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The platelet derived non-coding RNAs and thrombosis: from bench to bed


Tong Yin, MD, PhD, Institute of Geriatrics, National Clinical Research Center of Geriatric Diseases, General Hospital of Chinese People's Liberation Army, Beijing, China

Submission Status: Closed

This collection is no longer accepting submissions.

Thrombosis Journal is calling for submissions to our collection on The platelet derived non-coding RNAs and thrombosis: from bench to bed. Platelets play a critical role in the development of thrombosis. Non-coding RNAs including microRNAs, circRNAs, lincRNAs, and YRNAs are enriched in platelet. Platelet non-coding RNAs have been established in the mechanisms of platelet formation and activation, as well as correlated to platelet function and thereby generated interest as biomarkers of thrombotic diseases. 

Image credit: Tong Yin 

  1. Platelet is enriched with Circular RNAs (circRNAs), with circFAM13B rank among the 10 most abundant circRNAs in platelets. The aim of the present study was to evaluate the predictive value of platelet-derived ...

    Authors: Yuting Zou, Yuyan Wang, Yanzhu Yao, Yangxun Wu, Chao Lv and Tong Yin
    Citation: Thrombosis Journal 2024 22:53
  2. In this report, we report a case of a middle-aged male, admitted to the ICU with cerebral hemorrhage resulting from a severe high-altitude fall. The patient encountered significant challenges in oxygenation in...

    Authors: Lijie Wang, Chengyong Ma, Luping Wang, Qianrong Ding, Hao Yang, Bo Wang and Qin Wu
    Citation: Thrombosis Journal 2024 22:36

About the collection

Thrombosis Journal is calling for submissions to our collection on The platelet derived non-coding RNAs and thrombosis: from bench to bed. Platelet is enriched with non-coding RNAs, including microRNAs, circular RNAs, long non-coding RNAs, YRNAs and exogenous plant non-coding RNAs. Non-coding RNAs of platelets have been explored in the mechanisms of megakaryocytic differentiation, platelet formation, vascular homeostasis, and inflammation. An accumulating body of evidence suggests that quantitative differences in the relative abundance of non-coding RNAs contribute to susceptibility to, and prog­nosis of, human thrombotic diseases. However, important questions upon non-coding RNAs of platelet remain unanswered, including the specific function in acute and chronic thrombotic diseases, the interaction with the signaling pathway of platelet activation, the role in transcription and translation, and the physiological relevance of transferring into and out of platelets. Moreover, it remains to be seen whether platelet reactivity signatures based on non-coding RNAs measurements can address the clinical need or improve risk management of thrombotic complications. Therefore, studies on the Non-coding RNAs of platelet are greatly needed for the enlightening the potential mechanisms behind thrombosis and the practical value for clinical application.

Suggestions for possible topics could include:

• Non-coding RNAs as regulators for the signaling pathways of platelet activation;

• Non-coding RNAs in platelet as mediators of cross-talk with other cell types;

• Non-coding RNAs in platelet as potential biomarkers for thrombotic diseases; 

• Non-coding RNAs in platelet as therapeutic target for thrombotic diseases.

Submission Guidelines

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This Collection welcomes submission of Research Articles, Data Notes, Case Reports, Study Protocols, and Database Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "The platelet derived non-coding RNAs and thrombosis: from bench to bed" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editor have no competing interests with the submissions which she will handle through the peer review process. The peer review of any submissions for which the Editor has competing interests is handled by another Editorial Board Member who has no competing interests.