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Tissue Engineering

Guest Editor(s):

Hon Fai Chan: The Chinese University of Hong Kong, China
Kulwinder Kaur: Royal College of Surgeons in Ireland, Ireland
Subhadeep Roy: National Institute of Pharmaceutical Education and Research (NIPER), India

The Editors of BMC Biomedical Engineering and BMC Biotechnology welcomed submissions to our Cross-Journal Collection on Tissue Engineering. The collection aimed to cover advances in biomaterials, stem cells, growth and differentiation factors, and biomimetic environments which are creating unique opportunities to fabricate or improve organic tissue engineering.

Meet the Guest Editors

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Hon Fai Chan: The Chinese University of Hong Kong, China

Hon Fai Chan is an Assistant Professor at the Institute for Tissue Engineering and Regenerative Medicine and the School of Biomedical Sciences at The Chinese University of Hong Kong (CUHK). Prof. Chan’s research mainly focuses on advancing biofabrication approaches and biomaterial design for stem cell tissue engineering and regenerative medicine, as well as understanding how microenvironmental cues influence stem cell proliferation and differentiation.


Kulwinder Kaur: Royal College of Surgeons in Ireland, Ireland

Kulwinder Kaur is a research Fellow at Marie Skłodowska-Curie Actions (MSCA) in RCSI, Dublin. Dr. Kaur’s main area of research is the synthesis of NanoEngineered Injectable Hydrogels for osteoporotic vertebral bone fractures and additionally has extensive experience in bone regeneration, biomaterials science, materials science, and in vitro studies.

Subhadeep Roy: National Institute of Pharmaceutical Education and Research (NIPER), India

Subhadeep Roy is an assistant professor at NIPER (National Institute of Pharmaceutical Education and Research), in Kolkata (India), where he specializes in pharmacology and toxicology. Currently, he is developing in vitro disease platforms to use in regenerative medicine and the evaluation of pharmaceutical drugs. After finishing his doctorate, he worked as a research associate at the Penn State College of Medicine (United States) and the Regenerative Engineering Laboratory at the Indian Institute of Technology (Delhi, India).  His postdoctoral work has involved studying how to control immune reactions to biomaterials, as well as studies of decellularized matrix and bioengineered human cornea. He has also worked as a visiting senior research fellow at the ID3S (Implant, Device, Drug, Drug Delivery System), Translational Health Science and Technology Institute (Faridabad, India), in targeted drug delivery of anti-tubercular formulation and compartment trafficking in human pulmonary macrophages.

About the collection

The Editors of BMC Biomedical Engineering and BMC Biotechnology announce the launch and call for research articles on Tissue Engineering. 

Tissue engineering brings together multiple aspects of science, medicine and engineering. It starts from using cells as building blocks on scaffolds to large scale whole structures towards medicinal use. Scientific advances in biomaterials, stem cells, growth and differentiation factors, and biomimetic environments have created unique opportunities to fabricate or improve regenerative engineering.   Different laboratories use combinations of engineered extracellular matrices ("scaffolds"), cells, and biologically active molecules to mimic the in vivo conditions. Among the major challenges now facing tissue engineering is the need for more complex functionality, biomechanical stability, and vascularization in laboratory-grown tissues destined for transplantation. There are also very few stringent protocols to judge the immunogenicity of different implantable biomaterials and extracellular matrices. The role of circulating monocytes and resident macrophages after implantation is still not completely understood, which makes the outcome more unpredictable.  At this brink of breakthrough research, BMC Biotechnology and BMC Biomedical Engineering welcome submissions to their collection on Tissue engineering. The use of biomaterials in regenerative medicine for development of multiple lineages and specific organs will be covered. The special issue will consider different types of natural and synthetic biomaterial use for regenerative purposes. Innovative research on extracellular matrix and stem cells responsive biomaterials are welcome. Recent advancement and greater challenges in biomaterial mediated drug or small molecule delivery, additive manufacturing will be the major thrust here. 

The broad areas of research covered by this collection include: 

  • Advances in tissue culture including bio-reactors and bio-artificial organs.
  • Advances and developments in tissue assembly methods including techniques like 3D scaffolding and hydrogels 
  • Bioprinting, nanofibres and nanomaterials
  • stem-cell -use in regenerative medicine
  • Isolation and purification of primary cells towards application
  • Lab-grown organs and tissues
  • Biomaterials in drug or small molecule delivery, Additive Manufacturing
  • Extracellular matrix, decellularization 
  • Biodegradable nanomaterials including nano-polymers
  • Computational modeling in tissue engineering
  1. Antibiotic-containing carrier systems are one option that offers the advantage of releasing active ingredients over a longer period of time. In vitro sustained drug release from a carrier system consisting of ...

