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Treatment outcomes and paving the way for an HIV cure in Low and Middle Income Countries

Thematic Series

This AIDS Research and Therapy thematic series, edited by Dr Eric Arts, Dr Nicaise Ndembi and Dr Denis Tebit, covers the ways treatment outcomes can be improved along the way to a HIV cure in states defined as low and middle income countries (LMICs) by the WHO.

Discussion of HIV treatment outcomes in LMICs has historically been neglected, even though it is in these countries that a cure is most crucial. Of course, a cure for any HIV infected individual is equally critical but as many of you are witnessing, even a low rate of first line treatment failures in LIMCs has a devastating impact for the long term outcome of these patient,s as well as the efficacy of first line treatments in newly infected, naive patients.

Treatment failure also presents an incredible burden - financially and in human terms - on the health care infrastructure in LIMCs. There are currently over 22 million people  on treatment, without a significant decrease in new infections even though there has been a decrease in overall mortality.  In the near-medium term,  it is probable that there will soon be 40+ million on life-long treatment costing over $60 billion a year. Based on this fact alone, a cure is of significant importance in LIMC which are beholden of support from the HIC for the programs set up by PEPFAR and UNAIDS.

  1. Content type: Review

    Brazil is a low-and-middle income country (LMIC) that, despite having a large population and continental dimensions, has been able to successfully fight HIV/AIDS through a number of governmental and societal m...

    Authors: Adele S. Benzaken, Gerson F. M. Pereira, Lendel Costa, Amilcar Tanuri, André F. Santos and Marcelo A. Soares

    Citation: AIDS Research and Therapy 2019 16:19

    Published on:

  2. Content type: Research

    People living with HIV (PLHIV) constantly need to address social issues such as the cost of accessing care, stigma, and lack of social support which impacts on their level of adherence to clinic visits or anti...

    Authors: Babatunde Adelekan, Nifarta Andrew, Iboro Nta, Asabe Gomwalk, Nicaise Ndembi, Charles Mensah, Patrick Dakum and Ahmad Aliyu

    Citation: AIDS Research and Therapy 2019 16:17

    Published on: