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Virtual Slides

Now you can include virtual slides into your article. These will be administered by DiagnomX, scanned and hosted by Huron Technologies International, Inc, Canada, Leica Microsystems, Germany, or Motic Medical Diagnostic Systems, China. The slides will be displayed with an easy to use viewing tool and an individual image data bank for your own use. If you wish to include virtual slides in your manuscript please indicate this in your cover letter on submission, and for an example of a virtual slide please see here.

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  1. Research

    Metaplastic carcinoma of the breast: an immunohistochemical study

    Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of me...

    Fadwa J Altaf, Ghadeer A Mokhtar, Eman Emam, Rana Y Bokhary, Najlaa Bin Mahfouz, Samia Al Amoudi and Zuhoor K AL-Gaithy

    Diagnostic Pathology 2014 9:139

    Published on: 16 July 2014

  2. Research

    Heterogenous mismatch-repair status in colorectal cancer

    Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify mismatch repair defective tumors. The tumors typically show uniform and widespread loss of MMR protein stainin...

    Patrick Joost, Nynke Veurink, Susanne Holck, Louise Klarskov, Anders Bojesen, Maria Harbo, Bo Baldetorp, Eva Rambech and Mef Nilbert

    Diagnostic Pathology 2014 9:126

    Published on: 26 June 2014

  3. Letter to the Editor

    Significance of 18 F-FDG PET and immunohistochemical GLUT-1 expression for cardiac myxoma

    Cardiac tumours are relatively rare and are difficult to diagnose merely with imaging techniques. We demonstrated an unusual case of left atrial myxoma, displaying the successful detection by positron emission...

    Yukio Okazaki, Sohsuke Yamada, Shohei Kitada, Iwao Matsunaga, Eijirou Nogami, Teruo Watanabe, Yasuyuki Sasaguri, Yutaka Honma and Tsuyoshi Itou

    Diagnostic Pathology 2014 9:117

    Published on: 16 June 2014

  4. Research

    Quantification of myocardial fibrosis by digital image analysis and interactive stereology

    Cardiac fibrosis disrupts the normal myocardial structure and has a direct impact on heart function and survival. Despite already available digital methods, the pathologist’s visual score is still widely consi...

    Dainius Daunoravicius, Justinas Besusparis, Edvardas Zurauskas, Aida Laurinaviciene, Daiva Bironaite, Sabine Pankuweit, Benoit Plancoulaine, Paulette Herlin, Julius Bogomolovas, Virginija Grabauskiene and Arvydas Laurinavicius

    Diagnostic Pathology 2014 9:114

    Published on: 9 June 2014

  5. Case Report

    Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

    Adult testicular granulosa cell tumors are rare sex cord- stromal tumors of which only 45 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive c...

    Thomas EO Schubert, Robert Stoehr, Arndt Hartmann, Sabrina Schöne, Mathias Löbelenz and Gregor Mikuz

    Diagnostic Pathology 2014 9:107

    Published on: 3 June 2014

  6. Short report

    Adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of spermatic cord leiomyosarcoma

    The aim of this report is related to adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of the spermatic cord leiomyosarcoma. Primary paratesticular tumors are ...

    Andrea B Galosi, Marina Scarpelli, Roberta Mazzucchelli, Antonio Lopez-Beltran, Lucio Giustini, Liang Cheng and Rodolfo Montironi

    Diagnostic Pathology 2014 9:90

    Published on: 6 May 2014

  7. Letter to the Editor

    Immunohistochemical analysis of PDK1 expression in breast cancer

    3-phosphoinositide-dependent protein kinase-1 (PDK1) functions downstream of phosphoinositide 3-kinase (PIK3) and activates members of the AGC family of protein kinases that are known to play crucial roles in ...

    Ruza Arsenic

    Diagnostic Pathology 2014 9:82

    Published on: 16 April 2014

  8. Research

    Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer

    Hamartin (TSC1) and tuberin (TSC2), encoded by the tuberous sclerosis complex (TSC) genes, form a tumor-suppressor heterodimer which is implicated in PI3K-Akt signaling and acts as a functional inhibitor of the m...

    Angela Fuchs, Katharina König, Lukas C Heukamp, Jana Fassunke, Jutta Kirfel, Sebastian Huss, Albert J Becker, Reinhard Büttner and Michael Majores

    Diagnostic Pathology 2014 9:48

    Published on: 4 March 2014

  9. Case Report

    Case report: intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype

    Intraductal tubulopapillary neoplasms of the pancreas are very rare tumors characterized by intraductal tubulopapillary growth, ductal differentiation, scant intracellular mucin production and cellular dysplas...

