Todd Golde, Leonard Petrucelli
PrPScaccumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases
Prion diseases are disorders of protein conformation in which PrPC, the normal cellular conformer, is converted to an abnormal, protease-resistant conformer rPrPSc. Approximately 80% of rPrPSc accumulates in neur...
Citation: Molecular Neurodegeneration 2010 5:6