World AIDS Day 2013 – Invited Articles for AIDS Research and Therapy

Antiretroviral regimens sparing agents from the nucleoside(tide) reverse transcriptase inhibitor class: a review of the recent literature

The nucleoside(tide) reverse transcriptase inhibitors (NRTIs) have traditionally been an important ‘back-bone’ of an antiretroviral therapy (ART) regimen. However all agents have been associated with both shor...

Authors: Amit C Achhra and Mark A Boyd

Metabolic syndrome in HIV-infected individuals: underlying mechanisms and epidemiological aspects

The success of highly active antiretroviral therapy (HAART) has determined a dramatic decline in AIDS- and immunodeficiency-related causes of death in the HIV-infected population. As life-expectancy increases,...

Authors: Adelzon A Paula, Melissa CN Falcão and Antonio G Pacheco

Putting an ‘End’ to HIV mRNAs: capping and polyadenylation as potential therapeutic targets

Like most cellular mRNAs, the 5′ end of HIV mRNAs is capped and the 3′ end matured by the process of polyadenylation. There are, however, several rather unique and interesting aspects of these post-transcripti...

Authors: Jeffrey Wilusz

Women and HIV in Sub-Saharan Africa

Thirty years since the discovery of HIV, the HIV pandemic in sub-Saharan Africa accounts for more than two thirds of the world’s HIV infections. Southern Africa remains the region most severely affected by the...

Authors: Gita Ramjee and Brodie Daniels

Serious Non-AIDS events: Immunopathogenesis and interventional strategies

Despite the major advances in the management of HIV infection, HIV-infected patients still have greater morbidity and mortality than the general population. Serious non-AIDS events (SNAEs), including non-AIDS ...

Authors: Denise C Hsu, Irini Sereti and Jintanat Ananworanich

World AIDS Day Commemoration

Authors: Kailash Gupta