    Maria Gabriele Ahls, Marco Niedergethmann, Dietmar Dinter, Christian Sauer, Jutta Lüttges, Stefan Post, Alexander Marx and Timo Gaiser

    Diagnostic Pathology 2014 9:11

    Published on: 20 January 2014

  10. Case Report

    Diffuse panbronchiolitis in a patient with common variable immunodeficiency: a casual association or a pathogenetic correlation?

    Diffuse panbronchiolitis (DPB) is an idiopathic inflammatory disease that seems to have an immunological pathogenesis and that causes a severe progressive suppurative and obstructive respiratory disorder. Comm...

    Alessandro Ginori, Aurora Barone, David Bennett, Marie Aimée Gloria Munezero Butorano, Maria Grazia Mastrogiulio, Antonella Fossi, Paola Rottoli and Donatella Spina

    Diagnostic Pathology 2014 9:12

    Published on: 20 January 2014

  11. Research

    Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors

    Protein arginine methyltransferase-5 (PRMT5) is a chromatin-modifying enzyme capable of methylating histone and non-histone proteins, and is involved in a wide range of cellular processes that range from trans...

    Konstantin Shilo, Xin Wu, Smita Sharma, Meng Welliver, Wenrui Duan, Miguel Villalona-Calero, Junya Fukuoka, Said Sif, Robert Baiocchi, Charles L Hitchcock, Weiqiang Zhao and Gregory A Otterson

    Diagnostic Pathology 2013 8:201

    Published on: 10 December 2013

  12. Case Report

    Cystic endosalpingiosis presenting as chronic back pain, a case report

    A 48-year old woman presented with chronic back pain. Previous examinations had been inconclusive. Gynaecological examination revealed large cystic masses on the fundus uteri and left adnexa. Laparoscopy and h...

    Andreas H Scheel, Josef Frasunek, Werner Meyer and Philipp Ströbel

    Diagnostic Pathology 2013 8:196

    Published on: 3 December 2013

  13. Review

    Extrapelvic endometriosis: a rare entity or an under diagnosed condition?

    Endometriosis is a clinical entity characterized by the presence of normal endometrial mucosa abnormally implanted in locations other than the uterine cavity. Endometriosis can be either endopelvic or extrapel...

    Nikolaos Machairiotis, Aikaterini Stylianaki, Georgios Dryllis, Paul Zarogoulidis, Paraskevi Kouroutou, Nikolaos Tsiamis, Nikolaos Katsikogiannis, Eirini Sarika, Nikolaos Courcoutsakis, Theodora Tsiouda, Andreas Gschwendtner, Konstantinos Zarogoulidis, Leonidas Sakkas, Aggeliki Baliaka and Christodoulos Machairiotis

    Diagnostic Pathology 2013 8:194

    Published on: 2 December 2013

  14. Case Report

    Ectopic pancreatic pseudocyst and cyst presenting as a cervical and mediastinal mass - case report and review of the literature

    Ectopic pancreas in the mediastinum is extremely rare. We are reporting on a case of a twenty two year old woman who presented to our clinic with a large cervical mass. The CT scan revealed a cystic lesion in ...

    Ariel Rokach, Gabriel Izbicki, Maher Deeb, Naama Bogot, Nissim Arish, Irith Hadas-Halperen, Hava Azulai, Abraham Bohadana and Eli Golomb

    Diagnostic Pathology 2013 8:176

    Published on: 23 October 2013

  15. Letter to the Editor

    Benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma arising from the nose

    Very recently, Requena et al. have demonstrated the detailed clinicopathological features of 9 cases of a benign cutaneous plexiform nerve sheath tumor with hybrid characteristics of perineurioma and cellular neu...

    Sohsuke Yamada, Shohei Kitada, Atsunori Nabeshima, Hirotsugu Noguchi, Yasuyuki Sasaguri and Masanori Hisaoka

    Diagnostic Pathology 2013 8:165

    Published on: 8 October 2013

  16. Case Report

    Mixed neuronal-glial tumor in the temporal lobe of an infant: a case report

    Tumors that arise in the temporal lobes of infants and spread to the neural system are limited to several diagnoses. Herein, we present an infantile case of a temporal tumor showing neuronal and glial differen...

    Hirohito Yano, Chiemi Saigoh, Noriyuki Nakayama, Yoshinobu Hirose, Masato Abe, Naoyuki Ohe, Michio Ozeki, Jun Shinoda and Toru Iwama

    Diagnostic Pathology 2013 8:164

    Published on: 2 October 2013

  17. Case Report

    Case report: Papillary mesothelioma of the peritoneum with foamy cell lining

    A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary...

    Simona Stolnicu, Enoe Quiñonez, Monica Boros, Claudiu Molnar, Isabel Dulcey and Francisco F Nogales

    Diagnostic Pathology 2013 8:162

    Published on: 25 September 2013

  18. Case Report

    Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman

    A 36-year-old female was hospitalized with symptoms suggesting intestinal occlusion. She was diagnosed with adenocarcinoma of the ampulla of Vater (pT4N0 stage) and underwent cephalic duodenopancreatectomy 8 m...

    Simona Gurzu, Ioan Jung, Maria Comsulea, Zoltan Kadar, Leonard Azamfirei and Calin Molnar

    Diagnostic Pathology 2013 8:150

    Published on: 16 September 2013

  19. Case Report

    Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile

    Intestinal differentiation in the endometrium is rare with only case reports in the international literature. We describe a case of simultaneous endocervical and intestinal-type mucinous differentiation with g...

    Rebecca Buell-Gutbrod, C James Sung, W Dwayne Lawrence and M Ruhul Quddus

    Diagnostic Pathology 2013 8:128

    Published on: 2 August 2013

  20. Case Report

    Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

    Lymphomas account for less than 5% of thyroid malignant lesions. Vast majority of them are B-cell non-Hodgkin lymphomas (NHL), while Hodgkin lymphoma (HL) is extremely rare. Here we present two cases of HL, at...

    Ewelina Szczepanek-Parulska, Malgorzata Szkudlarek, Przemyslaw Majewski, Jan Breborowicz and Marek Ruchala

    Diagnostic Pathology 2013 8:116

    Published on: 15 July 2013

  21. Research

    Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma

    The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization. The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in h...

    Antonio Zizzi, Maria Alessandra Montironi, Roberta Mazzucchelli, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Nicola Paone, Paolo Castellini and Rodolfo Montironi

    Diagnostic Pathology 2013 8:111

    Published on: 2 July 2013

  22. Case Report

    Isolated hypoplastic circumflex coronary artery: a rare cause of haemorrhagic myocardial infarction in a young athlete

    Hypoplastic coronary artery disease is a rare condition that may lead to myocardial infarction and sudden death. Here we describe for the first time an isolated hypoplasia of the left circumflex artery (LCX). ...

    Florian-Nikolaus Riede, Stefan Bulla, Sebastian Grundmann, Martin Werner, Urs-Nikolaus Riede and Claudia Otto

    Diagnostic Pathology 2013 8:91

    Published on: 6 June 2013

  23. Case Report

    Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC

    A mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nu...

    Sohsuke Yamada, Atsunori Nabeshima, Yoshika Nagata, Takashi Tasaki, Hirotsugu Noguchi, Shohei Kitada, Satoshi Kimura, Ke-Yong Wang, Shohei Shimajiri and Yasuyuki Sasaguri

    Diagnostic Pathology 2013 8:75

    Published on: 7 May 2013

  24. Case Report

    Primary angiosarcoma of the breast: a case report

    Primary angiosarcoma of the breast is extremely rare. Radiologic findings are often non specific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor ...

    Amal Bennani, Layla Chbani, Meryem Lamchahab, Mouhcine Wahbi, Fatimazzahra Fdili Alaoui, Ikram Badioui, Moulay Abdelilah Melhouf and Affaf Amarti

    Diagnostic Pathology 2013 8:66

    Published on: 22 April 2013

  25. Research

    Validation of various adaptive threshold methods of segmentation applied to follicular lymphoma digital images stained with 3,3’-Diaminobenzidine&Haematoxylin

    The comparative study of the results of various segmentation methods for the digital images of the follicular lymphoma cancer tissue section is described in this paper. The sensitivity and specificity and some...

    Anna Korzynska, Lukasz Roszkowiak, Carlos Lopez, Ramon Bosch, Lukasz Witkowski and Marylene Lejeune

    Diagnostic Pathology 2013 8:48

    Published on: 25 March 2013

  26. Research

    P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas

    We investigated the immunohistochemical expression of p53, MAPK, topoisomerase II alpha (topoII alpha) and Ki67 in ovarian serous carcinomas (OSCs) along with mutational analysis for KRAS and BRAF.

    Dinka Sundov, Ana Caric, Ivana Mrklic, Dijana Gugic, Vesna Capkun, Irena Drmic Hofman, Branka Petric Mise and Snjezana Tomic

    Diagnostic Pathology 2013 8:21

    Published on: 6 February 2013

  27. Case Report

    A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature

    Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case...

