Edited by Professor Shigeki Kushimoto
This thematic series was published in Journal of Intensive Care
Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. During the last 10 years, there has been a dramatic evolution in our understanding of trauma-induced coagulopathy. For example, trauma itself and traumatic shock-induced endogenous coagulopathy are both referred to as acute traumatic coagulopathy (ATC) and multifactorial trauma-associated coagulation impairment. Alongside these understandings, a widespread paradigm shift in the resuscitation of critically injured patients has been observed. Understanding the pathophysiology of trauma-induced coagulopathy and novel therapeutic strategies are therefore vitally important issues for the management of patients with severe trauma.
Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype
In severe trauma patients, coagulopathy is frequently observed in the acute phase of trauma. Trauma-induced coagulopathy is coagulopathy caused by the trauma itself. The pathophysiology of trauma-induced coagu...