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What kills neurons in neurodegenerative disease?

Todd Golde, Leonard Petrucelli

  1. Prion diseases are disorders of protein conformation in which PrPC, the normal cellular conformer, is converted to an abnormal, protease-resistant conformer rPrPSc. Approximately 80% of rPrPSc accumulates in neur...

    Authors: Stephen J DeArmond and Krystyna Bajsarowicz
    Citation: Molecular Neurodegeneration 2010 5:6
  2. Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed t...

    Authors: Ganesh M Shankar and Dominic M Walsh
    Citation: Molecular Neurodegeneration 2009 4:48
  3. While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults. Infections, tra...

    Authors: Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine and Malú G Tansey
    Citation: Molecular Neurodegeneration 2009 4:47
  4. The nematode worm Caenorhabditis elegans has become an intensely studied model organism, and worm studies have made significant contributions to developmental biology and other fields. The experimental advantages...

    Authors: Dawn Teschendorf and Christopher D Link
    Citation: Molecular Neurodegeneration 2009 4:38
  5. While numerous hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of neurodegenerative diseases, the theory of oxidative stress has received considerable support. Alt...

    Authors: Kristen A Malkus, Elpida Tsika and Harry Ischiropoulos
    Citation: Molecular Neurodegeneration 2009 4:24
  6. Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication and adhesion. The exact definition at the molecular...

    Authors: Philippe Marambaud, Ute Dreses-Werringloer and Valérie Vingtdeux
    Citation: Molecular Neurodegeneration 2009 4:20
  7. Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's disease and related tauopathies, and the discovery that mutations in the tau gene cause frontotemporal dementia, ...

    Authors: Tania F Gendron and Leonard Petrucelli
    Citation: Molecular Neurodegeneration 2009 4:13
  8. α-Synuclein is a small protein that has special relevance for understanding Parkinson disease and related disorders. Not only is α-synuclein found in Lewy bodies characteristic of Parkinson disease, but also m...

    Authors: Mark R Cookson
    Citation: Molecular Neurodegeneration 2009 4:9