    Merieme Ghaouti, Kaoutar Znati, Ahmed Jahid, Fouad Zouaidia, Zakiya Bernoussi, Youssef El Fakir and Najat Mahassini

    Diagnostic Pathology 2013 8:4

    Published on: 10 January 2013

  28. Case Report

    Paediatric T-cell lymphoma of the appendix: a case report

    A 7-year-old boy with no history of malnutrition or diarrhoea complained of acute abdominal pain, was diagnosed with acute appendicitis, and underwent appendectomy. Histologically, a diffuse infiltrate of larg...

    Yoshifumi Matsushita and Morishige Takeshita

    Diagnostic Pathology 2013 8:2

    Published on: 9 January 2013

  29. Case Report

    Prostatic stromal sarcoma with neuroectodermal differentiation

    Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1–0.2% of all prostatic cancers. Detailed characteristics of the tumor are still unclear due to its rarity.

    Hitoshi Yamazaki, Teppei Ohyama, Toshiki Tsuboi, Yoshinori Taoka, Dai Kohguchi, Hiroyoshi Iguchi and Teruaki Ao

    Diagnostic Pathology 2012 7:173

    Published on: 7 December 2012

  30. Research

    IMP3 can predict aggressive behaviour of lung adenocarcinoma

    Lung cancer most often presents as an inoperable tumour and the diagnosis is usually performed on a small biopsy/cytology specimen. In the group of non small cell lung cancer - not otherwise specified, adenoca...

    Renata Beljan Perak, Merica Glavina Durdov, Vesna Capkun, Veljka Ivcevic, Antonia Pavlovic, Violeta Soljic and Mari Peric

    Diagnostic Pathology 2012 7:165

    Published on: 28 November 2012

  31. Short report

    Molecular modeling and description of a newly characterized activating mutation of the EGFR gene in non-small cell lung cancer

    Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promi...

    Claudia Otto, Agnes Csanadi, Paul Fisch, Martin Werner and Gian Kayser

    Diagnostic Pathology 2012 7:146

    Published on: 22 October 2012

  32. Case Report

    Primary splenic histiocytic sarcoma complicated with prolonged idiopathic thrombocytopenia and secondary bone marrow involvement: a unique surgical case presenting with splenomegaly but non-nodular lesions

    A 67-year-old Japanese female was followed up due to prolonged idiopathic thrombocytopenia with non-response to steroid therapy for 4 years, but recent progressive pancytopenia, hypo-albuminemia, and hypo-γ-gl...

    Sohsuke Yamada, Takashi Tasakil, Naoko Satoh, Atsunori Nabeshima, Shohei Kitada, Hirotsugu Noguchi, Kozue Yamada, Morishige Takeshita and Yasuyuki Sasaguri

    Diagnostic Pathology 2012 7:143

    Published on: 17 October 2012

  33. Case Report

    Primary mucinous cystadenoma of the spermatic cord within the inguinal canal

    We report a hitherto not documented case of primary mucinous cystadenoma arising in the spermatic cord within the right inguinal canal of a78-year-old man. The tumor was painless, hard and mobile. A computed t...

    Jee-Yeon Kim, Young-Taek Lee, Hyun-Jeong Kang and Chang-Hun Lee

    Diagnostic Pathology 2012 7:139

    Published on: 8 October 2012

  34. Case Report

    CD20-positive NK/T-cell lymphoma with indolent clinical course: report of case and review of literature

    CD20-positive T-cell lymphoma is extremely rare and only two cases of CD20-positive NK/T-cell lymphoma with aggressive clinical courses have been described in the literature. We present a case of unusual NK/T-...

    Qing-ping Jiang, Shao-yan Liu, Yue-xin Yang, Xue-xian Tan, Juan Peng, Zhong-tang Xiong and Zhi Li

    Diagnostic Pathology 2012 7:133

    Published on: 2 October 2012

  35. Research

    Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience

    Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of lim...

    Nawal Hammas, Chbani Laila, Alaoui Lamrani My Youssef, El Fatemi Hind, Taoufiq Harmouch, Tizniti Siham and Amarti Afaf

    Diagnostic Pathology 2012 7:130

    Published on: 27 September 2012

  36. Case Report

    Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression

    Langerhans cell sarcoma is a rare and aggressive high grade hematopoietic neoplasm with a dismal prognosis. It has a unique morphological and immunotypic profile with a CD1a/ langerin/S100 + phenotype. T cell ...

    Zhaodong Xu, Ruth Padmore, Carolyn Faught, Lisa Duffet and Bruce F Burns

    Diagnostic Pathology 2012 7:128

    Published on: 25 September 2012

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