Skip to main content

Thiol-based Redox Regulation of Thrombosis

Edited by:
Yi Wu, MD, PhD, Soochow University, China

Submission Status: Open   |   Submission Deadline: 16 December 2024

Thrombosis Journal is calling for submissions to our Collection on Thiol-based Redox Regulation of Thrombosis. Redox balance lies at the core of cellular and systems homeostasis and is maintained by a network of intertwined pathways. Recently, an accumulating body of evidence suggests that thrombosis is controlled by thiol-based redox balance. Therefore, studies in this field are greatly needed for the enlightening the potential mechanisms behind thrombosis and the practical value for clinical application.

Image credits: © Axel Kock /

New Content ItemThis collection supports and amplifies research related to SDG 3: Good health and well-being.

About the Collection

Thrombosis Journal is calling for submissions to our Collection on Thiol-based Redox Regulation of Thrombosis. Thrombosis is currently the leading cause of death in many diseased conditions; however, its mechanism remains largely elusive. It has been known that thiol-disulfide exchange dramatically and quickly change the function of critical hemostatic proteins, such as platelet GPIb, integrins aIIbb3 and a2b1, tissue factor, coagulation factor XI, fibrinogen, von Willebrand factor, histidine-rich glycoprotein, and thrombospondin etc. Therefore, it is important to understand the enzymes that regulates these dynamic thiol-based post-translational modifications. Recent studies show several thiol oxidoreductases including PDI, ERp5, ERp57, ERp46, ERp72 support thrombosis, but TMX1 has an inhibitory role, demonstrating that prothrombotic and antithrombotic thiol isomerases are central elements of redox balance controlling thrombosis.  However, we are in the early stages of our investigation of the complex regulation, and many outstanding questions still remain: Do other thiol oxidoreductases contribute to thrombosis? What are their substrates and targeting cysteine/disulfides? Do they function in parallel or cooperatively? Whether and how do they contribute to the pathogenesis of thrombotic diseases? This collection aims to gather contributions that enhance our knowledge on these topics that may include:

• Identification of new thiol oxidoreductases in positive and negative regulation of platelet, coagulation and anti-coagulation factors, fibrinolytic enzymes, and other plasma and matrix proteins, as well as the interaction and cross-talks of thiol oxidoreductases.

• Thiol-based integration mechanism of platelet activation and coagulation system, for initiation, propagation and self-limitation of thrombosis.

• New chemical tools and methodology development to evaluate redox state of thiol oxidoreductases and their targeting substrates and cysteines/disulfides in vivo and in vitro.

• Thiol oxidoreductases as therapeutic target for thrombotic diseases.

There are currently no articles in this collection.

Submission Guidelines

Back to top

This Collection welcomes submission of Research Articles, Reviews, Experimental Protocols, and Database Articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Thiol-based Redox Regulation of Thrombosis" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.