proved invaluable for the identification of disease susceptibility genes. However, the prioritization of candidate genes and regions for follow-up studies often prov...

    Authors: John P Hussman, Ren-Hua Chung, Anthony J Griswold, James M Jaworski, Daria Salyakina, Deqiong Ma, Ioanna Konidari, Patrice L Whitehead, Jeffery M Vance, Eden R Martin, Michael L Cuccaro, John R Gilbert, Jonathan L Haines and Margaret A Pericak-Vance

    Citation: Molecular Autism 2011 2:1

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  3. Content type: Research article

    The dorsal thalamus acts as a gateway and modulator for information going to and from the cerebral cortex. This activity requires the formation of reciprocal topographic axon connections between thalamus and c...

    Authors: Noelle D Dwyer, Danielle K Manning, Jennifer L Moran, Raksha Mudbhary, Michael S Fleming, Carlita B Favero, Vita M Vock, Dennis DM O'Leary, Christopher A Walsh and David R Beier

    Citation: Neural Development 2011 6:3

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  4. Content type: Commentary

    Thalamocortical projections convey visual, somatosensory and auditory information to the cerebral cortex. A recent report in Neural Development shows how a forward genetic screen has enabled the identification of...

    Authors: Ludmilla Lokmane and Sonia Garel

    Citation: BMC Biology 2011 9:1

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  5. Content type: Research

    SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-...

    Authors: Ozlem Bozdagi, Takeshi Sakurai, Danae Papapetrou, Xiaobin Wang, Dara L Dickstein, Nagahide Takahashi, Yuji Kajiwara, Mu Yang, Adam M Katz, Maria Luisa Scattoni, Mark J Harris, Roheeni Saxena, Jill L Silverman, Jacqueline N Crawley, Qiang Zhou, Patrick R Hof…

    Citation: Molecular Autism 2010 1:15

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