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Treatment outcomes and paving the way for an HIV cure in Low and Middle Income Countries

Thematic Series

This AIDS Research and Therapy thematic series, edited by Dr Eric Arts, Dr Nicaise Ndembi and Dr Denis Tebit, covers the ways treatment outcomes can be improved along the way to a HIV cure in states defined as low and middle income countries (LMICs) by the WHO.

Discussion of HIV treatment outcomes in LMICs has historically been neglected, even though it is in these countries that a cure is most crucial. Of course, a cure for any HIV infected individual is equally critical but as many of you are witnessing, even a low rate of first line treatment failures in LIMCs has a devastating impact for the long term outcome of these patient,s as well as the efficacy of first line treatments in newly infected, naive patients.

Treatment failure also presents an incredible burden - financially and in human terms - on the health care infrastructure in LIMCs. There are currently over 22 million people  on treatment, without a significant decrease in new infections even though there has been a decrease in overall mortality.  In the near-medium term,  it is probable that there will soon be 40+ million on life-long treatment costing over $60 billion a year. Based on this fact alone, a cure is of significant importance in LIMC which are beholden of support from the HIC for the programs set up by PEPFAR and UNAIDS.

  1. Content type: Research

    Expanded access to antiretroviral therapy (ART) leads to improved HIV/AIDS treatment outcomes in Nigeria, however, increasing rates of loss to follow-up among those on ART is threatening optimal standard achie...

    Authors: Ahmad Aliyu, Babatunde Adelekan, Nifarta Andrew, Eunice Ekong, Stephen Dapiap, Fati Murtala-Ibrahim, Iboro Nta, Nicaise Ndembi, Charles Mensah and Patrick Dakum

    Citation: AIDS Research and Therapy 2019 16:30

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  2. Content type: Review

    As antiretroviral therapy (ART) programs expand access, there is an increase in burden to a healthcare system. These results are reduced provider-patient contact time and poor programmatic and patient outcomes...

    Authors: Ahmad Aliyu, Samer El-Kamary, Jessica Brown, Bruce Agins, Nicaise Ndembi, Gambo Aliyu, Jibreel Jumare, Babatunde Adelekan, Patrick Dakum, Alash’le Abimiku and Manhattan Charurat

    Citation: AIDS Research and Therapy 2019 16:29

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  3. Content type: Research

    A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming...

    Authors: Patrick Dakum, Monday Tola, Nta Iboro, Chukwuemeka A. Okolo, Olachi Anuforom, Christopher Chime, Sam Peters, Jibreel Jumare, Obinna Ogbanufe, Aliyu Ahmad and Nicaise Ndembi

    Citation: AIDS Research and Therapy 2019 16:27

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  4. Content type: Review

    Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over...

    Authors: Camilla Muccini, Trevor A. Crowell, Eugène Kroon, Carlo Sacdalan, Reshmie Ramautarsing, Pich Seekaew, Praphan Phanuphak, Jintanat Ananworanich, Donn J. Colby and Nittaya Phanuphak

    Citation: AIDS Research and Therapy 2019 16:25

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  5. Content type: Review

    Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, ...

    Authors: Joakim Esbjörnsson, Marianne Jansson, Sanne Jespersen, Fredrik Månsson, Bo L. Hønge, Jacob Lindman, Candida Medina, Zacarias J. da Silva, Hans Norrgren, Patrik Medstrand, Sarah L. Rowland-Jones and Christian Wejse

    Citation: AIDS Research and Therapy 2019 16:24

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  6. Content type: Review

    Brazil is a low-and-middle income country (LMIC) that, despite having a large population and continental dimensions, has been able to successfully fight HIV/AIDS through a number of governmental and societal m...

    Authors: Adele S. Benzaken, Gerson F. M. Pereira, Lendel Costa, Amilcar Tanuri, André F. Santos and Marcelo A. Soares

    Citation: AIDS Research and Therapy 2019 16:19

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  7. Content type: Research

    People living with HIV (PLHIV) constantly need to address social issues such as the cost of accessing care, stigma, and lack of social support which impacts on their level of adherence to clinic visits or anti...

    Authors: Babatunde Adelekan, Nifarta Andrew, Iboro Nta, Asabe Gomwalk, Nicaise Ndembi, Charles Mensah, Patrick Dakum and Ahmad Aliyu

    Citation: AIDS Research and Therapy 2019 16:17

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