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Translational musculoskeletal research: Bridging the gap between lab and clinic

This Collection is no longer accepting submissions.

The projected burden of musculoskeletal ailments will increase in the coming decades as humans live longer. Treatment advances are needed to improve care, so more patients receive a higher quality of life for longer. The valley of death has prospered for too long with lab research failing to transition into the clinic. Limited funding in start-ups has augmented this problem in musculoskeletal science, yet translational research offers true hope in closing the gap between lab and clinic.

BMC Musculoskeletal Disorders wanted to give attention to this topic. Our journal wanted to focus on what successes and challenges potential musculoskeletal therapeutics are facing, so they eventually benefit patients and community health.

We welcomed Research Articles, Case Reports, and Study Protocols on all investigations endeavoring to progress from bench to bedside, such as lab- or simulation-based research, digitalization of biomechanics, medical code, rehabilitation devices, safety studies, research and development and/or clinical trials. Developing treatment protocols or frameworks, established in western culture /high-income countries, for adaption in other socioeconomic/ low-income settings were also encouraged to submit.

Submissions focusing on a rheumatic condition, not the joint/musculoskeletal aspect, were considered but may have been transferred to BMC Rheumatology pre-acceptance.

Meet the Collection Editors

Dr Ara Nazarian
Principal Investigator Ara Nazarian’s primary focus is on translational studies at Harvard Medical School, where we can identify an unmet clinical need and set out to find appropriate solutions. Relying on my biomechanics, bioimaging and animal models expertise, Ara has forged partnerships with clinical and research collaborators to establish a cohesive and results oriented network. Specialties: Orthopedic Biomechanics and bioimaging, mechanobiology, animal models of disease and intervention, project and personnel management. Together, we have produced a body of work, consisting of over 150 peer-reviewed publications, 2 books, more than 15 patents and patent applications, 5 startups and over 200 abstracts and conference proceedings. Ara have been Editorially involved with BMC Musculoskeletal Disorders since 2019.

Dr Biao Wang
Dr Biao Wang works in the spine department of Honghui Hospital, as a doctoral supervisor of Xi'an Jiaotong University. He is a standing member of the Shaanxi Committee of Orthopaedics Professional Committee of Chinese Medical Education Association. In recent years, 45 SCI papers have been published, including 28 by the first author or correspondent, and 17 speeches at NASS, Euro Spine and SICOT conferences in the past four years. Dr Biao Wang has won the Best Paper Award for Spinal Minimally Invasive Papers at the 2015 and 2018 NASS Annual Conferences. At present, he has presided over one project of the National Natural Fund (81802167), one project of the Xi'an Science and Technology Bureau, and participated in four scientific research projects at the national, provincial and municipal levels.

Dr Imran Khan Niazi 
Dr Imran Khan Niazi has been working for the past 12 years as an active researcher in physical and neural rehabilitation, focusing on non-pharmacological/conservative modes of treatment to optimize the patient's rehabilitation journey and improve their quality of life. He has extensive experience working in multidisciplinary teams that include chiropractors, physiotherapists, medical doctors, engineers, and neuroscientists, with a strong patient-centered, evidence-informed approach. For further details please visit Imran’s ResearchGate or Google Scholar profile.

Dr Mattia Loppini
Dr Mattia Loppini is an orthopedic and trauma consultant working since 2015 in the Hip Diseases and Joint Replacement Surgery Unit at Humanitas Research Hospital in Rozzano, Milan. Mattia was appointed Assistant Professor of Locomotor Apparatus Disease and Physical and Rehabilitative Medicine at Humanitas University in 2017. Since 2018, he also serves as Scientific Director at the “Livio Sciutto Foundation”, a non-profit organization aiming to foster research and support education in the field of hip diseases and joint replacement. Since 2022, he is a standing member of the Education Committee of European Hip Society. Moreover, he is the author of over 90 peer-reviewed publications. Mattia strongly believes in the importance of scientific research in the orthopedic field, and he means it as a duty to move forward clinical practice and ensure the best care for patients. At the same time, Mattia totally recognizes the value of a high-level training of young orthopedics, or soon to be, and this is why he has committed himself to the education of medical students, trainees and fellows.


  1. An ideal synthetic spacer for medial opening wedge high tibial osteotomy (MOWHTO) has not yet been developed. The authors have developed a new β-tricalcium phosphate (β-TCP) spacer with 60% porosity (N-CP60) b...

    Authors: Jun Yamaguchi, Eiji Kondo, Kazunori Yasuda, Jun Onodera, Koji Yabuuchi, Takuma Kaibara, Kimiaki Takami, Norimasa Iwasaki and Tomonori Yagi
    Citation: BMC Musculoskeletal Disorders 2024 25:441
  2. The shortcomings of plaster in water resistance, air permeability, skin comfort, fixed stability and weight of wearing are still to be solved. 3D printed cast can overcome the above shortcomings. At present, t...

    Authors: Ya-Ping Xiao, Hai-Jia Xu, Wen Liao and Zhang-Hua Li
    Citation: BMC Musculoskeletal Disorders 2024 25:104
  3. Alamandine is a newly characterized peptide of renin angiotensin system. Our study aims to investigate the osteo-preservative effects of alamandine, explore underlying mechanism and bring a potential preventiv...

    Authors: Wanxin Luo, Chen Yao, Jie Sun, Bo Zhang, Hao Chen, Jin Miao and Yafeng Zhang
    Citation: BMC Musculoskeletal Disorders 2024 25:45
  4. Gait retraining is a common therapeutic intervention that can alter gait characteristics to reduce knee loading in knee osteoarthritis populations. It can be enhanced when combined with biofeedback that provid...

    Authors: Yi Wan, Polly McGuigan, James Bilzon and Logan Wade
    Citation: BMC Musculoskeletal Disorders 2023 24:984
  5. Rodent models are commonly employed to validate preclinical disease models through the evaluation of postoperative behavior and allodynia. Our study investigates the dynamic interplay between pain and function...

    Authors: Yingfang Fan, Charlotte P. Leape, Shannon Hugard, Madeline McCanne, Andrew Thomson, Gregory R. Wojtkiewicz, Michael J. Weaver, Jamie E. Collins, Mark Randolph and Ebru Oral
    Citation: BMC Musculoskeletal Disorders 2023 24:854
  6. Tension band wiring (TBW) is a common surgical intervention for olecranon fractures. However, high rate of complications such as loss of reduction, skin irritation, and migration of the K-wires were reported u...

    Authors: Nuo Yin, Mingmang Pan, Chenglei Li, Li Du and Liang Ding
    Citation: BMC Musculoskeletal Disorders 2023 24:603
  7. Osteoarthritis, a common degenerative osteochondral disease, has a close relationship between its mechanism of occurrence and oxidative stress. However, there are relatively few relevant studies in this field,...

    Authors: Jin-Yu Gu, Fei Han, Si-Yu Chen and Qing Zhang
    Citation: BMC Musculoskeletal Disorders 2023 24:411
  8. To compare antibiotic-impregnated bone cement coverage (bone cement surface technique; BCS-T) versus vacuum sealing drainage (VSD) for tibial fracture with infected bone and soft tissue defect.

    Authors: Yanlong Zhang, Shuwei Tian, Meiyu Liu, Wenfang Zhai, Yujie Zhou and Aqin Peng
    Citation: BMC Musculoskeletal Disorders 2023 24:401
  9. This study aimed to compare the clinical outcomes of silicon ring tourniquets and conventional pneumatic tourniquets in total knee arthroplasty (TKA). The study compared the operation time, total bleeding amou...

    Authors: Tae sung Lee, Kwan Kyu Park, Byung Woo Cho, Woo-Suk Lee and Hyuck Min Kwon
    Citation: BMC Musculoskeletal Disorders 2023 24:363
  10. Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in severe functional deficits that have defied clinical repair strategies. In this manuscript we pair th...

    Authors: Kevin Roberts, John Taehwan Kim, Tai Huynh, Jacob Schluns, Grady Dunlap, Jamie Hestekin and Jeffrey C Wolchok
    Citation: BMC Musculoskeletal Disorders 2023 24:321
  11. Previous studies have shown that patients with hypercholesterolemia experience elevated levels of oxidized LDL (oxLDL), a molecule which triggers inflammation and collagenase activity. In this study we discove...

    Authors: Rouhollah Mousavizadeh, Charlie M. Waugh, Erin DeBruin, Robert G. McCormack, Vincent Duronio and Alex Scott
    Citation: BMC Musculoskeletal Disorders 2023 24:197
  12. The purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine ...

    Authors: Ruiting Zhu, Yirou Niu, Wei Zhou, Saikun Wang, Jing Mao, Yingze Guo, Yangyang Lei, Xuance Xiong, Yingzhi Li and Lirong Guo
    Citation: BMC Musculoskeletal Disorders 2023 24:124
  13. In the literature, factors associated with postoperative venous thromboembolisms (VTEs) after anterior cruciate ligament reconstruction (ACLR) are limited. This study aimed to investigate the incidence of veno...

    Authors: Yusuke Hashimoto, Eriko Komiya, Kazuya Nishino, Yohei Nishida, Atsushi Masuda and Hiroaki Nakamura
    Citation: BMC Musculoskeletal Disorders 2023 24:95
  14. The digital artery-based V–Y advancement flap is a widely used flap for soft tissue coverage in the treatment of flexion contracture of the proximal interphalangeal (PIP) joint. A standard method for the flap ...

    Authors: Po-Han Su, Cheng-En Hsu, Tsung-Yu Ho, Bor-Han Wei, Wei-Chih Wang and Yung-Cheng Chiu
    Citation: BMC Musculoskeletal Disorders 2023 24:33
  15. To determine the volume and applicability of local autogenous morselized bone (LAMB) harvested and used during posterior-transforaminal lumbar interbody fusion (P-TLIF) in the lower lumbar spine.

    Authors: Jin Yang, Yong Yang, Gaoju Wang, Shuang Xu, Guangzhou Li, Shuai Zhang, Chaohua Yang, Song Wang and Qing Wang
    Citation: BMC Musculoskeletal Disorders 2023 24:12
  16. To investigate the relationships between monosodium urate (MSU) crystals -induced neutrophil extracellular traps (NETs) and bone erosion in gout.

    Authors: Ertao Jia, Zhiling Li, Hongling Geng, Haiqiong Zhu, Yadong Wang, Feng Lin, Yubao Jiang and Jianyong Zhang
    Citation: BMC Musculoskeletal Disorders 2022 23:1128
  17. The purpose of this study was to investigate whether the addition of computed tomography (CT) to magnetic resonance imaging (MRI) improves the accuracy of classifying osteoporotic vertebral body fractures (OVBF).

    Authors: Ulrich J. Spiegl, Lars Behr, Georg Osterhoff, Gunnar Rupprecht, Max J. Scheyerer and Sebastian Katscher
    Citation: BMC Musculoskeletal Disorders 2022 23:1086
  18. To compare proprioception recovery after anterior cruciate ligament reconstruction (ACLR) with a hamstring tendon autograft versus the artificial Ligament Advanced Reinforcement System (LARS).

    Authors: Changli Xu, Tianze Liu, Miao Wang, Chang Liu, Bo Li, Qiujian Lian, Tongjiang Chen, Fengmei Chen, Suchi Qiao and Zhiwei Wang
    Citation: BMC Musculoskeletal Disorders 2022 23:1056
  19. Internal fixation of complex proximal humeral fractures (PHF) with osteoporosis is associated with a high incidence of complications. This study introduces the technique and clinical results of a novel intrame...

    Authors: Xuedong Bai, Zhengguo Zhu, Zuhao Chang, Lijun Sun, Peifu Tang and Hua Chen
    Citation: BMC Musculoskeletal Disorders 2022 23:1033
  20. People with hip osteoarthritis are typically offered a combination of education and exercise to address muscle atrophy and weakness. Limited evidence exists to assess the efficacy of exercise programs on muscl...

    Authors: Zachary P. J. Rostron, Anita Zacharias, Adam I. Semciw, Michael Kingsley, Tania Pizzari, Stephanie J. Woodley and Rodney Green
    Citation: BMC Musculoskeletal Disorders 2022 23:944
  21. Metabolic factors have been shown to be associated to severe radiographic knee osteoarthritis (RKOA). However, more knowledge is needed in early clinical knee osteoarthritis (KOA). The aim was to study associa...

    Authors: Maria Andersson, E Haglund, K Aili, A Bremander and S Bergman
    Citation: BMC Musculoskeletal Disorders 2022 23:938
  22. Antibiotic-loaded bone cement beads and spacers have been widely used for orthopaedic infection. Poor antibiotic elution is not capable of eradicating microbial pathogens and could lead to treatment failure. T...

    Authors: Tzu-Hao Tseng, Chih-Hao Chang, Chien-Lin Chen, Hongsen Chiang, Hao-Ying Hsieh, Jyh-Horng Wang and Tai-Horng Young
    Citation: BMC Musculoskeletal Disorders 2022 23:916
  23. Anterior cruciate ligament (ACL) rupture in humans is a common condition associated with knee pain, joint instability, and secondary osteoarthritis (OA). Surgical treatment with an intraarticular graft provide...

    Authors: Emily E. Binversie, Brian E. Walczak, Stephanie G. Cone, Lauren A. Baker, Tamara A. Scerpella and Peter Muir
    Citation: BMC Musculoskeletal Disorders 2022 23:116
  24. Knowledge regarding the biomechanics of the meniscus has grown exponentially throughout the last four decades. Numerous studies have helped develop this knowledge, but these studies have varied widely in their...

    Authors: Amin Mohamadi, Kaveh Momenzadeh, Aidin Masoudi, Kempland C. Walley, Kenny Ierardi, Arun Ramappa, Joseph P. DeAngelis and Ara Nazarian
    Citation: BMC Musculoskeletal Disorders 2021 22:625