    Authors: Lucas Ritschl, Pia Schilling, Annette Wittmer, Annerose Serr, Hagen Schmal and Michael Seidenstuecker
    Citation: BMC Biotechnology 2024 24:38
  2. To establish a strategy for stem cell-related tissue regeneration therapy, human gingival mesenchymal stem cells (hGMSCs) were loaded with three-dimensional (3D) bioengineered Matrigel matrix scaffolds in high...

    Authors: Shukui Xu, Liru Zhao, Yinghui Li, Xiuge Gu, Ziyang Liu, Xing Han, Wenwen Li and Wensheng Ma
    Citation: BMC Biotechnology 2024 24:36
  3. β-TCP ceramics are versatile bone substitute materials and show many interactions with cells of the monocyte-macrophage-lineage. The possibility of monocytes entering microporous β-TCP ceramics has however not...

    Authors: Marco Waldmann, Marc Bohner, Long-Quan R. V. Le, Anna Baghnavi, Bianca Riedel and Michael Seidenstuecker
    Citation: BMC Biotechnology 2024 24:32
  4. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and it leads to irreversible inflammation in intra-articular joints. Current treatment approaches for RA include non-steroidal anti-infla...

    Authors: Dipesh Kumar Shah, Sumanta Ghosh, Namdev More, Mounika Choppadandi, Mukty Sinha, Sarath Babu Srivalliputtur, Ravichandiran Velayutham and Govinda Kapusetti
    Citation: BMC Biotechnology 2024 24:26
  5. Volumetric loss is one of the challenging issues in muscle tissue structure that causes functio laesa. Tissue engineering of muscle tissue using suitable hydrogels is an alternative to restoring the physiological...

    Authors: Atieh Rezaei Namjoo, Ayla Hassani, Hassan Amini, Fateme Nazaryabrbekoh, Sepideh Saghati, Mohammad Ali Ebrahimi Saadatlou, Ali Baradar Khoshfetrat, Nafiseh Didar Khosrowshahi and Reza Rahbarghazi
    Citation: BMC Biotechnology 2024 24:23
  6. Modern high-throughput technologies enable the processing of a large number of samples simultaneously, while also providing rapid and accurate procedures. In recent years, automated liquid handling workstation...

    Authors: Giovanni Annona, Assunta Liberti, Carla Pollastro, Antonietta Spagnuolo, Paolo Sordino and Pasquale De Luca
    Citation: BMC Biotechnology 2024 24:4
  7. In tissue engineering (TE) and regenerative medicine, the accessibility of engineered scaffolds that modulate inflammatory states is extremely necessary. The aim of the current work was to assess the efficacy ...

    Authors: Akram Firouzi Amandi, Seyed Abbas Shahrtash, Shaylan Kalavi, Afshin Moliani, Hanieh Mousazadeh, Mehdi Rezai Seghin Sara and Mehdi Dadashpour
    Citation: BMC Biotechnology 2023 23:55
  8. The major safety concern of the clinical application of wild type FGF19 (FGF19WT) emerges given that its extended treatment causes hepatocellular carcinoma. Therefore, we previously generated a safer FGF19 varian...

    Authors: Lu Shi, Tiantian Zhao, Lei Huang, Xiaomin Pan, Tianzhen Wu, Xin Feng, Taoli Chen, Jiamin Wu and Jianlou Niu
    Citation: BMC Biotechnology 2023 23:43
  9. Cartilage defects are common sports injuries without significant treatment. Articular cartilage with inferior regenerative potential resulted in the poor formation of hyaline cartilage in defects. Acellular ma...

    Authors: Huiming Jiang, Jun Lu, Jiawei Li, Zizheng Liu, Fufei Chen, Rui Wu, Xingquan Xu, Yuan Liu, Yiqiu Jiang and Dongquan Shi
    Citation: BMC Biotechnology 2023 23:38
  10. Gelatin methacrylate-based hydrogels (GelMA) were widely used in tissue engineering and regenerative medicine. However, to manipulate their various chemical and physical properties and create high-efficiency h...

    Authors: Nahideh Asadi, Hadi Sadeghzadeh, Azizeh Rahmani Del Bakhshayesh, Amir Nezami Asl, Mehdi Dadashpour, Negar Karimi Hajishoreh, Sharif Kaamyabi and Abolfazl Akbarzadeh
    Citation: BMC Biotechnology 2023 23:21
  11. To investigate the effect of low-intensity pulsed ultrasound (LIPUS) combined with lipid microbubbles on the proliferation and bone regeneration of bone marrow mesenchymal stem cells (BMSCs) in poly (lactic-gl...

    Authors: Lin Jin, Jiali Shan, Yanhong Hao, Yingchun Wang and Liping Liu
    Citation: BMC Biotechnology 2023 23:13
  12. Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intesti...

    Authors: Prem Kumar Govindappa, Mosammat Begom, Yash Gupta, John C. Elfar, Manmeet Rawat and Walaa Elfar
    Citation: BMC Biotechnology 2023 23:12