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Tissue engineering & scar management

Edited by: Naiem S Moiemen, Cecilia Li-Tsang

Hypertrophic scar has always been the top priority of post burn intervention. A wide variety of modalities have been reported and evaluated on their clinical efficacy, such as surgical removal, splinting, postoperative ambulation, conditioning, scar massage, Laser treatment, radiation therapy, intralesional injections of medications and use of compression garments, etc. However, different methods were recommended by expert panels of different regions. Nowadays, tissue engineering, an innovative technology, has been demonstrated to be effective in enhancing early wound healing. Also, it is studied extensively and considered as a very promising preventive measure against hypertrophic scarring.

This thematic series covers several key aspects of scar medicine, namely, the understanding of scar formation, objective methods of scar measurements, as well as developments in prevention and treatment of hypertrophic scar, with a special focus on application of tissue-engineering in scar management.

This series was published in Burns & Trauma. 

  1. Joint contracture is the major clinical complication in burn patients, especially, the severe burn patients. This study aimed to investigate the number and severity of joint contractures in patients with burns...

    Authors: Jianglin Tan, Jian Chen, Junyi Zhou, Huapei Song, Huan Deng, Ming Ao, Gaoxing Luo and Jun Wu
    Citation: Burns & Trauma 2019 7:17
    Content type: Research article Published on:

  4. Vacuum massage is a non-invasive mechanical massage technique performed with a mechanical device that lifts the skin by means of suction, creates a skin fold and mobilises that skin fold. In the late 1970s, th...

    Authors: Peter Moortgat, Mieke Anthonissen, Jill Meirte, Ulrike Van Daele and Koen Maertens
    Citation: Burns & Trauma 2016 4:34
    Content type: Review Published on:

  5. Keloids are an extreme form of abnormal scarring that result from a pathological fibroproliferative wound healing process. The molecular mechanisms driving keloid pathology remain incompletely understood, hind...

    Authors: Jennifer M. Hahn, Kevin L. McFarland, Kelly A. Combs and Dorothy M. Supp
    Citation: Burns & Trauma 2016 4:30
    Content type: Research article Published on:

  6. Vacuum massage is a non-invasive mechanical massage technique invented to treat burns and scars. To date, no effects of vacuum massage on thickness and density of human scar tissue have been reported. The proc...

    Authors: Jill Meirte, Peter Moortgat, Mieke Anthonissen, Koen Maertens, Cynthia Lafaire, Lieve De Cuyper, Guy Hubens and Ulrike Van Daele
    Citation: Burns & Trauma 2016 4:27
    Content type: Research article Published on:

  9. Problematic scarring remains a challenging aspect to address in the treatment of burns and can significantly affect the quality of life of the burn survivor. At present, there are few treatments available in t...

    Authors: Kwang Chear Lee, Janine Dretzke, Liam Grover, Ann Logan and Naiem Moiemen
    Citation: Burns & Trauma 2016 4:14
    Content type: Research article Published on:

  10. Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for c...

    Authors: Alvin Wen Choong Chua, Yik Cheong Khoo, Bien Keem Tan, Kok Chai Tan, Chee Liam Foo and Si Jack Chong
    Citation: Burns & Trauma 2016 4:3
    Content type: Review Published on:

  11. Hypertrophic scars (HTS) are caused by dermal injuries such as trauma and burns to the deep dermis, which are red, raised, itchy and painful. They can cause cosmetic disfigurement or contractures if craniofaci...

    Authors: Zhensen Zhu, Jie Ding and Edward E. Tredget
    Citation: Burns & Trauma 2016 4:2
    Content type: Review Published on:

  12. Nowadays, most patients with severe burns will survive their injury. This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned. Consequently, more and more pa...

    Authors: PPM van Zuijlen, KLM Gardien, MEH Jaspers, EJ Bos, DC Baas, AJM van Trier and E Middelkoop
    Citation: Burns & Trauma 2015 3:18
    Content type: Review Published on:

  13. A hypertrophic scar is a unique fibrotic disease that only exists in humans. Despite advances in burn care and rehabilitation, as well as progress in the management during these decades, the hypertrophic scar ...

    Authors: Jianglin Tan, Weifeng He, Gaoxing Luo and Jun Wu
    Citation: Burns & Trauma 2015 3:13
    Content type: Research article Published on:

  14. The aim of this review was to explore the existing body of literature focusing on the intralesional treatments of keloids and hypertrophic scars.

    Authors: Aurelia Trisliana Perdanasari, Matteo Torresetti, Luca Grassetti, Fabio Nicoli, Yi Xin Zhang, Talal Dashti, Giovanni Di Benedetto and Davide Lazzeri
    Citation: Burns & Trauma 2015 3:14
    Content type: Research article Published on: