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TGF-ß signaling and biology

TGF-β and its related factors regulate a broad range of cellular functions, including proliferation, differentiation, apoptosis, migration, and adhesion. These factors are also very important in the pathogenesis of cancer and many other diseases. Although much has been known about the TGF-β signaling pathway since the discovery of Smads 15 years ago, remarkable progress has been made in revealing details of different regulatory mechanisms that afford a full range of control of the biological functions of these factors in the TGF-β family. Specific physiological and pathological roles of TGF-β/Smad in different cellular context also start to emerge. This collection of review articles provides a broad, albeit not all-inclusive, overview of the latest breakthroughs and developments in TGF-β signaling and biology.

Dr Ying Zhang

  1. Review

    Partners in crime: the TGFβ and MAPK pathways in cancer progression

    The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. In the absence of cellular transformation, these pathways operate...

    Douglas A Chapnick, Lisa Warner, Jennifer Bernet, Timsi Rao and Xuedong Liu

    Cell & Bioscience 2011 1:42

    Published on: 28 December 2011

  2. Review

    Unraveling the biological functions of Smad7 with mouse models

    Smad7 is a key negative regulator of the transforming growth factor β (TGF-β) signaling and plays an important role in modulating a large array of biological processes. The physiological actions of Smad7 have ...

    Lu Zhu, Susie Chen and Yan Chen

    Cell & Bioscience 2011 1:44

    Published on: 28 December 2011

  3. Review

    Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad

    Smad proteins are the intracellular mediators of transforming growth factor β (TGF-β) signaling. Smads function as transcription factors and their activities require carboxyl-terminal phosphorylation by TGF-β ...

    Xiaochu Chen and Lan Xu

    Cell & Bioscience 2011 1:40

    Published on: 28 December 2011

  4. Review

    Non-degradative ubiquitination in Smad-dependent TGF-β signaling

    Transforming growth factor-β (TGF-β) signaling is tightly regulated at the level of post-translational modification to transmit quantitative difference in ligand concentration into proportional transcriptional...

    Liu-Ya Tang and Ying E Zhang

    Cell & Bioscience 2011 1:43

    Published on: 28 December 2011

  5. Review

    Roles of TGFβ signaling Smads in squamous cell carcinoma

    Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. Smad1/5/8 mainly mediate bone morphogenetic proteins (BMP) pat...

    Gangwen Han and Xiao-Jing Wang

    Cell & Bioscience 2011 1:41

    Published on: 28 December 2011