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Tissue engineering & scar management

Edited by: Naiem S Moiemen, Cecilia Li-Tsang

Hypertrophic scar has always been the top priority of post burn intervention. A wide variety of modalities have been reported and evaluated on their clinical efficacy, such as surgical removal, splinting, postoperative ambulation, conditioning, scar massage, Laser treatment, radiation therapy, intralesional injections of medications and use of compression garments, etc. However, different methods were recommended by expert panels of different regions. Nowadays, tissue engineering, an innovative technology, has been demonstrated to be effective in enhancing early wound healing. Also, it is studied extensively and considered as a very promising preventive measure against hypertrophic scarring.

This thematic series covers several key aspects of scar medicine, namely, the understanding of scar formation, objective methods of scar measurements, as well as developments in prevention and treatment of hypertrophic scar, with a special focus on application of tissue-engineering in scar management.

Collection published: 21 January 2016

  1. Review

    Biomaterials and tissue engineering for scar management in wound care

    Scars are a natural and unavoidable result from most wound repair procedures and the body’s physiological healing response. However, they scars can cause considerable functional impairment and emotional and so...

    Maedeh Rahimnejad, Soroosh Derakhshanfar and Wen Zhong

    Burns & Trauma 2017 5:4

    Published on: 21 January 2017

  2. Research article

    Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

    Keloids are an extreme form of abnormal scarring that result from a pathological fibroproliferative wound healing process. The molecular mechanisms driving keloid pathology remain incompletely understood, hind...

    Jennifer M. Hahn, Kevin L. McFarland, Kelly A. Combs and Dorothy M. Supp

    Burns & Trauma 2016 4:30

    Published on: 23 August 2016

  3. Research article

    Short-term effects of vacuum massage on epidermal and dermal thickness and density in burn scars: an experimental study

    Vacuum massage is a non-invasive mechanical massage technique invented to treat burns and scars. To date, no effects of vacuum massage on thickness and density of human scar tissue have been reported. The proc...

    Jill Meirte, Peter Moortgat, Mieke Anthonissen, Koen Maertens, Cynthia Lafaire, Lieve De Cuyper, Guy Hubens and Ulrike Van Daele

    Burns & Trauma 2016 4:27

    Published on: 8 July 2016

  4. Research article

    A systematic review of objective burn scar measurements

    Problematic scarring remains a challenging aspect to address in the treatment of burns and can significantly affect the quality of life of the burn survivor. At present, there are few treatments available in t...

    Kwang Chear Lee, Janine Dretzke, Liam Grover, Ann Logan and Naiem Moiemen

    Burns & Trauma 2016 4:14

    Published on: 27 April 2016

  5. Review

    The molecular basis of hypertrophic scars

    Hypertrophic scars (HTS) are caused by dermal injuries such as trauma and burns to the deep dermis, which are red, raised, itchy and painful. They can cause cosmetic disfigurement or contractures if craniofaci...

    Zhensen Zhu, Jie Ding and Edward E. Tredget

    Burns & Trauma 2016 4:2

    Published on: 21 January 2016

  6. Review

    Tissue engineering in burn scar reconstruction

    Nowadays, most patients with severe burns will survive their injury. This evolution is accompanied by the challenge to cover a large percentage of total body surface area burned. Consequently, more and more pa...

    PPM van Zuijlen, KLM Gardien, MEH Jaspers, EJ Bos, DC Baas, AJM van Trier and E Middelkoop

    Burns & Trauma 2015 3:18

    Published on: 30 September 2015