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Translational Oncology

Global cancer occurrence has increased from 12.7 million new cases in 2008 to 14.1 million in 2012, and it is expected that the incidence will rise by around 70% over the next two decades. A comprehensive understanding of the pathophysiological processes underlying cancer development is of utmost importance for the development of detection techniques, diagnostic and prognostic markers, new therapies, risk assessment tools, and cancer prevention strategies.

Characterizing the molecular basis of cancer is a rapidly progressing area of research, with many laboratory discoveries translating into important advances that impact patient care. Our new cross-journal article collection on Translational Oncology aims to showcase the results of novel research findings that bridge the gap between basic science and cancer medicine.

The journals included in this collection are BMC Medicine, BMC Cancer, Cancers of the Head and Neck, Clinical Sarcoma Research and Journal of Experimental and Clinical Cancer Research. We are seeking submissions of research articles that provide important developments in cancer research. Preclinical studies should provide a significant advance in knowledge, and have clear potential for strong clinical impact. This collection will also include invited reviews, debates and commentaries. If you have any original research you would like us to consider for inclusion our Translational Oncology collection, please submit directly to your journal of choice, and state within your cover letter that you want the submission to be considered for this Translational Oncology article collection.

Guest Edited by Prof Tommaso Dragani (Fondazione IRCCS Istituto Nazionale dei Tumori, Italy), the series is now accepting submissions of research articles that provide important developments in cancer research. 

Please choose from the following list of journals to submit your article to:

  1. Research article

    ING3 promotes prostate cancer growth by activating the androgen receptor

    The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target ...

    Arash Nabbi, Urszula L. McClurg, Subhash Thalappilly, Amal Almami, Mahsa Mobahat, Tarek A. Bismar, Olivier Binda and Karl T. Riabowol

    BMC Medicine 2017 15:103

    Published on: 16 May 2017

  2. Research article

    Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

    Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 al...

    Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo and Kirsi J. Granberg

    BMC Cancer 2017 17:310

    Published on: 3 May 2017

  3. Research article

    S100β as a serum marker in endocrine resistant breast cancer

    Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired resistance. Here the potential of S100β as a biomarker and ...

    Sara Charmsaz, Éamon Hughes, Fiona T. Bane, Paul Tibbitts, Marie McIlroy, Christopher Byrne, Sinéad Cocchiglia, Jean McBryan, Bryan T. Hennessy, Róisín M. Dwyer, Michael J. Kerin, Arnold D. Hill and Leonie S. Young

    BMC Medicine 2017 15:79

    Published on: 12 April 2017

  4. Review

    Emerging concepts in liquid biopsies

    Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tum...

    Samantha Perakis and Michael R. Speicher

    BMC Medicine 2017 15:75

    Published on: 6 April 2017

  5. Research article

    Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

    Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study we...

    S. Battini, F. Faitot, A. Imperiale, A. E. Cicek, C. Heimburger, G. Averous, P. Bachellier and I. J. Namer

    BMC Medicine 2017 15:56

    Published on: 16 March 2017

  6. Review

    Molecular chess? Hallmarks of anti-cancer drug resistance

    The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is inevitable for many cancer patients, despite many impro...

    Ian A. Cree and Peter Charlton

    BMC Cancer 2017 17:10

    Published on: 5 January 2017

  7. Research

    Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer

    Release of exosomes have been shown to play critical roles in drug resistance by delivering cargo. Targeting the transfer of exosomes from resistant cells to sensitive cells may be an approach to overcome some...

    Xiaohong Wang, Chengfeng Xu, Yitong Hua, Leitao Sun, Kai Cheng, Zhongming Jia, Yong Han, Jianli Dong, Yuzhen Cui and Zhenlin Yang

    Journal of Experimental & Clinical Cancer Research 2016 35:186

    Published on: 1 December 2016

  8. Research article

    Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma

    Molecular intratumour heterogeneity (ITH) is common in clear cell renal carcinomas (ccRCCs). However, it remains unknown whether this is mirrored by heterogeneity of drug responses between metastases in the sa...

    Shanthini M. Crusz, Yen Zhi Tang, Shah-Jalal Sarker, Warner Prevoo, Irfan Kiyani, Luis Beltran, John Peters, Anju Sahdev, Axel Bex, Thomas Powles and Marco Gerlinger

    BMC Medicine 2016 14:185

    Published on: 14 November 2016

  9. Research article

    Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

    The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an ...

    Christine Jungk, Andreas Mock, Janina Exner, Christoph Geisenberger, Rolf Warta, David Capper, Amir Abdollahi, Sara Friauf, Bernd Lahrmann, Niels Grabe, Philipp Beckhove, Andreas von Deimling, Andreas Unterberg and Christel Herold-Mende

    BMC Medicine 2016 14:170

    Published on: 26 October 2016

  10. Research article

    Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set

    While clinical outcomes following immunotherapy have shown an association with tumor mutation load using whole exome sequencing (WES), its clinical applicability is currently limited by cost and bioinformatics...

    Jason Roszik, Lauren E. Haydu, Kenneth R. Hess, Junna Oba, Aron Y. Joon, Alan E. Siroy, Tatiana V. Karpinets, Francesco C. Stingo, Veera Baladandayuthapani, Michael T. Tetzlaff, Jennifer A. Wargo, Ken Chen, Marie-Andrée Forget, Cara L. Haymaker, Jie Qing Chen, Funda Meric-Bernstam…

    BMC Medicine 2016 14:168

    Published on: 25 October 2016

  11. Research article

    Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells

    High-grade non-muscle invasive bladder cancer (NMIBC) has a high risk of recurrence and progression to muscle-invasive forms, which seems to be largely related to the presence of tumorigenic stem-like cell pop...

    Margarida Ferreira-Teixeira, Daniela Paiva-Oliveira, Belmiro Parada, Vera Alves, Vitor Sousa, Obinna Chijioke, Christian Münz, Flávio Reis, Paulo Rodrigues-Santos and Célia Gomes

    BMC Medicine 2016 14:163

    Published on: 21 October 2016

  12. Research article

    Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening

    Non-invasive prenatal testing (NIPT) identifies fetal aneuploidy by sequencing cell-free DNA in the maternal plasma. Pre-symptomatic maternal malignancies have been incidentally detected during NIPT based on a...

    Paul A. Cohen, Nicola Flowers, Stephen Tong, Natalie Hannan, Mark D. Pertile and Lisa Hui

    BMC Medicine 2016 14:126

    Published on: 24 August 2016

  13. Forum

    Major milestones in translational oncology

    Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. Today, translational research in oncology benefits from an abundance of knowledge resulting from geno...

    Tommaso A. Dragani, Antoni Castells, Vathany Kulasingam, Eleftherios P. Diamandis, Helena Earl, Wade T. Iams, Christine M. Lovly, J. P. Michiel Sedelaar and Jack A. Schalken

    BMC Medicine 2016 14:110

    Published on: 28 July 2016

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