Edited by:
Andy T. Y. Lau, PhD, Shantou University Medical College, China
Amy Yan-Ming Xu, PhD, Shantou University Medical College, China
Cancer Cell International is presenting the Collection on 'Ubiquitin Biology and Human Health.' The aim of this collection is to gather the latest knowledge and perspectives regarding ubiquitin research.
This is an invite-only collection.
Clinical trials and studies have implicated that E3 ubiquitin ligase BTBD3 (BTB Domain Containing 3) is a cancer-associated gene. However, the role and underlying mechanism of BTBD3 in colorectal cancer (CRC) ...
Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific peptidase 8 (USP8) as a key regulator for promoting the tumo...
Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanisms. Recent evidence shows that the ubiquitin-protease system is closely related to TNBC...
Globally, breast cancer in women is the fifth leading cause of cancer death. There is an urgent need to explore the molecular mechanism of breast cancer proliferation and metastasis.
Gastric cancer is a highly prevalent cancer type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several type...
Bladder cancer is the second most common genitourinary malignancy worldwide. The death rate of bladder cancer has increased every year. However, the molecular mechanism of bladder cancer is not sufficiently st...
Myosin heavy chain 9 (MYH9) plays an important role in a number of diseases. Nevertheless, the function of MYH9 in glioma is unclear. The present research aimed to investigate the role of MYH9 in glioma and de...
Deubiquitinating enzymes (DUBs) comprise a family of proteases responsible for cleaving the peptide or isopeptide bond between ubiquitin and its substrate proteins. Ubiquitin is essential for regulating divers...
Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiqu...
Cancer Cell International is presenting the Collection on 'Ubiquitin Biology and Human Health.'
What makes ubiquitin biology so exciting and fascinating within biomedical science in the past few decades are the biochemical behaviors that allow ubiquitylation/deubiquitylation to modulate diverse processes of life. The growing lists of ubiquitin linkage types (monoubiquitylation, multi-monoubiquitylation, or homotypic/heterotypic polyubiquitylation), ubiquitin conjugation systems, and deubiquitylation enzymes have driven the curiosity of scientists to gradually reveal the complex realm between ubiquitin machinery and its dysregulation in various human diseases including cancer.
This year marks the 19th anniversary of the Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. We are honored to have the first kickoff article in this thematic series by Professor Aaron Ciechanover, Nobel Prize laureate in Chemistry of 2004. This collection will also comprise articles from other scientists of the field; the goal is to gather the latest knowledge and perspectives regarding ubiquitin research.
This is an invite-only collection.
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